Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods

Serpil Aygörmez; Elif Dalkılınç; Nurhan Akaras; Şaban Maraşlı

doi:10.31797/vetbio.1696205

Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods

Abstract

In this study, the protective effect of morin against liver damage caused by Tetracycline (TET) was investigated. Twenty-eight female rats were divided into four groups: control, morin, TET, and TET+morin. TET (140 mg/kg) and morin (100 mg/kg) were administered orally for seven days. Liver enzymes, oxidative stress, and inflammation parameters were analyzed to determine liver tissue damage. In addition, histopathologic analysis was performed to detect tissue damage and structural changes. According to the data obtained from these analyses, TET increased aspartate aminotransferase (AST), alanine aminotransferase (ALT) activities in liver tissue. TET administration increased malondialdehyde (MDA), decreased superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities and glutathione (GSH). Nuclear factor kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), and interleukin 1β (IL-1β) expression levels were found to increase. Administration of morin together with TET decreased AST, ALT activities and MDA, NF-kB, TNF-α, IL-1β levels, and increased CAT, SOD, GSH, GPx. According to the data obtained, TET increases liver enzymes and the increase in these values triggers oxidative stress, and inflammation markers, indicating damage to the liver. Morin's supportive treatment was found to reduce liver damage by bringing these parameters closer to normal.

Keywords

Supporting Institution

No

Project Number

No

Ethical Statement

Ethical approval was obtained from Atatürk University Animal Experiments Local Ethics Committee (Approval No: 2025/01/21).

Thanks

No

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Details

Primary Language

English

Subjects

Veterinary Biochemistry

Journal Section

Research Article

Authors

Serpil Aygörmez ^*
0000-0002-5675-5096
Türkiye

Elif Dalkılınç
0009-0005-1008-111X
Türkiye

Nurhan Akaras
0000-0002-8457-9448
Türkiye

Şaban Maraşlı
0000-0003-0182-6712
Türkiye

Publication Date

December 31, 2025

Submission Date

May 9, 2025

Acceptance Date

September 3, 2025

Published in Issue

Year 2025 Volume: 10 Number: 3

DOI

https://doi.org/10.31797/vetbio.1696205

IZ

https://izlik.org/JA24MJ43EZ

Cite

RIS / Bibtex

APA

Aygörmez, S., Dalkılınç, E., Akaras, N., & Maraşlı, Ş. (2025). Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods. Journal of Advances in VetBio Science and Techniques, 10(3), 153-161. https://doi.org/10.31797/vetbio.1696205

AMA

1.Aygörmez S, Dalkılınç E, Akaras N, Maraşlı Ş. Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods. J Ad VetBio Sci Tech. 2025;10(3):153-161. doi:10.31797/vetbio.1696205

Chicago

Aygörmez, Serpil, Elif Dalkılınç, Nurhan Akaras, and Şaban Maraşlı. 2025. “Effects of Morin Against Tetracycline-Induced Liver Injury in Rats by Biochemical and Histopathological Methods”. Journal of Advances in VetBio Science and Techniques 10 (3): 153-61. https://doi.org/10.31797/vetbio.1696205.

EndNote

Aygörmez S, Dalkılınç E, Akaras N, Maraşlı Ş (December 1, 2025) Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods. Journal of Advances in VetBio Science and Techniques 10 3 153–161.

IEEE

[1]S. Aygörmez, E. Dalkılınç, N. Akaras, and Ş. Maraşlı, “Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods”, J Ad VetBio Sci Tech, vol. 10, no. 3, pp. 153–161, Dec. 2025, doi: 10.31797/vetbio.1696205.

ISNAD

Aygörmez, Serpil - Dalkılınç, Elif - Akaras, Nurhan - Maraşlı, Şaban. “Effects of Morin Against Tetracycline-Induced Liver Injury in Rats by Biochemical and Histopathological Methods”. Journal of Advances in VetBio Science and Techniques 10/3 (December 1, 2025): 153-161. https://doi.org/10.31797/vetbio.1696205.

JAMA

1.Aygörmez S, Dalkılınç E, Akaras N, Maraşlı Ş. Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods. J Ad VetBio Sci Tech. 2025;10:153–161.

MLA

Aygörmez, Serpil, et al. “Effects of Morin Against Tetracycline-Induced Liver Injury in Rats by Biochemical and Histopathological Methods”. Journal of Advances in VetBio Science and Techniques, vol. 10, no. 3, Dec. 2025, pp. 153-61, doi:10.31797/vetbio.1696205.

Vancouver

1.Serpil Aygörmez, Elif Dalkılınç, Nurhan Akaras, Şaban Maraşlı. Effects of morin against tetracycline-induced liver injury in rats by biochemical and histopathological methods. J Ad VetBio Sci Tech. 2025 Dec. 1;10(3):153-61. doi:10.31797/vetbio.1696205

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