EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)

Hasan Hüseyin Doğan; Rüstem Duman

doi:10.23902/trkjnat.543382

Research Article

EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)

Year 2019, , 121 - 127, 15.10.2019

Hasan Hüseyin Doğan , Rüstem Duman

https://doi.org/10.23902/trkjnat.543382

Cited By: 1

Abstract

In order to find new and effective antiviral agents from
natural sources, the antiviral properties of methanol and aqueous extracts
obtained from Ballota glandulosissima
Hub.-Mor. & Patzak were evaluated by Colorimetric XTT test against
Respiratory syncytial virus (RSV). The concentration required to provide 50%
protection against cytopathic effects caused by the virus was defined as EC₅₀,
the selectivity index (SI) was determined from the ratio of CC₅₀ (50
% Cytotoxic concentration) to EC₅₀. The results showed that both the
methanol (EC₅₀ = 12.45 µg/mL; SI = 24.84) and aqueous extracts (EC₅₀
= 19.12 µg/mL; SI = 24.59) of B.
glandulosissima had almost the same strong anti-RSV activity as well as
ribavirin, used as a positive control against RSV (EC₅₀= 3.25
µg/mL, SI = 34.89). In conclusion, we can say that B. glandulosissima extracts are worthy of further studies in order
to develop an alternative to the drugs used in clinical practice against RSV.
This is the first report on the anti-RSV activity of B. glandulosissima.

Keywords

Ballota glandulosissima, methanol and aqueous extracts, antiviral activity, respiratory syncytial virus

Supporting Institution

Selçuk University, Scientific Research Projects Coordinating Office

Project Number

SÜ-BAP-16401077

References

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2. Arita, M., Philipov, S. & Galabov, A.S. 2015. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A. Microbiology and Immunulogy, 59(6): 338-347.
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5. Chiang, L.C., Chiang, W., Chang, M.Y., Ng, L.T. & Lin, C.C. 2002. Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Research, 55: 53-62.
6. Chin, J., Magoffin, R.L., Shearer, L.A., Schieble, J.H. & Lennette, EH. 1969. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a paediatric population. American Journal of Epidemiology, 89: 449-463.
7. Çitoğlu, G., Tanker, M. & Sever, B. 1999. Note flavonoid aglycones from B. saxatilis subsp. saxatilis. Pharmaceutical Biology, 37: 158-160.
8. Çitoğlu, G., Tanker, M., Sever, B., Englert, J., Anton, R. & Altanlar, N. 1998. Antibacterial activities of diterpenoids isolated from B. saxatilis subsp. saxatilis. Planta Medica, 64: 484-485.
9. Cos, P., Vlietinck, A.J., Vanden Berghe, D. & Maes, L. 2006. Anti-infective potential of natural products: how to develop a stronger in vitro ‘proof-of concept’. Journal of Ethnopharmacology, 106: 290-302.
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14. Eryaşar, P. & Tuzlacı, E. 1998. Gönen (Balıkesir) halk hekimliğinde kullanılan bitkiler, 95-102. Paper presented at XII. Bitkisel İlaç Hammaddeleri Toplantısı, 20-22 May, Hacettepe, Ankara-Turkey.
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28. Ma, S.C., Du, J., But, P.P.H., Deng, X.L., Zhang, Y.W., Ooi, V.E.C., Xu, H.X., Lee, S.H.S. & Lee, S.F. 2002. Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of Ethnopharmacology, 79: 205-211.
29. MacDonald, NE., Hall, CB., Suffin, SC., Alexson, C., Harris, PJ. & Manning, JA. 1982. Respiratory syncytial virus infection in infants with congenital heart disease. New England of Journal Medicine, 307: 397-400.
30. Meriçli, A.H., Meriçli, F. & Tuzlacı, E. 1988. Flavonoids of Ballota acetabulosa. Acta Pharmaceutica Turcica, 30: 143-144.
31. Miyazawa, M., Okuno, Y., Nakamura, S. & Kosaka, H. 2000. Antimutagenic activity of flavonoids from Pogostemon cablin. Journal of Agricultural and Food Chemistry, 48(3): 642-647.
32. Ninomiya, Y., Aoyama, M., Umeda, I., Suhara, Y. & Ishitsuka, H. 1985. Comparative studies on the modes of action of the Antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4’,6-dichloroflavan and enviroxime. Antimicrobial Agents and Chemotherapy, 27(4): 595-599.
33. Orabi, K.Y., Mossa, J.S., Muhammed, I., Alloush, M.H., Galal, A.M., El-Feraly, F.S. & McPhail, E.T. 2000. New eudesmane sesquiterpene from Plectranthus cylindraceus. Journal of Natural Products, 63: 1665-1668.
34. Özbek, H., Saltan Çitoğlu, G., Dülger, H., Uğraş, S. & Sever, B. 2004. Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. Journal of Ethnopharmacology, 95: 143-149.
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38. Rigano, D., Marrelli, M., Formisano, C., Menichini, F., Senatore, F., Bruno, M. & Conforti, F. 2016. Phytochemical profile of three Ballota species essential oils and evaluation of the effects on human cancer cells. Natural Product Research, 17: 1-9.
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40. Sakakibara, M., Difeo, D., Nakatani, J.N., Timmermann, B. & Mabry, T.S. 1976. Flavonoid methyl ethers on the external leaf surface of Larrea tridentata and Larrea divaricata. Phytochemistry, 15: 727-731.
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Year 2019, , 121 - 127, 15.10.2019

