CURRENT STATUS OF GERMLINE STEM CELLS IN ADULT MAMMALIAN OVARY

Year 2019, Special Issue: Stem Cell, 63 - 66, 01.02.2019

Enes Taylan , Yodo Sugishita Kenan Kirteke

https://doi.org/10.23902/trkjnat.483495

Abstract

The evolutionary and biological mechanisms underlying female
reproductive aging have long been a matter of interest. Reproductive biologists
have tackled with the relatively limited fertile period in female lifespan
compared to male fertility that continues until the late ages. For more than
five decades, it has been believed that females are born with a fixed number of
germ cells that constitute ovarian follicle reserve and depletion of this
reserve causes menopause. However, researchers recently reported findings that
support the presence of oogenesis in postnatal mammalian ovaries, which caused
a paradigm shift in our current knowledge of reproductive biology. In this
minireview, we provide a brief history of one of the central dogmas in
reproductive biology and subsequently present recent studies on the existence
of germline stem cells in the mammalian ovary.

Keywords

Ovary, fertility preservation, stem cells, female germline

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