Should pimobendan always be used in congenital heart failure in dog and cats?

Yıl 2017, Cilt: 2 Sayı: 2, 24 - 29, 31.08.2017

Songül Toplu Kerem Ural Sezen Doğan

https://doi.org/10.31797/vetbio.306560

Öz

Pimobendan
has a positive inotropic and vasodilatory effect by sensitization of calcium
and inhibiton of phosphodiesterase III enzyme. It is widely used for treatment
of congestive heart failure from chronic valvular disease or dilated
cardiomyopathy both human and veterinary medicine. Positive findings have advised
about pimobendan association with increasing life quality, reducing heart
failure score and increasing survival time, however, potential side effects
also available. Studies of pimobendan uses in cats are underway to further assess.
Therefore, it can be suggested that safe use of pimobendan is not inconvenient
unless it is used except in indications.

Anahtar Kelimeler

Pimobendan, Cat, Dog, Congestive heart failure

Köpek ve kedilerde konjestif kalp yetmezliklerinde her daim pimobendan kullanılmalı mı?

Öz

Pimobendan pozitif inotropik
ve vazodilatatör etkilerini kalsiyuma karşı duyarlılığı arttırarak ve
fosfodiesteraz III enzim inhibisyonu ile gerçekleştirmektedir. Hem beşeri hem
de veteriner hekimliği alanında kronik kapakçık yetmezliği ve dilate kardiyomiyopatiden
kaynaklanan konjestif kalp hastalıklarının tedavisinde yaygın olarak kullanılmaktadır.
Yaşam kalitesini arttırma, kalp yetmezliği skorlamasında azalma ve yaşam
süresini uzatma ile ilişkili pozitif bulgularından bahsedilirken potansiyel yan
etkileri de bulunmaktadır. Kedilerde pimobendan kullanımına yönelik araştırmalar
halen devam etmektedir. Sonuç
olarak endike olduğu durumlar dışında kullanılmadığı sürece, pimobendanın
güvenle kullanılmasının sakıncalı olmadığı öne sürülebilir.

Anahtar Kelimeler

Pimobendan, Kedi, Köpek, Konjestif kalp yetmezliği

Kaynakça

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