Comparison of the effects of Crystalin® spray and Froximun® powder on the healing of open wounds in cats and dogs

Volkan Havabilen; Muharrem Erol

doi:10.31797/vetbio.1619132

Comparison of the effects of Crystalin® spray and Froximun® powder on the healing of open wounds in cats and dogs

Abstract

Many topical products are recommended to accelerate wound healing, particularly for patients with chronic or non-healing wounds or when factors delaying healing are present. The potential benefits of these products must outweigh their cytotoxic effects. Hypochlorous acid and clinoptilolite are commonly used for this purpose. This study aimed to comparatively evaluate the effects of Crystalin® Spray and Froximun® Powder, containing these active ingredients, on wound healing. The study involved 12 owned animals (cats and dogs) of various ages, breeds, sexes, and weights. The animals were divided into two groups and treated with either Crystalin® Spray or Froximun® Powder. Wound healing in the Crystalin® Spray group was analyzed using Friedman’s test, revealing significant daily wound area reduction (p=0.001). Statistically significant healing was observed as early as the 19th day (p<0.05). Similarly, the Froximun® Powder group showed significant wound area reduction (p=0.001). However, a comparison between the two groups revealed no statistically significant difference in wound healing rates (p>0.05). While both products demonstrated effectiveness, Hypochlorous acid preparations offer a cost-effective option for prolonged treatment and are easier for both veterinarians and pet owners to apply. Conversely, clinoptilolite in powder form requires bandaging for effective application, which may pose challenges for pet owners to maintain treatment continuity outside clinical settings.

Keywords

References

Akdağ, E. (2014). Canine parvoviral enteritis’li köpeklerde klinoptilolit’in sağaltım etkinliğinin araştırılması [PhD Thesis]. Adnan Menderes Üniversitesi.
Aksoy, S. Ö., Tunk, C. O., Sevinç, A. İ., & Durak, M. G. (2019). Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 33(2), 139–147. https://doi.org/10.5505/deutfd.2019.86619
Alam, H. B., Burris, D., DaCorta, J. A., & Rhee, P. (2005). Hemorrhage control in the battlefield: role of new hemostatic agents. Military Medicine, 170(1), 63–69. https://doi.org/10.7205/MILMED.170.1.63
Anderson, D. (1996). Wound management in small animal practice. In Practice, 18(3), 115–128. https://doi.org/10.1136/inpract.18.3.115
Atiyeh, B. S., Dibo, S. A., & Hayek, S. N. (2009). Wound cleansing, topical antiseptics and wound healing. International Wound Journal, 6(6), 420–430. https://doi.org/10.1111/j.1742-481X.2009.00639.x
Davidson, J. R. (2015). Current concepts in wound management and wound healing products. Veterinary Clinics of North America: Small Animal Practice, 45(3), 537–564. https://doi.org/10.1016/j.cvsm.2015.01.009
Erdoğan, S., Paşa, S., Erdoğan, H., Alıç Ural, D., Haydardedeoğlu, A. E., & Ural, K. (2018). Clinoptilolite application in left and right abomasal displacement. Van Veterinary Journal, 29(2), 71–75.
Fahie, M. A., & Shettko, D. (2007). Evidence-based wound management: A systematic review of therapeutic agents to enhance granulation and epithelialization. Veterinary Clinics of North America: Small Animal Practice, 37(3), 559–577. https://doi.org/10.1016/j.cvsm.2007.02.001

Fernandez, R., & Griffiths, R. (2012). Water for wound cleansing. Cochrane database of systematic reviews, 15(2), CD003861. https://doi.org/10.1002/14651858.CD003861.pub3
Gold, M. H., Andriessen, A., Dayan, S. H., Fabi, S. G., Lorenc, Z. P., & Henderson Berg, M.-H. (2017). Hypochlorous acid gel technology-Its impact on postprocedure treatment and scar prevention. Journal of Cosmetic Dermatology, 16(2), 162–167. https://doi.org/10.1111/jocd.12330
Grce, M., & Pavelić, K. (2005). Antiviral properties of clinoptilolite. Microporous and Mesoporous Materials, 79(1–3), 165–169. https://doi.org/10.1016/j.micromeso.2004.10.039
Gunaydin, M., Esen, S., Karadag, A., Unal, N., Yanik, K., Odabasi, H., & Birinci, A. (2014). In vitro antimicrobial activity of Medilox® super-oxidized water. Annals of Clinical Microbiology and Antimicrobials, 13(1), 29. https://doi.org/10.1186/1476-0711-13-29
Ivkovic, S., Deutsch, U., Silberbach, A., Walraph, E., & Mannel, M. (2004). Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: Effects on the immune system. Advances in Therapy, 21(2), 135–147. https://doi.org/10.1007/BF02850340
Kraljević Pavelić, S., Simović Medica, J., Gumbarević, D., Filošević, A., Pržulj, N., & Pavelić, K. (2018). Critical review on zeolite clinoptilolite safety and medical applications in vivo. Frontiers in Pharmacology, 9, 1350. https://doi.org/10.3389/fphar.2018.01350
Maeda, T., & Nosé, Y. (1999). A new antibacterial agent: antibacterial zeolite. Artificial Organs, 23(2), 129–130. https://doi.org/10.1046/j.1525-1594.1999.00751.x
Sampson, M. N., & Muir, A. V. G. (2002). Not all super-oxidized waters are the same. Journal of Hospital Infection, 52(3), 228–229. https://doi.org/10.1053/jhin.2002.1304
Selkon, J. B., Cherry, G. W., Wilson, J. M., & Hughes, M. A. (2006). Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers. Journal of Wound Care, 15(1), 33–37. https://doi.org/10.12968/jowc.2006.15.1.26861
Suarez-Arnedo, A., Torres Figueroa, F., Clavijo, C., Arbeláez, P., Cruz, J. C., & Muñoz-Camargo, C. (2020). An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays. PLOS ONE, 15(7), e0232565. https://doi.org/10.1371/journal.pone.0232565

Details

Primary Language

English

Subjects

Veterinary Surgery

Journal Section

Research Article

Authors

Volkan Havabilen This is me
0000-0002-7052-8260
Türkiye

Muharrem Erol ^*
0000-0003-0780-9067
Türkiye

Publication Date

August 31, 2025

Submission Date

January 14, 2025

Acceptance Date

May 22, 2025

Published in Issue

Year 2025 Volume: 10 Number: 2

DOI

https://doi.org/10.31797/vetbio.1619132

IZ

https://izlik.org/JA32RU23SY

Cite

RIS / Bibtex

APA

Havabilen, V., & Erol, M. (2025). Comparison of the effects of Crystalin® spray and Froximun® powder on the healing of open wounds in cats and dogs. Journal of Advances in VetBio Science and Techniques, 10(2), 76-82. https://doi.org/10.31797/vetbio.1619132