Protective effects of artichoke (Cynara scolymus L.) extract on ionizing radiation-induced hepatic injury
Abstract
This study investigated the protective effects of artichoke extract (ENG) on ionizing radiation-induced liver damage in rats. Thirty-two 8-week-old male Wistar albino rats were divided into four groups (n=8). The control group received a standard pellet diet for 10 days. The radiation group (RAD) was exposed to 5 Gy single-dose radiation and fed a pellet diet for 10 days. The radiation + artichoke extract group (RAD+ENG) received the same radiation dose and then a pellet diet supplemented with 25 mL/kg ENG for 10 days. The ENG group was fed only a pellet diet enriched with 25 mL/kg ENG for 10 days. At the end of the study, animals were sacrificed, and blood and liver samples were collected. Biochemical assays measured serum and hepatic levels of MDA, GSH, GSH-Px, CAT, and SOD, while serum AST and ALT were also determined. Histopathological evaluations assessed liver lesions, and immunohistochemistry was used to detect Caspase-3 expression. Findings indicated that the RAD group exhibited pronounced hepatic degeneration and necrosis, characterized by significant elevations in MDA, AST, and ALT levels, together with a marked reduction in the antioxidant parameters GSH, GSH-Px, CAT, and SOD. In contrast, ENG administration following radiation reduced AST, ALT, and MDA levels while restoring antioxidant enzyme activities. Histological analysis demonstrated milder lesions in the RAD+ENG group, and immunohistochemistry revealed reduced Caspase-3 expression compared to the RAD group. In conclusion, artichoke extract mitigated ionizing radiation-induced oxidative stress, preserved antioxidant defenses, and provided hepatoprotective effects.
Ethical Statement
Ethical approval for this study was obtained from the Animal Experiments Local Ethics Committee of Yüzüncü Yıl University, (2015/08).
Supporting Institution
This study is part of a research project funded by Research Foundation of Yüzüncü Yıl University Scientific Research Projects Coordination Unit (BAP)
Project Number
2016-VF-B003
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Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Pathology |
| Journal Section | Research Article |
| Authors | |
| Project Number | 2016-VF-B003 |
| Submission Date | September 25, 2025 |
| Acceptance Date | February 2, 2026 |
| Publication Date | February 17, 2026 |
| DOI | https://doi.org/10.31797/vetbio.1790287 |
| IZ | https://izlik.org/JA65NA23JN |
| Published in Issue | Year 2026 Issue: 1 |
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Authors should ensure that they have properly acknowledged the work of others, and should also cite publications that have been influential in determining the nature of the reported work. Authors should not use information obtained in the course of providing confidential services, such as refereeing manuscripts or grant applications unless they have obtained the explicit written permission of the author(s) of the work involved in these services.
Peer review
Authors are obliged to participate in the peer-review process and cooperate fully by responding promptly to the editor’s requests for raw data, clarifications, and proof of ethics approval and copyright permissions.
For Reviewers
Contribution to editorial decisions
Peer review assists editors in making editorial decisions and, through editorial communications with authors may assist authors in improving their manuscripts. Peer review is an essential component of formal scholarly communication and lies at the heart of the scientific endeavor.
Promptness
Any invited a referee who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should immediately notify the editors and decline the invitation to review so that alternative reviewers can be contacted.
Confidentiality
Any manuscripts received for review are confidential documents and must be treated as such; they must not be shown to or discussed with others except if authorized by the Editor-in-Chief (who would only do so under exceptional and specific circumstances). This applies also to invited reviewers who decline the review invitation.
Standards of objectivity
Reviews should be conducted objectively and observations formulated clearly with supporting arguments so that authors can use them for improving the manuscript. Personal criticism of the authors is inappropriate.
Acknowledgment of sources
Reviewers should identify relevant published work that has not been cited by the authors. Any statement that is an observation, derivation or argument that has been reported in previous publications should be accompanied by the relevant citation. A reviewer should also notify the editors of any substantial similarity or the overlap between the manuscript under consideration and any other manuscript (published or unpublished) of which they have personal knowledge.
Disclosure and conflicts of interest
Any invited the referee who has conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies or institutions connected to the manuscript and the work described therein should immediately notify the editors to declare their conflicts of interest and decline the invitation to review so that alternative reviewers can be contacted.
Unpublished material disclosed in a submitted manuscript must not be used in a reviewer’s own research without the express written consent of the authors. Privileged information or ideas obtained through peer review must be kept confidential and not used for the reviewer’s personal advantage. This applies also to invited reviewers who decline the review invitation.
Ethical Responsibilities of Editors
All manuscripts are judged based on the intellectual contents, regardless of gender, race, ethnicity, religion, citizenship or political values of the authors. Personal information related to the articles shall be kept confidential. All identified conflicts of interest of Editorial Board members and the observed conflicts of interest and plagiarism identified in manuscripts and published articles must be disclosed. The Editorial Board shall assume responsibility for making publication decisions for the manuscripts submitted, based on the evaluation of the candidate article, the policies of the editorial board and the copyright infringement rules. A double-blind review system with at least two reviewers is used to evaluate manuscripts for publication.
Editors have the right to reject the manuscripts without peer-review when the manuscript is on a topic outside the scope of the Journal, lacks technical merit, exhibits narrow regional scope and significance presents conflicting results, poorly written, represents a case of scientific misconduct. When the journal is overburdened with too many submissions, editors have the right to reject manuscripts without peer review based on their perceived merit.
Editors are responsible for the final decision regarding the acceptance or rejection of articles.
Rights granted to VetBio Journal
VetBio Journal reserves the right to reject a paper even after it has been accepted if it becomes apparent that there are serious problems with its scientific content, or the publishing policies of the journal have been violated.
Price Policy
The VetBio does not charge submission, processing, or publication fee.
Indexes
Citation Indexes
Other Indexes
Journal Boards
Editor-in-Chief
Associate Editors
1988 Malatya doğumlu. Konya Selçuk Üniversitesi Veteriner Fakültesi 2011 yılı mezunu. 2015 yılında SÜ İç Hastalıkları Anabilim Dalında yüksek lisansını bitirdi. 2020 yılında Kafkas Üniversitesi Veteriner Fakültesi İç Hastalıkları AD dalında doktora eğitimini tamamladı. Kafkas Üniversitesi Veteriner Fakültesinde Doçent Doktor olarak hala görev yapmaktadır.
Language Editor
