ÇOKLU DOYMAMIŞ YAĞ ASİTLERİNİN ANTİ-TROİT ETKİSİ VE BİTKİLER

Öz

Çoklu doymamış yağ asitleri (PUFA), troit uyarımını baskılar. PUFA’lar troit hormonu
seviyelerini baskılayarak şişmanlığa neden olur. Baskılanan troid metabolizmayı yavaşlatır.
Aşırı PUFA diyeti kilo alımına neden olur. Böylesi düşük kalori alımı da kalıcı olan kilo
alımına yol açabilir. Bu sonuç azalmış troid aktivitesi ile uyuşmaktadır.

Anahtar Kelimeler

• Çoklu doymamış yağ asitleri,bitki,troit.

ANTI-THROID EFFECTS OF PUFAS (POLYUNSATURATED FATS) AND HERBS

Abstract

Polyunsaturated fats (PUFA) suppress thyroid signaling. PUFAs suppress thyroid hormone levels and cause weight gain. Inhibiting the thyroid slows the metabolism. The highPUFA diet promoted weight gain: it caused excess weight to be retained at a l ower calorie intake. This is consistent with reduced thyroid activity.

Keywords

• Polyunsaturated fats,herb,throid.

References

1. BABAYAN, V. K. "Medium chain triglycerides and structured lipids," Lipids 22, 417-20. 1987.
2. BROCKELHURST, W. E. Pharmacological mediators of hypersensitivity reactions, in Clinical Aspects of Immunology (P. G. H. Gell and R. R. A. Coombs, editors) Blackwell Scientific, P. A. Davis Co., Phil. p. 360. 1963.
3. BRODA, B. and GALTON, L. Hypothyroidism: The Unsuspected Illness, T. Y. Crowell, New York. 1976.
4. DANFORTH, E., and BURGER, A. The role of thyroid hormones in the control of energy expenditure. Clin Endocrinol Metab. 1984 Nov;13(3): 581-95. 1984.
5. DESHPANDE, N., HULBERT, A.J. Dietary omega 6 fatty acids and the effects of hyperthyroidism in mice. J Endocrinol. 144(3):431-9. 1995.
6. DUPLUS, E. and FOREST, C. Is there a single mechanism for fatty acid regulation of gene transcription? Biochemical Pharmacology, 64, 893–901. 2002.
7. JIA, G., TOHYAMA, C., SONE, H. DNA damage triggers imbalance of proliferation and apoptosis during development of preneoplastic foci in liver of long-evans cinnamon rats. Int J Oncol. 21: 755. 2002.
8. LEV, B.J.M. and GRAND, C.G. "Enhancement of mammary fibroadenoma in female rat by a high fat diet," Cancer Res. 16, 137. 1956.

9. Malik, R., Hodgson, H. The relationship between thyroid gland and the liver. Q J Med. 95:559. 2002.
10. MONTIEL, O.J.F., PASCUAL, A., ARANDA, A. "Modulation of thyroid hormone nuclear receptors by short-chain fatty acids in glial C6 cells. Role of histone acetylation," J Biol Chem. 25;261(30):13997-4004. 1986.
11. MURADOĞLU F.H., OĞUZ I., YILDIZ K., YILMAZ H. Some chemical composition of walnut (Juglans regia L.) selections from Eastern Turkey. Afr. J. Agric. Res., 5: 2379-2385. 2010.
12. TANNENBAUM, A., and SİLVERSTONE, H. "Effects of varying proportion of protein in the diet," Cancer Res. 9, 162. 1949.
13. PEREIRA J.A., OLIVEIRA I., SOUSA A., FERREIRA ICFR., BENTO A.,
14. ESTEVINHO L. Bioactive properties and chemical composition of six walnut (Juglans regia L.) cultivars. Food Chem. Toxicol. 46: 2103–2111. 2008.
15. POIRIER, M.C. Chemical induced DNA damage and human cancer risk. Nature cancer review. 4: 630. 2004.
16. PRASAD, K. N. "Minireview: butyric aicd," Life Science 27, 1351-8. 1980.
17. RADWAN, S.S. Sources of C20-polyunsaturated fatty acids for biotechnological use. Applied Microbiology And Biotechnology. Volume 35, Number 4, 421-430. 1991.
18. ROUSSEAU, G. G. "Control of gene expression by glucocorticoid hormones," Biochem. J. 224, 1-12. 1984.
19. SAVAGE G.P. Chemical composition of walnuts (Juglans regia L.) grown in New Zealand. Plant Foods Hum. Nutr., 56: 75-82. 2001.
20. SINCLAIR, H. History of EFA & their prostanoids: some personal reminiscences. Progress in Lipid Research, 25: 667-72. 1986.
21. SOUZA, L.L., NUNES, M.O., PAULA, G.S., CORDEİRO, A., PENHA-PINTO, V., NETO, J.F., OLIVEIRA, K.J., DO CARMO, M.G., PAZOS-MOURA, C.C. Effects of dietary fish oil on thyroid hormone signaling in the liver. J Nutrition Biochemical. 21(10): 935-40. 2010.
22. VAN DER KLIS F.R., SCHMIDT E.D.,VAN BEEREN H.C., WIERSINGA W.M. Competitive inhibition of T3 binding to alpha 1 and beta 1 thyroid hormone receptors by fatty acids.Biochem Biophys Res Commun. 179:1011– 1016. 1991.
23. WEBER, L.W., BOLL, M., STAMPFL, A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical Review Toxicol. 33:105. 2003.
24. WEISS, L. A., CONNOR, E.B. and MUHLEN, D.V. Ratio of n−6 to n−3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study1,2,3. American Society for Clinical Nutrition. Vol. 81 no. 4, 934-938. 2005.