Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis

Murat Kaan Durgut; Mahmut Ok; Hatice Betül Şahin; Seyhun Selcen Özvar; Süleyman Serhat İyigün

doi:10.31797/vetbio.1885355

Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis

Abstract

Canine parvoviral enteritis is a viral infection characterized by severe hemorrhagic gastroenteritis, leading to metabolic and electrolyte disturbances and high mortality. The study aimed to evaluate blood gas parameters and the bicarbonate-to-lactate (HCO₃/lactate) ratio for predicting mortality in dogs with parvovirus. The study population consisted of 35 dogs, 25 with parvoviral enteritis and 10 clinically healthy dogs. Venous blood gas analysis, including acid-base parameters, electrolytes, and lactate concentrations, was performed at time of admission. Lactate concentrations were significantly higher in non-survivor (n=12) dogs compared to survivor (n=13) and healthy dogs (p<0.001), while base excess in blood concentrations were lower (p=0.018). Additionally, the HCO₃/lactate ratio was significantly lower in non-survivor dogs compared to survivors. In dogs with parvoviral enteritis, pCO2, sodium and chloride levels were significantly lower compared to the healthy group (p<0.05). Receiver operating characteristic (ROC) analysis revealed cut-off values of 6.03 for the HCO₃/lactate ratio (area under the curve [AUC]: 0.763, p = 0.014) and 3.29 mmol/L for lactate (AUC: 0.776, p = 0.009) for predicting mortality. In conclusion, the HCO₃/lactate ratio is a valuable prognostic marker reflecting the metabolic acidosis and poor tissue perfusion. This ratio is a useful parameter in clinical practice and can be evaluated together with individual blood gas parameters to improve mortality prediction.

Keywords

References

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Details

Primary Language

English

Subjects

Veterinary Internal Medicine

Journal Section

Research Article

Authors

Murat Kaan Durgut ^*
0000-0002-4582-8536
Türkiye

Mahmut Ok
0000-0002-8210-6735
Türkiye

Hatice Betül Şahin
0000-0002-5341-9468
Türkiye

Seyhun Selcen Özvar
0009-0004-6784-0570
Türkiye

Süleyman Serhat İyigün
0000-0002-3270-1931
Türkiye

Publication Date

May 7, 2026

Submission Date

February 9, 2026

Acceptance Date

May 6, 2026

Published in Issue

Year 2026 Number: 2

DOI

https://doi.org/10.31797/vetbio.1885355

IZ

https://izlik.org/JA84BY47MW

Cite

RIS / Bibtex

APA

Durgut, M. K., Ok, M., Şahin, H. B., Özvar, S. S., & İyigün, S. S. (2026). Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. Journal of Advances in VetBio Science and Techniques, 2, 115-120. https://doi.org/10.31797/vetbio.1885355

AMA

1.Durgut MK, Ok M, Şahin HB, Özvar SS, İyigün SS. Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. J Ad VetBio Sci Tech. 2026;(2):115-120. doi:10.31797/vetbio.1885355

Chicago

Durgut, Murat Kaan, Mahmut Ok, Hatice Betül Şahin, Seyhun Selcen Özvar, and Süleyman Serhat İyigün. 2026. “Evaluation of Blood Gas Parameters and the Bicarbonate-to-Lactate Ratio for Mortality Prediction in Dogs With Parvoviral Enteritis”. Journal of Advances in VetBio Science and Techniques, nos. 2: 115-20. https://doi.org/10.31797/vetbio.1885355.

EndNote

Durgut MK, Ok M, Şahin HB, Özvar SS, İyigün SS (May 1, 2026) Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. Journal of Advances in VetBio Science and Techniques 2 115–120.

IEEE

[1]M. K. Durgut, M. Ok, H. B. Şahin, S. S. Özvar, and S. S. İyigün, “Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis”, J Ad VetBio Sci Tech, no. 2, pp. 115–120, May 2026, doi: 10.31797/vetbio.1885355.

ISNAD

Durgut, Murat Kaan - Ok, Mahmut - Şahin, Hatice Betül - Özvar, Seyhun Selcen - İyigün, Süleyman Serhat. “Evaluation of Blood Gas Parameters and the Bicarbonate-to-Lactate Ratio for Mortality Prediction in Dogs With Parvoviral Enteritis”. Journal of Advances in VetBio Science and Techniques. 2 (May 1, 2026): 115-120. https://doi.org/10.31797/vetbio.1885355.

JAMA

1.Durgut MK, Ok M, Şahin HB, Özvar SS, İyigün SS. Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. J Ad VetBio Sci Tech. 2026;:115–120.

MLA

Durgut, Murat Kaan, et al. “Evaluation of Blood Gas Parameters and the Bicarbonate-to-Lactate Ratio for Mortality Prediction in Dogs With Parvoviral Enteritis”. Journal of Advances in VetBio Science and Techniques, no. 2, May 2026, pp. 115-20, doi:10.31797/vetbio.1885355.

Vancouver

1.Murat Kaan Durgut, Mahmut Ok, Hatice Betül Şahin, Seyhun Selcen Özvar, Süleyman Serhat İyigün. Evaluation of blood gas parameters and the bicarbonate-to-lactate ratio for mortality prediction in dogs with parvoviral enteritis. J Ad VetBio Sci Tech. 2026 May 1;(2):115-20. doi:10.31797/vetbio.1885355