Investigation of correlation between corneal thickness and intraocular pressure in New Zealand Albino Rabbits

Year 2022, Volume: 7 Issue: 1, 54 - 61, 30.04.2022

Büşra Kibar Kurt

https://doi.org/10.31797/vetbio.980971

Cited By: 2

Abstract

The aim of this study was to determine intraocular pressure (IOP) and central corneal thickness (CCT) measurements in healthy rabbits to establish clinical reference values and to investigate the possible relationship between these measurements. The study included 40 eyes of 20 New Zealand albino rabbits, aged 1.5-2 years. All the eyes were healthy with no abnormalities, corneal disease, or evidence of glaucoma. An ultrasonographic pachymeter was used to measure CCT and TonoVet® was used to measure IOP. Correlations between IOP and CCT measurements were examined. The mean CCT was 388.2 ± 38.22 µm in the right eye and 391.8± 59.18 µm in the left eye. IOP was measured as 16 ± 3.76 mmHg in the right eye and 16 ± 2.73 mmHg in the left eye. No correlation was determined between the IOP and CCT, and this indicated that the TonoVet® readings of CCT and IOP did not cause a deviation that could be determined. There is a need for further studies of different animals to investigate the effect of corneal thickness on the IOP measurements made with TonoVet®.

Keywords

central corneal thickness, intraocular pressure, pachymeter, rebound tonometer

References

• A. Bouhenni, R., Dunmire, J., Sewell, A., & Edward, D. P. (2012). Animal Models of Glaucoma. Journal of Biomedicine and Biotechnology, 2012, 1–11. https://doi.org/10.1155/2012/692609
• Abrams, L. S., Vitale, S., & Jampel, H. D. (1996). Comparison of three tonometers for measuring intraocular pressure in rabbits. Investigative Ophthalmology & Visual Science, 37(5), 940–944. http://www.ncbi.nlm.nih.gov/pubmed/8603880
• Acosta, A. C., Espana, E. M., Nose, I., Orozco, M., Yamamoto, H., Venkatraman, A. S., Fantes, F., & Parel, J.-M. (2007). Estimation of Intraocular Pressure in Rabbits With Commonly Used Tonometers. Ophthalmic Surgery, Lasers and Imaging Retina, 38(1), 43–49. https://doi.org/10.3928/15428877-20070101-06
• Becker, B. (1960). Hypothermia and aqueous humor dynamics of the rabbit eye. Transactions of the American Ophthalmological Society, 58, 337–363. http://www.ncbi.nlm.nih.gov/pubmed/13688428
• Behar-Cohen, F. F., Goureau, O., D’Hermies, F., & Courtois, Y. (1996). Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Investigative Ophthalmology & Visual Science, 37(8), 1711–1715. http://www.ncbi.nlm.nih.gov/pubmed/8675417
• Belovay, G. W., & Goldberg, I. (2018). The thick and thin of the central corneal thickness in glaucoma. Eye, 32(5), 915–923. https://doi.org/10.1038/s41433-018-0033-3
• Brandt, J. D., Beiser, J. A., Gordon, M. O., & Kass, M. A. (2004). Central corneal thickness and measured IOP response to topical ocular hypotensive medication in the Ocular Hypertension Treatment Study. American Journal of Ophthalmology, 138(5), 717–722. https://doi.org/10.1016/j.ajo.2004.07.036
• Brown, K. E., & Congdon, N. G. (2006). Corneal structure and biomechanics: Impact on the diagnosis and management of glaucoma. Current Opinion in Ophthalmology, 17(4), 338–343. https://doi.org/10.1097/01.icu.0000233951.01971.5b
• Chan, T., Payor, S., & Holden, B. A. (1983). Corneal thickness profiles in rabbits using an ultrasonic pachometer. Investigative Ophthalmology & Visual Science, 24(10), 1408–1410. http://www.ncbi.nlm.nih.gov/pubmed/6618800
• Chan, Toiloi, Payor, S., & Holden, B. a. (1983). Corned Thickness Profiles in Robbits Using on Ultrosonic Pochometer. Investigative Ophthalmology and Visual Sciences, 24, 1408–1410.
• Charisis, S. K., Ginis, H. S., Kounis, G. A., & Tsilimbaris, M. K. (2008). Tono-Pen XL tonometry during application of a suction ring in rabbits. BMC Ophthalmology, 8(1), 14. https://doi.org/10.1186/1471-2415-8-14
