CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA

Omer Faruk Karatas; Seyma Teber; Ahmet Yilmaz; Asli Baltacioglu; Selinay Merve Kilic; Emel Poyraz; Abdulmelik Aytatli; Sumeyye Ozturk; Ayse Varol

doi:10.23902/trkjnat.368829

TR EN

CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA

Abstract

Dil skuamöz hücreli karsinomu (DSHK) son 5 yılda artan insidans ve mortalite oranları ile birlikte diğer ağız içi kanserleri arasında en kötü huylu kanser tipi olarak bilinmektedir. DSHK hastalarının yaşam süreleri sınırlı olduğundan ve mevcut kemo-radyoterapi yaklaşımlarının başarılı olmamasından dolayı acilen yeni biyolojik belirteçlere ihtiyaç duyulmaktadır. Diğer solid (katı) tümörlerde olduğu gibi, DSHK’da da, tümörün başlaması, gelişmesi, yayılması, nüksetmesi ve kemo-radyoterapiye direnç göstermesi noktasında itici bir güç olarak kabul edilen “kanser kök hücreleri” (KKH) olarak tanımlanan küçük bir alt popülasyonu da kapsayan heterojen bir hücre popülasyonuna sahiptir. KKH’nin kanser oluşum sürecinde nasıl bir katkı yaptıklarının altında yatan moleküler mekanizmalar tamamen anlaşılamamış olmasına rağmen, bilim insanları ve klinik tedavi uzmanları DSHK da dâhil olmak üzere kansere karşı mücadelede bu hücreleri tedavi edici araçlar olarak kullanmayı amaçlamaktadır. Burada, DSHK’daki potansiyel kanser kök hücrelerinin belirteçlerine ışık tutmak için önemli bulguları ve en güncel literatürü gözden geçirdik ve derledik. Ayrıca, DSHK kanser başlangıcı, ilerlemesi, invazyonu ya da metastazı sırasında KKH biyo-belirteçlerinin olası fonksiyonları özetlenmiştir.

Keywords

Tongue squamous cell carcinoma,cancer stem cell,biomarker

CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA

Abstract

Tongue squamous cell carcinoma (TSCC) is known to be the most malignant cancer type amongst other oral cancers with increasing incidence and mortality rates in the past five years. Since the life expectancy for TSCC patients is limited and the current chemo-radiotherapy treatments are not curative, novel biomarkers are urgently needed. As many other solid tumors, TSCC has a heterogeneous cancer cell population, which includes a small subpopulation identified as cancer stem cells (CSCs) that are considered as the driving force for tumor initiation, development, spread, recurrence, and resistance to chemo-radiotherapy. Although the underlying molecular mechanisms of how CSCs are involved in the carcinogenesis are not completely understood, scientists and clinicians aim to utilize those cells as therapeutic tools in fight against different cancer types including TSCC. Here, we reviewed and summarized important findings and the most current literature to shed light on the potential of cancer stem cells markers in TSCC. Possible functions of CSCs biomarkers in TSCC pathogenesis during cancer initiation, progression, invasion or metastasis are also summarized.

Keywords

cancer stem cell,biomarker,Tongue squamous cell carcinoma

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Review

Authors

Omer Faruk Karatas ^*
Türkiye

Seyma Teber This is me

Ahmet Yilmaz This is me

Asli Baltacioglu This is me

Selinay Merve Kilic This is me

Emel Poyraz This is me

Abdulmelik Aytatli This is me

Sumeyye Ozturk This is me

Ayse Varol This is me

Publication Date

October 15, 2018

Submission Date

December 19, 2017

Acceptance Date

June 3, 2018

Published in Issue

Year 2018 Volume: 19 Number: 2

DOI

https://doi.org/10.23902/trkjnat.368829

IZ

https://izlik.org/JA49HU84TC

Cite

RIS / Bibtex

APA

Karatas, O. F., Teber, S., Yilmaz, A., Baltacioglu, A., Kilic, S. M., Poyraz, E., Aytatli, A., Ozturk, S., & Varol, A. (2018). CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA. Trakya University Journal of Natural Sciences, 19(2), 197-207. https://doi.org/10.23902/trkjnat.368829

AMA

1.Karatas OF, Teber S, Yilmaz A, et al. CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA. Trakya Univ J Nat Sci. 2018;19(2):197-207. doi:10.23902/trkjnat.368829

Chicago

Karatas, Omer Faruk, Seyma Teber, Ahmet Yilmaz, et al. 2018. “CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA”. Trakya University Journal of Natural Sciences 19 (2): 197-207. https://doi.org/10.23902/trkjnat.368829.

EndNote

Karatas OF, Teber S, Yilmaz A, Baltacioglu A, Kilic SM, Poyraz E, Aytatli A, Ozturk S, Varol A (October 1, 2018) CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA. Trakya University Journal of Natural Sciences 19 2 197–207.

IEEE

[1]O. F. Karatas et al., “CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA”, Trakya Univ J Nat Sci, vol. 19, no. 2, pp. 197–207, Oct. 2018, doi: 10.23902/trkjnat.368829.

ISNAD

Karatas, Omer Faruk - Teber, Seyma - Yilmaz, Ahmet - Baltacioglu, Asli - Kilic, Selinay Merve - Poyraz, Emel - Aytatli, Abdulmelik - Ozturk, Sumeyye - Varol, Ayse. “CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA”. Trakya University Journal of Natural Sciences 19/2 (October 1, 2018): 197-207. https://doi.org/10.23902/trkjnat.368829.

JAMA

1.Karatas OF, Teber S, Yilmaz A, Baltacioglu A, Kilic SM, Poyraz E, Aytatli A, Ozturk S, Varol A. CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA. Trakya Univ J Nat Sci. 2018;19:197–207.

MLA

Karatas, Omer Faruk, et al. “CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA”. Trakya University Journal of Natural Sciences, vol. 19, no. 2, Oct. 2018, pp. 197-0, doi:10.23902/trkjnat.368829.

Vancouver

1.Omer Faruk Karatas, Seyma Teber, Ahmet Yilmaz, Asli Baltacioglu, Selinay Merve Kilic, Emel Poyraz, Abdulmelik Aytatli, Sumeyye Ozturk, Ayse Varol. CURRENT CANCER STEM CELL BIOMARKERS IN TONGUE SQUAMOUS CELL CARCINOMA. Trakya Univ J Nat Sci. 2018 Oct. 1;19(2):197-20. doi:10.23902/trkjnat.368829