Hasan Hüseyin Doğan , Rüstem Duman

https://doi.org/10.23902/trkjnat.543382

Cited By: 1

Abstract

Doğal kaynaklardan yeni ve etkili antiviral etkenler
bulmak amacıyla yapılan bu çalışmada, Ballota
glandulosissima Hub.-Mor. &
Patzak’dan elde edilen metanol ve su ekstraktlarının antiviral özellikleri
Respiratuvar Sinsityal Virus (RSV)’una karşı kolorimetrik XTT testi ile
değerlendirilmiştir. Virüsün neden olduğu sitopatik etkilere karşı %50 koruma
sağlaması için gerekli konsantrasyon EC₅₀ olarak tanımlanmış, CC₅₀
(%50 Sitotoksik Konsantrasyon)’nin EC₅₀’ye oranından da seçicilik
indeksi (SI) belirlenmiştir. Araştırma sonucunda, B. glandulosissima’nın
hem metanol (EC₅₀ = 12.45 µg/mL; SI = 24.84) hem de su ekstraktının
(EC₅₀ = 19.12 µg/mL; SI = 24.59) RSV’ye karşı; pozitif kontrol
olarak kullanılan ribavirin (EC₅₀= 3.25 µg/mL, SI = 34.89)’e göre
önemli sayılabilecek oranda anti-RSV aktiviteye sahip olduğu tespit edilmiştir.
Sonuç olarak, B. glandulosissima ekstraktlarının, RSV’ye karşı klinikte kullanılan
ilaçlara karşı bir alternatif olarak geliştirilebilmesi için; daha ileri
çalışmalara layık olduğunu söyleyebiliriz. Bu çalışma, B. glandulosissima’nın anti-RSV aktivitesine yönelik ilk rapordur.