• Doğan, Z., & Kibar, M. (2015). Tavşanlarda Bazı Antiglokomatöz İlaçların Göz İçi Basıncı Üzerine Etkileri*. Erciyes Üniversitesi Veteriner Fakültesi Dergisi, 12(2), 99–107.
• Garway-Heath, D. F., Crabb, D. P., Bunce, C., Lascaratos, G., Amalfitano, F., Anand, N., Azuara-Blanco, A., Bourne, R. R., Broadway, D. C., Cunliffe, I. A., Diamond, J. P., Fraser, S. G., Ho, T. A., Martin, K. R., McNaught, A. I., Negi, A., Patel, K., Russell, R. A., Shah, A., … Zeyen, T. G. (2015). Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. The Lancet, 385(9975), 1295–1304. https://doi.org/10.1016/S0140-6736(14)62111-5
• Gelatt, K. N., & MacKay, E. O. (2004a). Prevalence of the breed-related glaucomas in pure-bred dogs in North America. Veterinary Ophthalmology, 7(2), 97–111. https://doi.org/10.1111/j.1463-5224.2004.04006.x
• Gelatt, K. N., & MacKay, E. O. (2004b). Secondary glaucomas in the dog in North America. Veterinary Ophthalmology, 7(4), 245–259. https://doi.org/10.1111/j.1463-5224.2004.04034.x
• Gerometta, R., Alvarez, L. J., & Candia, O. A. (2012). Sildenafil Accelerates Anterior Chamber Refilling after Paracentesis in Sheep and Rabbits. Investigative Opthalmology & Visual Science, 53(2), 565. https://doi.org/10.1167/iovs.11-8275
• Gloe, S., Rothering, A., Kiland, J. A., & McLellan, G. J. (2019). Validation of the Icare® TONOVET plus rebound tonometer in normal rabbit eyes. Experimental Eye Research, 185(June), 107698. https://doi.org/10.1016/j.exer.2019.107698
• Gupta, S. K., Saxena, R., Agarwal, R., Galpalli, N. D., Srivastava, S., & Agrawal, S. S. (2007). Estimation of intraocular pressure in rabbits using Non Contact Tonometer: A comparative evaluation with Schiotz Tonometer. Methods and Findings in Experimental and Clinical Pharmacology, 29(6), 405. https://doi.org/10.1358/mf.2007.29.6.1119161
• Herse, P., & Yao, W. (2009). Variation of corneal thickness with age in young New Zealanders. Acta Ophthalmologica, 71(3), 360–364. https://doi.org/10.1111/j.1755-3768.1993.tb07148.x
• Ito, Y., Nagai, N., Okamoto, N., Shimomura, Y., Nakanishi, K., & Tanaka, R. (2013). Reduction of Enhanced Rabbit Intraocular Pressure by Instillation of Pyroglutamic Acid Eye Drops. Biological and Pharmaceutical Bulletin, 36(6), 1017–1023. https://doi.org/10.1248/bpb.b13-00159
• Jin, J., Xu, G., & Yuan, Z. (2014). Influence of the Hypothalamic Arcuate Nucleus on Intraocular Pressure and the Role of Opioid Peptides. PLoS ONE, 9(4), e82315. https://doi.org/10.1371/journal.pone.0082315
• Kass, M. A., Podos, S. M., Moses, R. A., & Becker, B. (1972). Prostaglandin E 1 and aqueous humor dynamics. Investigative Ophthalmology, 11(12), 1022–1027. http://www.ncbi.nlm.nih.gov/pubmed/4638977
• Khan, M. A. (2019). Distribution and measurement of corneal thickness in rabbits. Investigative Ophthalmology & Visual Science, 6805. https://iovs.arvojournals.org/article.aspx?articleid=2746137
• Li, H. F., Petroll, W. M., Møller-Pedersen, T., Maurer, J. K., Cavanagh, H. D., & Jester, J. V. (1997). Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF). Current Eye Research, 16(3), 214–221. https://doi.org/10.1076/ceyr.16.3.214.15412
• Li, J. (2004). Clinical Comparison of the Proview Eye Pressure Monitor With the GoldmannApplanation Tonometer and the TonoPen. Archives of Ophthalmology, 122(8), 1117. https://doi.org/10.1001/archopht.122.8.1117
• Lim, K. S., Wickremasinghe, S. S., Cordeiro, M. F., Bunce, C., & Khaw, P. T. (2005a). Accuracy of intraocular pressure measurements in New Zealand white rabbits. Investigative Ophthalmology and Visual Science, 46(7), 2419–2423. https://doi.org/10.1167/iovs.04-0610
