Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity

Cemre Aydeğer; Mehmet Akif Ovalı; Mustafa Oguz Cumaoglu; Hilmi Nuhoğlu; Tahir Gezer; Mustafa Makav; Hüseyin Avni Eroğlu

doi:10.31797/vetbio.1786702

Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity

Abstract

Doxorubicin (DOX) is a widely used antineoplastic agent in cancer treatment; however, it has several drawbacks that can cause harmful effects on various organs, especially the kidneys. Nevertheless, it does not fully reveal the extent of DOX-induced tissue damage. Therefore, it is crucial to clarify the risks associated with DOX-mediated tissue injury. A total of 14 female Wistar Albino rats were divided into two equal groups: Control and Dox. The Dox group received a single dose of 20 mg/kg DOX. Kidney, liver, and blood samples were collected for further analysis. Hematoxylin-Eosin staining and biochemical tests were conducted to assess DOX-induced tissue damage. Our results showed that the Dox group experienced significant glomerular atrophy. Parameters such as RBC, HGB, HCT, and MCHC were also significantly higher compared to the Control group. No significant differences were observed in liver tissues between the groups. Inflammatory markers were also evaluated. NLR and SII scores showed statistically significant differences between the groups. Administration of DOX caused alterations in erythrocyte and leukocyte parameters, with notable changes in renal tissue characterized by glomerular atrophy.

Keywords

References

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Details

Primary Language

English

Subjects

Veterinary Anatomy and Physiology, Veterinary Pathology

Journal Section

Research Article

Authors

Cemre Aydeğer
Türkiye

Mehmet Akif Ovalı
0000-0002-3672-871X
Türkiye

Mustafa Oguz Cumaoglu
0000-0003-4245-1101
Türkiye

Hilmi Nuhoğlu
0000-0003-2530-2542
Türkiye

Tahir Gezer
0000-0001-7838-2553
Türkiye

Mustafa Makav
0000-0003-1879-8180
Türkiye

Hüseyin Avni Eroğlu ^*
0000-0002-1040-3255
Türkiye

Publication Date

December 31, 2025

Submission Date

September 18, 2025

Acceptance Date

December 15, 2025

Published in Issue

Year 2025 Volume: 10 Number: 3

DOI

https://doi.org/10.31797/vetbio.1786702

IZ

https://izlik.org/JA35FA37UP

Cite

RIS / Bibtex

APA

Aydeğer, C., Ovalı, M. A., Cumaoglu, M. O., Nuhoğlu, H., Gezer, T., Makav, M., & Eroğlu, H. A. (2025). Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. Journal of Advances in VetBio Science and Techniques, 10(3), 200-204. https://doi.org/10.31797/vetbio.1786702

AMA

1.Aydeğer C, Ovalı MA, Cumaoglu MO, et al. Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. J Ad VetBio Sci Tech. 2025;10(3):200-204. doi:10.31797/vetbio.1786702

Chicago

Aydeğer, Cemre, Mehmet Akif Ovalı, Mustafa Oguz Cumaoglu, et al. 2025. “Hematological Alterations in Erythrogram, Leukogram, and Thrombogram of Rats With Doxorubicin-Induced Renal Toxicity”. Journal of Advances in VetBio Science and Techniques 10 (3): 200-204. https://doi.org/10.31797/vetbio.1786702.

EndNote

Aydeğer C, Ovalı MA, Cumaoglu MO, Nuhoğlu H, Gezer T, Makav M, Eroğlu HA (December 1, 2025) Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. Journal of Advances in VetBio Science and Techniques 10 3 200–204.

IEEE

[1]C. Aydeğer et al., “Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity”, J Ad VetBio Sci Tech, vol. 10, no. 3, pp. 200–204, Dec. 2025, doi: 10.31797/vetbio.1786702.

ISNAD

Aydeğer, Cemre - Ovalı, Mehmet Akif - Cumaoglu, Mustafa Oguz - Nuhoğlu, Hilmi - Gezer, Tahir - Makav, Mustafa - Eroğlu, Hüseyin Avni. “Hematological Alterations in Erythrogram, Leukogram, and Thrombogram of Rats With Doxorubicin-Induced Renal Toxicity”. Journal of Advances in VetBio Science and Techniques 10/3 (December 1, 2025): 200-204. https://doi.org/10.31797/vetbio.1786702.

JAMA

1.Aydeğer C, Ovalı MA, Cumaoglu MO, Nuhoğlu H, Gezer T, Makav M, Eroğlu HA. Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. J Ad VetBio Sci Tech. 2025;10:200–204.

MLA

Aydeğer, Cemre, et al. “Hematological Alterations in Erythrogram, Leukogram, and Thrombogram of Rats With Doxorubicin-Induced Renal Toxicity”. Journal of Advances in VetBio Science and Techniques, vol. 10, no. 3, Dec. 2025, pp. 200-4, doi:10.31797/vetbio.1786702.

Vancouver

1.Cemre Aydeğer, Mehmet Akif Ovalı, Mustafa Oguz Cumaoglu, Hilmi Nuhoğlu, Tahir Gezer, Mustafa Makav, Hüseyin Avni Eroğlu. Hematological alterations in erythrogram, leukogram, and thrombogram of rats with doxorubicin-induced renal toxicity. J Ad VetBio Sci Tech. 2025 Dec. 1;10(3):200-4. doi:10.31797/vetbio.1786702