Project Number

SÜ-BAP-16401077

References

1. Andrighetti-Fröhmer, C.R., Antonio, R.V., Creczynski-Pasa, T.B., Barardi, C.R.M. & Simões, C.M.O. 2003. Cytotoxicity and potential antiviral evaluation of violacein produced by Chromobacterium violaceum. Memórias do Instituto Oswaldo Cruz, 98: 843-848.
2. Arita, M., Philipov, S. & Galabov, A.S. 2015. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A. Microbiology and Immunulogy, 59(6): 338-347.
3. Baytop, T. 1984. Türkiye’de Bitkilerle Tedavi. İstanbul Üniversitesi Yayınları, İstanbul, 371 pp.
4. Chattopadhyay, D., Chawla-Sarkar, M., Chatterjee, T., Dey, R.S., Bag, P., Chakraborti, S. & Khan, M.T.H. 2009. Recent advancements for the evaluation of antiviral activities of natural products. New Biotechnology, 25: 347-368.
5. Chiang, L.C., Chiang, W., Chang, M.Y., Ng, L.T. & Lin, C.C. 2002. Antiviral activity of Plantago major extracts and related compounds in vitro. Antiviral Research, 55: 53-62.
6. Chin, J., Magoffin, R.L., Shearer, L.A., Schieble, J.H. & Lennette, EH. 1969. Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a paediatric population. American Journal of Epidemiology, 89: 449-463.
7. Çitoğlu, G., Tanker, M. & Sever, B. 1999. Note flavonoid aglycones from B. saxatilis subsp. saxatilis. Pharmaceutical Biology, 37: 158-160.
8. Çitoğlu, G., Tanker, M., Sever, B., Englert, J., Anton, R. & Altanlar, N. 1998. Antibacterial activities of diterpenoids isolated from B. saxatilis subsp. saxatilis. Planta Medica, 64: 484-485.
9. Cos, P., Vlietinck, A.J., Vanden Berghe, D. & Maes, L. 2006. Anti-infective potential of natural products: how to develop a stronger in vitro ‘proof-of concept’. Journal of Ethnopharmacology, 106: 290-302.
10. Davis, P.H. 1982. Flora of Turkey and the East Aegean Islands. Edinburgh University Press, Edinburg, volume 7, 156-160 pp.
11. Dubovi, E.J., Geratz, J.D., Shaver, S.R. & Tidwell, R.R. 1981. Inhibition of respiratory syncytial virus-host cell interactions by mono and diamidines. Antimicrobial Agents and Chemotherapy, 19: 649-656.
12. Englund, J.A., Sullivan, C.J., Jordan, M.C., Dehner, L.P., Verecellotti, G.M. & Balfour, F. 1988. Respiratory syncytial virus infection in immunocompromised adults. Annals of Internal Medicine, 109: 203-208.
13. Erdoğan-Orhan, I., Sever-Yılmaz, B., Altun, M.L. & Saltan Çitoğlu, G. 2010. Radical quenching activity, ferric reduction antioxidant power, and ferrous ion-chelating capacity of Ballota species and their total phenol and flavonoid contents. Journal of Medicinal Food, 13(6): 1537-1543.
14. Eryaşar, P. & Tuzlacı, E. 1998. Gönen (Balıkesir) halk hekimliğinde kullanılan bitkiler, 95-102. Paper presented at XII. Bitkisel İlaç Hammaddeleri Toplantısı, 20-22 May, Hacettepe, Ankara-Turkey.
15. Eskiocak, U., İşeri, O.D., Kars, M.D., Biçer, A. & Gündüz, U. 2008. Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells: an experimental study. Chemotherapy, 54: 209-216.
16. Fraser, A.W. & Lewis, J.R. 1973. Two flavonols from Euodia glabra. Phytochemistry 12: 1787-1789.
17. Garnier, G., Debraux, G. & Bezanger-Beauquesne, L. 1961. Ressources Medicinales de la Flöre Française. Vigot Freres Editeurs, Paris, 1156-1158 pp.
18. Greuter, W. & Raus, T. 1998. Med-checklist Notulae, 17. Willdenowia, 28: 163-174.
19. Güner, A., Aslan, S., Ekim, T., Vural, M & Babaç, M.T. (edlr.) (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler). Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını.
20. Harrington, R.D., Hooton, T.M., Hackman, R.C., Storch, G.A., Osborne, B., Gleaves, C.A., Benson, A. & Meyers, JD. 1992. An outbreak of respiratory syncytial virus in bone marrow transplant centre. Journal of Infectious Diseases, 165: 987-993.
21. Hruska, J.F., Morrow, P.E., Suffin, S.C. & Douglas, R.G. 1982. In vivo inhibition of respiratory syncytial virus by ribavirin. Antimicrobial Agents and Chemotherapy, 21: 125-130.
22. Ishitsuka, H., Ninomiya, Y. & Suhara, Y. 1986. Molecular basis of drug resistance to new antirhinovirus agents. The Journal of Antimicrobial Chemotherapy, 18 Suppl B: 11-18.
23. Kaerber, G. 1964. Diagnostic procedures for virus and rickettsial disease. Public Health Association, 3: 48-50.
24. Kim, H.W., Canchola, J.G., Brandt, C.D., Pyles, G., Chanock, R.M., Jensen, K. & Parrott, R.H. 1969. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. American Journal of Epidemiology, 89: 422-434.
25. Kimura, K., Mori, S., Tomita, K., Ohno, K., Takahashi, K., Shigeta, S. & Terada, M. 2000. Antiviral activity of NMSO3 against respiratory syncytial virus infection in vitro and in vivo. Antiviral Research 47: 41-51.
26. Kneyber, M.C.J., Mou, H.A. & Groot, R.D. 2000. Treatment and prevention of respiratory syncytial virus infection. European Journal of Paediatrics, 159: 339-411.
27. Lewinsohn, D.M., Bowden, R.A., Mattson, D. & Crawford, S.W. 1996. Phase I study of intravenous ribavirin treatment of respiratory syncytial virus pneumonia after marrow transplantation. Antimicrobial Agents and Chemotherapy, 40: 2555-2557.
28. Ma, S.C., Du, J., But, P.P.H., Deng, X.L., Zhang, Y.W., Ooi, V.E.C., Xu, H.X., Lee, S.H.S. & Lee, S.F. 2002. Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of Ethnopharmacology, 79: 205-211.
29. MacDonald, NE., Hall, CB., Suffin, SC., Alexson, C., Harris, PJ. & Manning, JA. 1982. Respiratory syncytial virus infection in infants with congenital heart disease. New England of Journal Medicine, 307: 397-400.
30. Meriçli, A.H., Meriçli, F. & Tuzlacı, E. 1988. Flavonoids of Ballota acetabulosa. Acta Pharmaceutica Turcica, 30: 143-144.
31. Miyazawa, M., Okuno, Y., Nakamura, S. & Kosaka, H. 2000. Antimutagenic activity of flavonoids from Pogostemon cablin. Journal of Agricultural and Food Chemistry, 48(3): 642-647.
32. Ninomiya, Y., Aoyama, M., Umeda, I., Suhara, Y. & Ishitsuka, H. 1985. Comparative studies on the modes of action of the Antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4’,6-dichloroflavan and enviroxime. Antimicrobial Agents and Chemotherapy, 27(4): 595-599.
33. Orabi, K.Y., Mossa, J.S., Muhammed, I., Alloush, M.H., Galal, A.M., El-Feraly, F.S. & McPhail, E.T. 2000. New eudesmane sesquiterpene from Plectranthus cylindraceus. Journal of Natural Products, 63: 1665-1668.
34. Özbek, H., Saltan Çitoğlu, G., Dülger, H., Uğraş, S. & Sever, B. 2004. Hepatoprotective and anti-inflammatory activities of Ballota glandulosissima. Journal of Ethnopharmacology, 95: 143-149.
35. Patzak, V.A. 1958. Revision der gattung Ballota section Acanthoprasium und section Beringeria. Annalen des Naturhistorischen Museums in Wien, 62: 57-86.
36. Patzak, V.A. 1960. Zwei nene Ballota-arten aus der Türkei nebst einem nachtrag zur gattung Ballota. Annalen des Naturhistorischen Museums in Wien, 64: 42-56.
37. Pérez, L. & Carrasco, L. 1992. Lack of direct correlation between p220 cleavage and the Shut-off of host translation after Poliovirus infection. Virology, 189: 178-186.
38. Rigano, D., Marrelli, M., Formisano, C., Menichini, F., Senatore, F., Bruno, M. & Conforti, F. 2016. Phytochemical profile of three Ballota species essential oils and evaluation of the effects on human cancer cells. Natural Product Research, 17: 1-9.
39. Rukunga, G. & Simons, A.J. (2006). The potential of plants as a source of antimalarial agents, A review, 72pp, Africa herbal antimalarial meeting, CDE and ICRAF, World Agroforestry Centre, Nairobi, Kenya.
40. Sakakibara, M., Difeo, D., Nakatani, J.N., Timmermann, B. & Mabry, T.S. 1976. Flavonoid methyl ethers on the external leaf surface of Larrea tridentata and Larrea divaricata. Phytochemistry, 15: 727-731.
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There are 58 citations in total.

