Intra and postoperative effectives of oral transmucosal administration of phenylbutazone for pain managament in dogs

Year 2019, Volume: 4 Issue: 3, 90 - 97, 30.12.2019

Murat Kibar

https://doi.org/10.31797/vetbio.599720

Abstract

The aim of the
present study was to evaluate the efficacy and analgesic duration of single
dose of phenylbutazone administered by oral transmukosal route immediately
before induction of anesthesia in dogs undergoing elective ovariohysterectomy.
Eight-teen sexually intact female dogs (weiging between 5 and 30 kg, and 1 to 7
yrs of age) referred for ovariohysterectomy procedure from a local shelter at
regular intervals over 3 months were included in the study. The dogs were
administered phenylbutazone on the basis of their respective treatment group
(20 mg/kg via oral transmucosal administration) immediately before anesthetic
induction. The syringe was placed in the cheek pouch of the dog, and
phenylbutazone was slowly administered over a period of 1 to 3 minutes to
ensure the drug did not drip out of the dog’s mouth, or was not swallowed by
the dog. In control group, 0.9% NaCl was administered in the cheek pouch of the
dog. Throughout the study, pre and postoperative pain was assessed at baseline
(before induction of anesthesia) and then at 0.5, 1, 2, 3, 8, and 24 hrs after the
surgery. Group
oral transmucosal had significantly lower Glascow pain scores than the control
group at the 0.5, 1, 2, 3, and 8 hour postoperative periods. In conclusion, a
single dose of phenylbutazone administered via the oral transmucosal route
before surgery may be particularly beneficial for acheiving reasonable
perioperative analgesia, but not in postoperative period.

Keywords

Ovariohysterectomy, Pain, Phenylbutazone

Supporting Institution

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Project Number

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Thanks

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References

• Carpenter, S.L., Mcdonnell, W.M. (1995). Misuse of veterinary phenylbutazone. Arch Intern Med, 155: 1229–1231.
• Grandemange, E., Fournel, S., Woehrlé, F. (2013). Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. J Small Anim Pract, 54: 304–312.
• Gruet, P., Seewald, W., King, N.J. (2013). Robenacoxib versus meloxicam for the management of pain and inflammation associated with soft tissue surgery in dogs: a randomized, non-inferiority clinical trial. BMC Vet Res, 9: 92.
• Hunt, J.R., Grint, N.J., Taylor, P.M., et al. (2013). Sedative and analgesic effects of buprenorphine, combined with either acepromazine or dexmedetomidine, for premedication prior to elective surgery in cats and dogs. Vet Anaesth Analg, 40: 297-307.
• Jackson, M.L., Searcy, G.P., Olexson, D.W. (1985). The effect of oral phenylbutazone on whole blood platelet aggregation in the dog. Can J Comp Med, 49: 271-277.
• Ko, J.C., Freeman, L.J., Barletta, M., et al. (2011). Efficacy of oral transmucosal and intravenous administration of buprenorphine before surgery for postoperative analgesia in dogs undergoing ovariohysterectomy. J Am Vet Med Assoc, 238: 318–328. Lees, P., Landoni, M.F., Giraudel, J., et al. (2004). Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest. J Vet Pharm Therap, 27: 479–490.
• Marcovich, R., Williams, A.L., Seifman, B.D., et al. (2001). A canine model to assess the biochemical stress response to laparoscopic and open surgery. J Endourol, 15: 1005-1008.
• Mbugua, S.W., Skoglund, L.A., Løkken, P. (1989). Effects of phenylbutazone and indomethacin on the post-operative course following experimental orthopaedic surgery in dogs. Acta Vet Scand, 30: 27-35.
• Mills, P.C., Ng, J.C., Skelton, K.V., et al. (1995). Phenylbutazone in racing greyhounds: plasma and urinary residues 24 and 48 hours after a single intravenous administration. Aust Vet J, 72: 304-8.
• Ortega, M. and Cruz, I. (2011). Evaluation of a constant rate infusion of lidocaine for balanced anesthesia in dogs undergoing surgery. Can Vet J, 52: 856-860.
• Pacheco, P.F., Galeazzi, V.S., Patrício, G.C.F., et al. (2018). Anesthetic complications in diabetic dogs subjected to phacoemulsification. Pesq Vet Bras, 38: 1423-1430.
• Peers, A., Mellor, D.J., Wintour, E.M., et al. (2002). Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs. N Z Vet J, 50: 56-62.
• Reid, J., Nolan, A.M., Hughes, J.M.L., et al. (2007). Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score. Anim Welf, 16: 97-104.
• Thurman, J.C., Tanquilli, W.J., Benson, G.J. (1996). Preanesthetics and anesthetic adjuncts. In: Thurmon JC, Tranquilli WC, Benson GJ eds. Lumb and Jones Veterinary Anesthesia. 3rd ed. Philadelphia: Williams and Wilkins, 183-203.
• Williamson, H.E., Gaffney, G.R., Bourland, W.A., et al. (1978). Phenylbutazone-induced decrease in renal blood flow. J Pharmacol Exp Ther, 204: 130-134.
• Zech, R., Scherkl, R., Hashem, A., Frey, H.H. (1993). Plasma and tissue kinetics of phenylbutazone and naproxen in dogs. Arch Int Pharmacodyn Ther, 325: 113-128.