Heat stress, intestinal barrier disruption and calves: multidisciplinary perspective field study

Abstract

Intestinal barrier might be deteriorated by heat stress (hs) that is important disruption factor affected animal productivity, as resulted leaky gut in cattle. Therefore, the aim of this study is to demonstrate that the intestinal barrier is disrupted by hs detected by the zonulin, as an intestinal permeability biomarker. The study was conducted in local farm in the Aydın Province of Turkey in August that had the average highest temperature [41.10C (36-440C)] with %36 humidity recorded by the meteorological data. Further, serum zonulin levels were assessed by ELISA. Serum zonulin (ng/ml) levels increased (60,07 ± 21,20) at mid night 00.00 am in contrast to mid-day values at 12.00 pm (34,60 ± 10,90) (p=0,018). Regarding increased zonulin levels indicated that distrupted intestinal barrier with increasing intestinal permeability and it might be affected to reduced productivity of lactation cattle with hs during hotter summer months in Aegon Region in Turkey. Therefore, preventive measures should be taken reflected to hs.

Keywords

• cattle
• heat stress
• leaky gut
• zonulin

Sıcaklık stresi, bağırsak bariyerinin bozulması ve buzağılar: saha çalışmasına multidisipliner bakış

Abstract

Sığırlarda sızıntılı bağırsağa neden olarak hayvan sağlığını olumsuz etkileyen en önemli faktör olan sıcaklık stresi (hs) ile bağırsak bütünlüğü bozulabilmektedir. Bu sebeple bu araştırmanın amacı, bağırsak geçirgenlik belirteci olan zonulin ile hs’ nin bağırsak bariyer bütünlüğünü bozduğunun gösterilmesidir. Çalışma meteorolojik rapora göre en yüksek sıcaklık [41.10C (36-440C)] ile %36 nem oranının ölçüldüğü Ağustos ayında, Türkiye’ nin Aydın İli’ nde gerçekleştirildi. Beraberinde serum zonulin seviyesi ELISA metodu ile değerlendirildi. Serum zonulin seviyesi (ng/ml) günortası 12.00 pm değeri (34,60 ± 10,90) ile karşılaştırıldığında gece yarısı 00.00 am’ de (60,07 ± 21,20) artış gösterdi (p=0,018). Artan zonulin seviyelerine göre artan bağırsak geçirgenliği ile bağırsak bariyer bütünlüğünün bozulduğu ve hs’ nin Türkiye’ de Ege Bölgesi’ nde en sıcak yaz aylarında laktasyon sığırlarında verimin azalmasına neden olarak etkileyebileceği görüldü. Bu sebeple alınan tedbirler mutlaka hs’ ni yansıtmalıdır.

Keywords

• sığır
• sıcaklık stresi
• sızıntılı bağırsak
• zonulin

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