Should pimobendan always be used in congenital heart failure in dog and cats?

Abstract

Pimobendan has a positive inotropic and vasodilatory effect by sensitization of calcium and inhibiton of phosphodiesterase III enzyme. It is widely used for treatment of congestive heart failure from chronic valvular disease or dilated cardiomyopathy both human and veterinary medicine. Positive findings have advised about pimobendan association with increasing life quality, reducing heart failure score and increasing survival time, however, potential side effects also available. Studies of pimobendan uses in cats are underway to further assess. Therefore, it can be suggested that safe use of pimobendan is not inconvenient unless it is used except in indications.

Keywords

• Pimobendan,Cat,Dog,Congestive heart failure

Köpek ve kedilerde konjestif kalp yetmezliklerinde her daim pimobendan kullanılmalı mı?

Abstract

Pimobendan pozitif inotropik ve vazodilatatör etkilerini kalsiyuma karşı duyarlılığı arttırarak ve fosfodiesteraz III enzim inhibisyonu ile gerçekleştirmektedir. Hem beşeri hem de veteriner hekimliği alanında kronik kapakçık yetmezliği ve dilate kardiyomiyopatiden kaynaklanan konjestif kalp hastalıklarının tedavisinde yaygın olarak kullanılmaktadır. Yaşam kalitesini arttırma, kalp yetmezliği skorlamasında azalma ve yaşam süresini uzatma ile ilişkili pozitif bulgularından bahsedilirken potansiyel yan etkileri de bulunmaktadır. Kedilerde pimobendan kullanımına yönelik araştırmalar halen devam etmektedir. Sonuç olarak endike olduğu durumlar dışında kullanılmadığı sürece, pimobendanın güvenle kullanılmasının sakıncalı olmadığı öne sürülebilir.

Keywords

• Pimobendan,Kedi,Köpek,Konjestif kalp yetmezliği

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