Antideprasan İlaçların Etken Maddelerinin Adsorpsiyonu: Kinetik ve İzotermi

Yıl 2018, Cilt: 10 Sayı: 1, 1 - 11, 29.01.2017

Orhan Baytar

https://doi.org/10.29137/umagd.419657

Öz

Bu
çalışmada bir önceki çalışmamız elde ettiğimiz yüksek yüzey alana sahip aktif
karbon kullanılarak venlafaxine ve doxylamine antiderprasan ilaçların etken
maddesinin adsorpsiyonu incelenmiştir. Adsorpsiyon çalışmalarında çözelti
başlangıç pH, çözelti başlangıç konsantrasyonu ve aktif karbon miktarı
parametrelerin etkisi incelenmiştir. Adsorpsiyonun denge verileri Langmuir ve
freundlich izotermlerine uygulanmış ve en iyi Langmuir izotermine uyduğu
belirlenmiştir. Langmuir izotermine qmax venlafaxine ve doxylamine maddeleri
için sırasıyla 8.764 ve 10.764 mg/g olduğu tespit edilmiştir. İlaç etken
maddelerinin adsorpsiyon kinetiği yalancı birinci derece ve yalancı ikinci
derece kinetik modeller için hesaplanmış ve en iyi yalancı ikinci derece
kinetik model olduğu belirlenmiştir.

Anahtar Kelimeler

Antideprasan, ilaç etken maddesi, adsorpsiyon, izoterm

Making Adsorption of Effective Agents of Antidepressıon Drugs: Kinetıc and Isotherm

Öz

In this study, the adsorption of the active
agent of venlafaxine and doxylamine antidepressant drugs was investigated by
using the high surface area active carbon obtained in our previous study. The
effects of initial pH of solution, initial concentration of solution and amount
of activated carbon were examined in adsorption experiments. The adsorption
equilibrium data were applied to the Langmuir and Freundlich isotherms and the
best Langmuir isotherm was determined. Langmuir isotherm was found as 8.764 and
10.764 for qmax venlafaxine and doxylamine substances, respectively. The
adsorption kinetics of the drug substance were calculated for pseudo first
order and pseudo second order kinetic models and it was determined to be the
best pseudo second order kinetic model.

Anahtar Kelimeler

Antidepressant, drug substance, adsorption, isotherm

Kaynakça

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