In vitro release kinetic and in vivo field trial performance of a long term sustained-release bolus for saanen goats

Yıl 2024, Cilt: 8 Sayı: 4, 712 - 719, 31.10.2024

Gürbüz Çomak , Murat Durmuş , İbrahim Erez

https://doi.org/10.31127/tuje.1475109

Öz

Controlled release studies of sustained-release boluses are of critical importance as their application in ruminants has been varying from providing mineral and vitamin support to prevent the development of clinical problems such as hypocalcemia, ketosis, and others. This study examines both morphological and kinetic release of a sustained-release bolus and its performance study on Saanen goats. The bolus was studied by the means of continued flow rig which the artificial rumen saliva was pumped through with a flow rate of 3 mL/min. In addition to zero order kinetic, there was no crack or deformation observed through the immersion times but erosion was present. Field trials conducted with a number of 28 Saanen goats show that the treatment group is of higher multiple birth rates than the control group. No triple birth was observed on the control group. However, the rate of change in the body weight significantly increased in twins and triplets compared to the control group.

Anahtar Kelimeler

Bolus, Sustained-release, Saanen goat, Release kinetic

Destekleyen Kurum

The authors declare that no funds, grants, or other supports were received during the preparation of this manuscript.

Teşekkür

Authors would like to thank to Çukurova University Faculty of Agriculture Dairy Goat Breeding Research and Application Farm for collecting data and analysis.

