SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL
Abstract
This study presents a detailed analysis of a dengue transmission model that incorporates two biologically motivated time delays, representing the intrinsic and extrinsic incubation periods in host-vector interactions. Based on a vector-host framework, the model examines the influence of key transmission parameters through sensitivity analysis and contour plots. The basic reproduction number $R_0$ is analytically derived and assessed for its dependence on epidemiologically significant factors. To curb disease spread, an optimal control problem is formulated by introducing three time-dependent control strategies: personal protection, vector control, and vector targeting efficiency. Employing Pontryagin’s Maximum Principle, the necessary conditions for optimality are established. Numerical simulations under various delay scenarios reveal that optimal control strategies significantly reduce both human and vector infections. However, the presence and magnitude of delays affect the speed and efficacy of intervention. The findings emphasize the critical role of accounting for biological delays and implementing targeted controls in designing effective dengue prevention strategies.
Keywords
References
- [1] WHO, (2009), Dengue: Guidelines for diagnosis, treatment, prevention and control,world health organization. Accessed on March 20, 2024.URL: https://www.who.int/publications/i/item/9789241547871
- [2] Yang, C. and Wang, J., (2020), A mathematical model for the novel coronavirus epidemic in Wuhan, China, Mathematical biosciences and engineering 17(3), pp.2708– 2724.
- [3] Ndii, M. Z., (2017), Mathematical modelling to investigate a Wolbachia intervention to reduce dengue transmission, arXiv (Cornell University) .
- [4] Supriatna, A., Soewono, E. and Van Gils, S., (2008), A two-age-classes dengue transmission model, Mathematical biosciences 216(1), pp.114–121.
- [5] Ndii, M. Z., Allingham, D., Hickson, R. I. and Glass, K., (2016b), The effect of- Wolbachiaon dengue dynamics in the presence of two serotypes of dengue: symmetric and asymmetric epidemiological characteristics, Epidemiology and infection 144(13), pp.2874–2882.
- [6] Ndii, M. Z., Allingham, D., Hickson, R. and Glass, K., (2016a), The effect of Wolbachia on dengue outbreaks when dengue is repeatedly introduced, Theoretical population biology 111, pp.9–15.
- [7] Dorigatti, I., Aguas, R., Donnelly, C. A., Guy, B., Coudeville, L., Jackson, N., Saville, M. and Ferguson, N. M., (2015), Modelling the immunological response to a tetravalent dengue vaccine from multiple phase-2 trials in Latin America and South East Asia, Vaccine 33(31), pp.3746–3751.
- [8] Ferguson, N. M., Rodriguez-Barraquer, I., Dorigatti, I., Mier-Y-Teran-Romero, L., Laydon, D. J. and Cummings, D. A. T., (2016), Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment, Science 353(6303), pp.1033–1036.
Details
Primary Language
English
Subjects
Ordinary Differential Equations, Difference Equations and Dynamical Systems, Dynamical Systems in Applications
Journal Section
Research Article
Publication Date
September 7, 2026
Submission Date
June 2, 2025
Acceptance Date
September 1, 2025
Published in Issue
Year 2026 Volume: 16 Number: 9
APA
Raj, M. P., Venkatesh, A., Arun Kumar, K., & Manivel, M. (2026). SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL. TWMS Journal of Applied and Engineering Mathematics, 16(9), 1104-1117. https://izlik.org/JA83RX56XL
AMA
1.Raj MP, Venkatesh A, Arun Kumar K, Manivel M. SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL. JAEM. 2026;16(9):1104-1117. https://izlik.org/JA83RX56XL
Chicago
Raj, M. Prakash, A Venkatesh, K. Arun Kumar, and M Manivel. 2026. “SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL”. TWMS Journal of Applied and Engineering Mathematics 16 (9): 1104-17. https://izlik.org/JA83RX56XL.
EndNote
Raj MP, Venkatesh A, Arun Kumar K, Manivel M (September 1, 2026) SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL. TWMS Journal of Applied and Engineering Mathematics 16 9 1104–1117.
IEEE
[1]M. P. Raj, A. Venkatesh, K. Arun Kumar, and M. Manivel, “SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL”, JAEM, vol. 16, no. 9, pp. 1104–1117, Sept. 2026, [Online]. Available: https://izlik.org/JA83RX56XL
ISNAD
Raj, M. Prakash - Venkatesh, A - Arun Kumar, K. - Manivel, M. “SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL”. TWMS Journal of Applied and Engineering Mathematics 16/9 (September 1, 2026): 1104-1117. https://izlik.org/JA83RX56XL.
JAMA
1.Raj MP, Venkatesh A, Arun Kumar K, Manivel M. SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL. JAEM. 2026;16:1104–1117.
MLA
Raj, M. Prakash, et al. “SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL”. TWMS Journal of Applied and Engineering Mathematics, vol. 16, no. 9, Sept. 2026, pp. 1104-17, https://izlik.org/JA83RX56XL.
Vancouver
1.M. Prakash Raj, A Venkatesh, K. Arun Kumar, M Manivel. SENSITIVITY AND OPTIMIZING DENGUE CONTROL IN A TWO-TIME-DELAY TRANSMISSION MODEL. JAEM [Internet]. 2026 Sep. 1;16(9):1104-17. Available from: https://izlik.org/JA83RX56XL