Efficacy of intravenous phenylbutazone for pain management in dogs undergoing ovariohysterectomy

Abstract

The aim of the present study was to evaluate the efficacy and analgesic duration of single dose of PBZ administered the IV route immediately before induction of anesthesia in dogs undergoing elective OVH. Eight-teeen sexually intact female dogs (weiging between 4.5 and 28 kg, and 1 to 8 yrs of age) referred for OVH procedure from a local shelter at regular intervals over 4 months were included in the study. The dogs were administered PBZ on the basis of their respective treatment group (20 mg/kg, IV administration) immediately before anesthetic induction. For the IV treatment, PBZ was administered over a period of one minute. Time of completion of PBZ administration was designed as time 0. In control group, 0.9% NaCl was administered IV as over a period of one minute. Throughout the study, pre and postoperative pain was assessed at baseline (before induction of anesthesia) and then at 0.5, 1, 2, 3, 8, and 24 hrs after the surgery. Group IV had significantly lower CMPS-SF scores than the control group at the 0.5, 1, 2, 3, and 8 hour postoperative periods. In conclusion, a single dose of PBZ administered via the IV route before surgery may be particularly beneficial for acheiving reasonable perioperative analgesia, but not in postoperative period. 

Keywords

• Ovariyohisterektomi,Ağrı,Fenilbutazon

References

1. Carpenter, S.L., Mcdonnell, W.M. (1995). Misuse of veterinary phenylbutazone. Arch Intern Med, 155: 1229–1231.
2. Grandemange, E., Fournel, S., Woehrlé, F. (2013). Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. J Small Anim Pract, 54: 304–312.
3. Gruet, P., Seewald, W., King, N.J. (2013). Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial. BMC Vet Res, 9: 92.
4. Hunt, J.R., Grint, N.J., Taylor, P.M., et al. (2013). Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs. Vet Anaesth Analg, 40: 297-307.
5. Ko, J.C., Freeman, L.J., Barletta, M., et al. (2011). Efficacy of oral transmucosal and intravenous administration of buprenorphine before surgery for postoperative analgesia in dogs undergoing ovariohysterectomy. J Am Vet Med Assoc, 238: 318–328.
6. Lees, P., Landoni, M.F., Giraudel, J., et al. (2004). Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest. J Vet Pharm Therap, 27: 479–490.
7. Marcovich, R., Williams, A.L., Seifman, B.D., et al. (2001). A canine model to assess the biochemical stress response to laparoscopic and open surgery. J Endourol, 15: 1005-1008.
8. Mbugua, S.W., Skoglund, L.A., Løkken, P. (1989). Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs. Acta Vet Scand, 30: 27-35.

9. Mills, P.C., Ng, J.C., Skelton, K.V., et al. (1995). Phenylbutazone in racing greyhounds: plasma and urinary residues 24 and 48 hours after a single intravenous administration. Aust Vet J, 72: 304-8.
10. Ortega, M. and Cruz, I. (2011). Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery. Can Vet J, 52: 856-860.
11. Pacheco, P.F., Galeazzi, V.S., Patrício, G.C.F., et al. (2018). Anesthetic complications in diabetic dogs subjected to phacoemulsification. Pesq Vet Bras, 38: 1423-1430.
12. Peers, A., Mellor, D.J., Wintour, E.M., et al. (2002). Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs. N Z Vet J, 50: 56-62.
13. Reid, J., Nolan, A.M., Hughes, J.M.L., et al. (2007). Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Anim Welf, 16: 97-104.
14. Thurman, J.C., Tanquilli, W.J., Benson, G.J. (1996). Preanesthetics and anesthetic adjuncts. In: Thurmon JC, Tranquilli WC, Benson GJ eds. Lumb and Jones Veterinary Anesthesia. 3rd ed. Philadelphia: Williams and Wilkins, 183-203.
15. Williamson, H.E., Gaffney, G.R., Bourland, W.A., et al. (1978). Phenylbutazone-induced decrease in renal blood flow. J Pharmacol Exp Ther, 204: 130-134.
16. Zech, R., Scherkl, R., Hashem, A., Frey, H.H. (1993). Plasma and tissue kinetics of phenylbutazone and naproxen in dogs. Arch Int Pharmacodyn Ther, 325: 113-128.