Kaynakça

• Lawson, D.C., Ritchie, N. S., Parkins, J. J., Hemingway, R. G., & Gresham, H. R. (1990a). Use of a sustained release bolus for enhancing selenium status of cattle. Veterinary Record, 127, 67-68.
• Lawson, D. C., Hemingway, R. G., Parkins, J. J., & Ritchie, N. S. (1990b). Field trials with multi-trace element/vitamin boluses for grazing cattle. Journal of the Science of Food and Agriculture, 50, 282-283.
• Parkins, J. J., Hemingway, R. G., Lawson, D. C., & Ritchie, N. S. (1994). The effectiveness of copper oxide powder as a component of a sustained-release multitrace element and vitamin rumen bolus system for cattle. British Veterinary Journal, 150, 547-553.
• Ruan, X., Gao, X., Gao, Y., Peng, L., Ji, H., Guo, D., & Jiang, S. (2018). Preparation and in vitro release kinetics of ivermectin sustained-release bolus optimized by response surface methodology. PeerJ, 6 . https://doi.org/10.7717/peerj.5418
• He, R., Wang, S., Yao, Y., & Wang, Y. (2000). Cu, Co and Se nutritive value of compound trace elements controlled-release boluses for grazing ruminants. Ying Yong Sheng Tai Xue Bao, 11, 258-260.
• Kosgey, I. S., & Okeyo, A. M. (2007). Genetic improvement of small ruminants in low-input, smallholder production systems: Technical and infrastructural issues. Small Ruminant Research, 70, 76-88.
• Sadjadian, R., Seifi, H. A., Mohri, M., Naserian, A. A., & Farzaneh, N. (2013). Variations of energy biochemical metabolites in periparturient dairy Saanen goats. Comparative Clinical Pathology, 22, 449–456. https://doi.org/10.1007/s00580-012-1431-8
• Garcia, A. B., Angeli, N., Machado, L., De Cardoso, F. C., & Gonzalez, F. (2015). Relationships between heat stress and metabolic and milk parameters in dairy cows in Southern Brazil. Tropical Animal Health and Production, 47, 889–894. https://doi.org/10.1007/s11250-015-0804-9
• Kamal, R., Dutt, T., Patel, M., Dey, A., Bharti, P. K., & Chandran, P. C. (2018). Heat stress and effect of shade materials on hormonal and behavior response of dairy cattle: A review. Tropical Animal Health and Production, 50, 701–706. https://doi.org/10.1007/s11250-018-1542-6
• Damarany, A. I., & Ghanem, N. (2020). Effect of flunixine meglumine and aspirin administration on conception rate and estrous cycle characteristics of Egyptian Baladi cows during the hot season. Tropical Animal Health and Production, 52, 2969–2976. https://doi.org/10.1007/s11250-020-02314-6
• Hamzaoui, S., Salama, A. A. K., Albanell, E., Such, X., & Caja, G. (2013). Physiological responses and lactational performances of late-lactation dairy goats under heat stress conditions. Journal of Dairy Science, 96, 6355–6365. https://doi.org/10.3168/jds.2013-6665
• Gwendolyn, L., Carroll, M. S., Matthews, N., Crist, M. A., Thomas, H., & Hartsfield, S. M. (2007). Behavioral, physiological and stress-related hormonal and metabolic responses to intravenous and epidural morphine in goats. International Journal of Applied Research in Veterinary Medicine, 5(2), 77-86.
• Darcan, N., & Güney, O. (2008). Alleviation of climatic stress of dairy goats in the Mediterranean climate. Small Ruminant Research, 74, 212-215.
• Lacetera, N., Bernabucci, U., Ronchi, B., & Nardone, A. (2003). Physiological and productive consequences of heat stress. The case of dairy ruminants. In Lacetera, N., Bernabucci, U., Khalifa, H. H., Ronchi, B., & Nardone, A. (Eds.), Proceedings of the Symposium on Interaction between Climate and Animal Production: EAAP Technical Series (No. 7, pp. 45-60).
• Zarbalizadeh-Saed, A., Seifdavati, J., Abdi-Benemar, H., Salem, A. Z. M., Barbabosa-Pliego, A., Camacho-Diaz, L. M., Fadayifar, A., & Seyed-Sharifi, R. (2020). Effect of slow-release pellets of selenium and iodine on performance and some blood metabolites of pregnant Moghani ewes and their lambs. Biological Trace Element Research, 195(2), 461–471. https://doi.org/10.1007/s12011-019-01853
• Robinson, J. J., Ashworth, C. J., Rooke, J. A., Mitchell, L. M., & McEvoy, T. G. (2006). Nutrition and fertility in ruminant livestock. Animal Feed Science and Technology, 126(3-4), 259–276.
• Kamiloğlu, N. N., Kacar, C., Güven, A., et al. (2017). Changes in lipid peroxidation, glutathione and fertility in Tuj sheep after combined administration of vitamin A and E and passive immunization with testosterone antibodies. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 23(3), 459–465.
• Smith, M. C., & Sherman, D. M. (2009). Goat Medicine. John Wiley & Sons. Vázquez-Armijo, J. F., Rojo, R., López, D., et al. (2011). Trace elements in sheep and goats reproduction: A review. Tropical and Subtropical Agroecosystems, 14(1), 1–13.
• McDougall, E. I. (1948). The composition and output of sheep’s saliva. Biochemical Journal, 43, 99–109. https://doi.org/10.1042/bj0430099
• Akan, A. E., & Ünal, F. (2021). An application to error and uncertainty analysis in industrial type dryer experiments. Turkish Journal of Engineering, 5(2), 80–86. https://doi.org/10.31127/tuje.679377
• AOAC. (2005). Official Methods of Analysis, 18th ed. Gaithersburg, Maryland, USA: Association of Official Analytical Chemists.
• Van Soest, P. J., Robertson, J. B., & Lewis, B. A. (1991). Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science, 74, 3583-3597.
• Luo, J., Goetsch, A. L., Nsahlai, I. V., Johnson, Z. B., Sahlu, T., Moore, J. E., Ferrell, C. L., Galyean, M. L., & Owens, F. N. (2004). Maintenance energy needs of goats: Predictions based on observations of heat and recovered energy. Small Ruminant Research, 53, 221–230.
• Salako, A. E., & Ngere, L. O. (2002). Application of multifactorial structural discriminant analysis in the morphometric structural differentiation of West African Dwarf and Yankassa sheep in Southwest Nigeria. Nigerian Journal of Animal Production, 29(2), 163–167.
• Takci, M., Develioğlu, İ., Pulat, H. F., & Demirci, H. E. (2023). Laboratory modeling and analysis of slopes of different geometry under the effect of precipitation. Turkish Journal of Engineering, 7(4), 349–357. https://doi.org/10.31127/tuje.1191246
• Cardinal, J. R. (1985). Controlled drug delivery: Veterinary applications. Journal of Controlled Release, 2, 393–403. https://doi.org/10.1016/0168-3659(85)90061-6
• Telfer, S. B. (1984). Controlled release glass (CRG)—Its action and application in sheep. Proceedings of the Sheep Veterinary Society, 8, 82–85.
• Yelten, A., Öztürk, M. H., & Yılmaz, S. (2022). 3D printing of PLA scaffolds for medical applications. Turkish Journal of Engineering, 6(4), 262–267. https://doi.org/10.31127/tuje.958192
• Hemingway, R. G., Parkins, J. J., & Ritchie, N. S. (1997). Sustained-release boluses to supply trace elements and vitamins to calves. Veterinary Journal, 153(2), 221–224.
• Kuru, M., Kuru, B. B., Sogukpinar, O., et al. (2020). Oestrus synchronisation with progesterone-containing sponge and equine chorionic gonadotropin in Pirlak ewes during the non-breeding season: Can Toryum improve fertility parameters? Journal of Veterinary Research, 64(4), 573–579.
• Aliarabi, H., Fadayifar, A., Alimohamady, R., & Dezfoulian, A. H. (2019). The effect of maternal supplementation of zinc, selenium, and cobalt as slow-release ruminal bolus in late pregnancy on some blood metabolites and performance of ewes and their lambs. Biological Trace Element Research, 187, 403–410.
• Bedwal, R., & Bahuguna, A. (1994). Zinc, copper and selenium in reproduction. Experientia, 50, 626–640.