Details

Primary Language	English
Subjects	Structural Biology
Journal Section	Research Article/Araştırma Makalesi
Authors	Hasan Hüseyin Doğan 0000-0001-8859-0188 Rüstem Duman 0000-0002-2320-7448
Project Number	SÜ-BAP-16401077
Publication Date	October 15, 2019
Submission Date	March 22, 2019
Acceptance Date	September 11, 2019
Published in Issue	Year 2019

Cite

APA	Doğan, H. H., & Duman, R. (2019). EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV). Trakya University Journal of Natural Sciences, 20(2), 121-127. https://doi.org/10.23902/trkjnat.543382
AMA	Doğan HH, Duman R. EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV). Trakya Univ J Nat Sci. October 2019;20(2):121-127. doi:10.23902/trkjnat.543382
Chicago	Doğan, Hasan Hüseyin, and Rüstem Duman. “EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota Glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)”. Trakya University Journal of Natural Sciences 20, no. 2 (October 2019): 121-27. https://doi.org/10.23902/trkjnat.543382.
EndNote	Doğan HH, Duman R (October 1, 2019) EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV). Trakya University Journal of Natural Sciences 20 2 121–127.
IEEE	H. H. Doğan and R. Duman, “EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)”, Trakya Univ J Nat Sci, vol. 20, no. 2, pp. 121–127, 2019, doi: 10.23902/trkjnat.543382.
ISNAD	Doğan, Hasan Hüseyin - Duman, Rüstem. “EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota Glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)”. Trakya University Journal of Natural Sciences 20/2 (October 2019), 121-127. https://doi.org/10.23902/trkjnat.543382.
JAMA	Doğan HH, Duman R. EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV). Trakya Univ J Nat Sci. 2019;20:121–127.
MLA	Doğan, Hasan Hüseyin and Rüstem Duman. “EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota Glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)”. Trakya University Journal of Natural Sciences, vol. 20, no. 2, 2019, pp. 121-7, doi:10.23902/trkjnat.543382.
Vancouver	Doğan HH, Duman R. EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. & Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV). Trakya Univ J Nat Sci. 2019;20(2):121-7.

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