• Lim, K. S., Wickremasinghe, S. S., Cordeiro, M. F., Bunce, C., & Khaw, P. T. (2005b). Accuracy of Intraocular Pressure Measurements in New Zealand White Rabbits. Investigative Opthalmology & Visual Science, 46(7), 2419. https://doi.org/10.1167/iovs.04-0610
• Ma, D., Chen, C.-B., Liang, J., Lu, Z., Chen, H., & Zhang, M. (2016). Repeatability, reproducibility and agreement of intraocular pressure measurement in rabbits by the TonoVet and Tono-Pen. Scientific Reports, 6(1), 35187. https://doi.org/10.1038/srep35187
• Mansoori, T., & Balakrishna, N. (2018). Effect of central corneal thickness on intraocular pressure and comparison of Topcon CT‐80 non‐contact tonometry with Goldmann applanation tonometry. Clinical and Experimental Optometry, 101(2), 206–212. https://doi.org/10.1111/cxo.12620
• Mermoud, A., Baerveldf, G., Minckler, D. S., Lee, M. B., & Rao, N. A. (1995). Measurement of Rabbit Intraocular Pressure with the Tono-Pen. Ophthalmologica, 209(5), 275–277. https://doi.org/10.1159/000310630
• Millar, J. C., & Pang, I. H. (2014). Non-continuous measurement of intraocular pressure in laboratory animals. Experimental Eye Research, 141, 74–90. https://doi.org/10.1016/j.exer.2015.04.018
• Nejabat, M., Heidary, F., Talebnejad, M. R., Salouti, R., Nowroozzadeh, M. H., Masoumpour, M., Mahdaviazad, H., Tajbakhsh, Z., Keshtkar, M., Jamali, H., Khalili, M. R., Movahedan, H., Roustaei, N., & Gharebaghi, R. (2016). Correlation Between Intraocular Pressure and Central Corneal Thickness in Persian Children. Ophthalmology and Therapy, 5(2), 235–243. https://doi.org/10.1007/s40123-016-0063-5
• Ozbek, Z., Cohen, E. J., Hammersmith, K. M., & Rapuano, C. J. (2006). Dynamic Contour Tonometry. Cornea, 25(8), 890–894. https://doi.org/10.1097/01.ico.0000224649.12214.33
• Pereira, F. Q., Bercht, B. S., Soares, M. G., da Mota, M. G. B., & Pigatto, J. A. T. (2011). Comparison of a rebound and an applanation tonometer for measuring intraocular pressure in normal rabbits. Veterinary Ophthalmology, 14(5), 321–326. https://doi.org/10.1111/j.1463-5224.2011.00879.x
• Pigatto, J. A. T., Pereira, F. Q., Albuquerque, L., Corrêa, L. F. D., Bercht, B. S., Hünning, P. S., Silva, A. A. R., & Freitas, L. V. R. P. de. (2011). Intraocular pressure measurement in sheep using an applanation tonometer. Revista Ceres, 58(6), 685–689. https://doi.org/10.1590/S0034-737X2011000600002
• Schulz, D., Iliev, M. E., Frueh, B. E., & Goldblum, D. (2003). In vivo pachymetry in normal eyes of rats, mice and rabbits with the optical low coherence reflectometer. Vision Research, 43(6), 723–728. https://doi.org/10.1016/S0042-6989(03)00005-1
• Tham, Y.-C., Li, X., Wong, T. Y., Quigley, H. A., Aung, T., & Cheng, C.-Y. (2014). Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040. Ophthalmology, 121(11), 2081–2090. https://doi.org/10.1016/j.ophtha.2014.05.013
• Wang, X., Dong, J., & Wu, Q. (2013). Twenty-four-hour measurement of IOP in rabbits using rebound tonometer. Veterinary Ophthalmology, 16(6), 423–428. https://doi.org/10.1111/vop.12020
• Wang, X., & Wu, Q. (2013). Normal corneal thickness measurements in pigmented rabbits using spectral-domain anterior segment optical coherence tomography. Veterinary Ophthalmology, 16(2), 130–134. https://doi.org/10.1111/j.1463-5224.2012.01041.x
• Williams, D. L. (2012). Ophthalmology of Exotic Pets. In Ophthalmology of Exotic Pets. John Wiley & Sons, Ltd. https://doi.org/10.1002/9781118709627 Wind, C. A., & Irvine, A. R. (1969). Electronic applanation tonometry in corneal edema and keratoplasty. Investigative Ophthalmology, 8(6), 620–624. http://www.ncbi.nlm.nih.gov/pubmed/4902381
• Zhang, H., Yang, D., Ross, C. M., Wigg, J. P., Pandav, S., & Crowston, J. G. (2014). Validation of rebound tonometry for intraocular pressure measurement in the rabbit. Experimental Eye Research, 121, 86–93. https://doi.org/10.1016/j.exer.2014.02.004