Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer

Muslih Ürün; Gürkan Güner; Yasin Sezgin; Emre Uysal; Yonca Yılmaz Ürün; Abdullah Sakin

doi:10.52976/vansaglik.1308883

Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer

Öz

Introduction: Although the incidence of gastric cancer has shown a significant decrease over the years, it remains the fourth leading cause of cancer-related deaths, resulting in more than 700,000 annual deaths worldwide. The main goal of metastatic gastric cancer treatment is to alleviate symptoms and, if feasible, improve survival. The purpose of our study was to compare the effectiveness of two chemotherapy regimens, FOLFIRI and paclitaxel, which are commonly used in the second-line treatment of metastatic gastric cancer. Material and Method: Patients over the age of 18 with a diagnosis of metastatic gastric carcinoma who were treated with either FOLFIRI or paclitaxel as second-line therapy were enrolled in our study. These two treatment groups were compared in terms of overall and progression-free survival. Results: A total of 99 patients were included. 56 (56.6%) patients had received FOLFIRI and 43 (43.3%) had received paclitaxel. The median overall survival for the entire cohort was 9 months: 10 months for FOLFIRI and 8 months for paclitaxel, with no statistically significant difference between them. In multivariate analysis, Eastern Cooperative Oncology Group (ECOG) performance status, body mass index, and number of chemotherapy cycles were identified as independent prognostic factors. Conclusion: We compared two commonly used regimens in the second-line treatment of metastatic gastric cancer, FOLFIRI and paclitaxel, in terms of overall and progression-free survival. There was no statistically significant difference between the two regimens. Both regimens can be considered as reasonable second-line treatment options. According to the results of our study, the choice of chemotherapy for second-line treatment should be made on an individual basis, considering factors such as the treatment received in the first-line, side effects, medication cost, and accessibility.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Klinik Tıp Bilimleri

Bölüm

Araştırma Makalesi

Yazarlar

Muslih Ürün ^*
0000-0002-9883-3398
Türkiye

Gürkan Güner
0000-0003-2275-1158
Türkiye

Yasin Sezgin
0000-0003-4122-8389
Türkiye

Emre Uysal
0000-0002-4737-4304
Türkiye

Yonca Yılmaz Ürün
0000-0001-6686-0300
Türkiye

Abdullah Sakin
0000-0003-2538-8569
Türkiye

Yayımlanma Tarihi

30 Ağustos 2023

Gönderilme Tarihi

2 Haziran 2023

Kabul Tarihi

9 Ağustos 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 16 Sayı: 2

DOI

https://doi.org/10.52976/vansaglik.1308883

IZ

https://izlik.org/JA58SD38YW

Kaynak Göster

RIS / Bibtex

APA

Ürün, M., Güner, G., Sezgin, Y., Uysal, E., Yılmaz Ürün, Y., & Sakin, A. (2023). Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer. Van Sağlık Bilimleri Dergisi, 16(2), 176-182. https://doi.org/10.52976/vansaglik.1308883

AMA

1.Ürün M, Güner G, Sezgin Y, Uysal E, Yılmaz Ürün Y, Sakin A. Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer. Van Sağ Bil Derg. 2023;16(2):176-182. doi:10.52976/vansaglik.1308883

Chicago

Ürün, Muslih, Gürkan Güner, Yasin Sezgin, Emre Uysal, Yonca Yılmaz Ürün, ve Abdullah Sakin. 2023. “Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer”. Van Sağlık Bilimleri Dergisi 16 (2): 176-82. https://doi.org/10.52976/vansaglik.1308883.

EndNote

Ürün M, Güner G, Sezgin Y, Uysal E, Yılmaz Ürün Y, Sakin A (01 Ağustos 2023) Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer. Van Sağlık Bilimleri Dergisi 16 2 176–182.

IEEE

[1]M. Ürün, G. Güner, Y. Sezgin, E. Uysal, Y. Yılmaz Ürün, ve A. Sakin, “Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer”, Van Sağ Bil Derg, c. 16, sy 2, ss. 176–182, Ağu. 2023, doi: 10.52976/vansaglik.1308883.

ISNAD

Ürün, Muslih - Güner, Gürkan - Sezgin, Yasin - Uysal, Emre - Yılmaz Ürün, Yonca - Sakin, Abdullah. “Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer”. Van Sağlık Bilimleri Dergisi 16/2 (01 Ağustos 2023): 176-182. https://doi.org/10.52976/vansaglik.1308883.

JAMA

1.Ürün M, Güner G, Sezgin Y, Uysal E, Yılmaz Ürün Y, Sakin A. Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer. Van Sağ Bil Derg. 2023;16:176–182.

MLA

Ürün, Muslih, vd. “Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer”. Van Sağlık Bilimleri Dergisi, c. 16, sy 2, Ağustos 2023, ss. 176-82, doi:10.52976/vansaglik.1308883.

Vancouver

1.Muslih Ürün, Gürkan Güner, Yasin Sezgin, Emre Uysal, Yonca Yılmaz Ürün, Abdullah Sakin. Comparison of the Efficacy of FOLFIRI and Paclitaxel Chemotherapy Regimens in the Second Line Treatment of Metastatic Gastric Cancer. Van Sağ Bil Derg. 01 Ağustos 2023;16(2):176-82. doi:10.52976/vansaglik.1308883