Araştırma Makalesi
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Clinical and immunohistochemical evaluation of penile tumors in bulls

Yıl 2022, Cilt: 7 Sayı: 2, 210 - 219, 31.08.2022
https://doi.org/10.31797/vetbio.1086702

Öz

Fibropapilloma is the most common neoplasic formation associated with bovine papillomavirus type I. It occurs inside the penis of bulls and causes clinically adverse effects, such as phimosis, paraphimosis, urethral stricture, and urinary retention. This study aimed to conduct a clinical and immunohistochemical evaluation of penile tumors, which are associated with adverse outcomes with regard to breeding value and yield in bulls.A total of 40 bulls of different breeds aged between 10 months to 3 years were included in the study. Tumor tissue samples collected postoperatively were fixed in 10% buffered formaldehyde solution. The avidin–biotin–peroxidase method was used for immunohistochemical staining. Three separate areas were examined under 40X objective lens for each fibropapilloma tissue. The immunoreactivity was classified as none (-), mild (+), moderate (++), and severe (+++). Fibropapillomas ranged from 2 to 10 cm in diameter. Thirty-two papillomas were pedunculated and eight were sessile and attached to the body; 30 were solitary and 10 were multiple. There were 13 relapsed cases and 27 non-relapsed cases. Immunohistochemical examination revealed a statistically significant difference in the binary comparisons of proliferating cell nuclear antigen (PCNA) and hypoxanthine-guanine phosphoribosyltransferase (HPRT) based on positive cell scoring between the relapsed and non-relapsed cases. As a result, it was concluded that the clinical data together with the cancer markers, which were used in the immunohistochemical evaluation and were of great importance in terms of the prognosis of penile tumors that caused significant economic losses, are useful parameters in evaluating the malignancy of penile tumors.

Teşekkür

Thanks: For his support, Assoc. Dr. We would like to thank Mushap KURU.

Kaynakça

  • Beytut, E. (2017). Pathological and immunohistochemical evaluation of skin and teat papillomas in cattle. Turkish Journal Veterinary Animal Science, 41 (2), 204-12.
  • Biricik, H.S., Çimtay, İ., Keskin, O., & Baba, Z.F. (2002). Bir Boğada Gözlenen Penis Fibropapillomunun Sağaltımında Otolog Aşı ve Otohemoterapi Kombinasyonunun Etkisi. Veteriner Hekimleri Mikrobiyoloji Dergisi, 2(2);13-6.
  • Bulut. S., & Ünsaldı, S. (2001). Sığırlarda Gözlenen Penis Fibropapillomlarının Operatif Sağaltımı. Fırat Üniversitesi Sağlık Bilimleri Dergisi, 15(1):139-144.
  • Hatipoğlu, F., Özdemir, O., & Kıran, M.M. (2009). Detection of argyrophil nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in epithelial skin tumours from domestic animals. Revue Médicina Véterinaria, 160(10): 477-83.
  • Heppelman, M., Strüve, K., Hansmann, F., Seehusen, F., & Kehler, W. (2019). Urethral fistula after resection of a penile fibropapilloma in a Holstein Friesian bull. Schweizer Archiv Fur Tierheilkunde, 161; 553-557.
  • Sedano, M., Ramos, E., Choudhari, R., Harrison, A., Subramani, R., Lakshmanaswamy, R., Zilaie, M., & Gadad, S.S. (2020). Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast Cancer. Cancers (Basel), 12 (6): 1522.
  • Jelínek, F., & Tachezy, R. (2005). Cutaneous papillomatosis in cattle. Journal of Comparative Pathology, 132(1):70-81.
  • Kamiloğlu, A., Öztürk, S., Kılıç, E., & Aksoy, Ö. (2004). Boğalarda Penis, Prepisyum Hastalıkları ve Sağaltım Olanakları: 150 Olgu (2000-2003). Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 10(1):31-36.
  • Kaya, M., Okumuş, Z., Doğan, E., Yanmaz, L.E., & Çetin, E.M. (2010). Boğalarda Penis ve Preputium Hastalıklarının Değerlendirilmesi. Fırat Üniversitesi Sağlık Bilimleri Dergisi,24 (3): 149 – 156.
  • Kelman, Z. (1997). PCNA structure, functions and interactions. Oncogene 14:629–640.
  • Khodakaram, T.A., & Kargar, M. (2009). Gross and histopathologic characteristics of penile fibropapillomas in young bulls. Comparative Clinical Pathology, 18:261–263.
  • Maeda, Y., Shibahara, T., Wada, Y., Kadota, K., Kanno, T., Uchida, I., & Hatama, S. (2007). An outbreak of teat papillomatosis in cattle caused by bovine papilloma virus (BPV) type 6 and unclassified BPVs. Veterinary Microbiology, 121:242-248.
  • Maga, G., & Hübscher, U. (2003). Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Journal of Cell Science, 116:3051-60.
  • Özsoy, Ş.Y., Özyıldız, Z., & Güzel, M. (2011). Clinical, pathological and immuno-histochemical findings of bovine cutaneous papillomatosis. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 58: 161-5.
  • Townsend, M.H., Anderson, M.D., Weagel, E.G., Velazquez, E.J., Weber, K.S., Robison, R.A., & O'Neill, K.L. (2017). Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane. OncoTargets and Therapy. 10:1921-32.
  • Townsend, M.H., Bennion, K.B., Bitter, E.E., Felsted, A.M., Robison, R.A., & O'Neill, K.L. (2021). Overexpression and surface localization of HPRT in prostate cancer provides a potential target for cancer specific antibody mediated cellular cytotoxicity. Experimental Cell Research. 403 (1):112567.
  • Townsend, M.H., Felsted, A.M., Burrup, W., Robison, R.A., & O'Neill, K.L. (2018a). Examination of Hypoxanthine Guanine Phosphoribosyltransferase as a biomarker for colorectal cancer patients. Molecular & Cellular Oncology, 5(4):e1481810.
  • Townsend, M.H., Felsted, A.M., Ence, Z.E., Piccolo, S.R., Robison, R.A., & O’Neill, K.L. (2019). Falling from grace: HPRT is not suitable as an endogenous control for cancer-related studies. Molecular & Cellular Oncology, 6(2): 1575691.
  • Townsend, M.H., Robison, R.A., & O’Neill, K.L. (2018b). A review of HPRT and its emerging role in cancer. Medical Oncology, 35(6): 89.
  • Wang, L., Wang, Y., Han, N., Wang, X., & Ruan, M. (2021). HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. Experimental Cell Research, 399(1): 112424.

Yıl 2022, Cilt: 7 Sayı: 2, 210 - 219, 31.08.2022
https://doi.org/10.31797/vetbio.1086702

Öz

Kaynakça

  • Beytut, E. (2017). Pathological and immunohistochemical evaluation of skin and teat papillomas in cattle. Turkish Journal Veterinary Animal Science, 41 (2), 204-12.
  • Biricik, H.S., Çimtay, İ., Keskin, O., & Baba, Z.F. (2002). Bir Boğada Gözlenen Penis Fibropapillomunun Sağaltımında Otolog Aşı ve Otohemoterapi Kombinasyonunun Etkisi. Veteriner Hekimleri Mikrobiyoloji Dergisi, 2(2);13-6.
  • Bulut. S., & Ünsaldı, S. (2001). Sığırlarda Gözlenen Penis Fibropapillomlarının Operatif Sağaltımı. Fırat Üniversitesi Sağlık Bilimleri Dergisi, 15(1):139-144.
  • Hatipoğlu, F., Özdemir, O., & Kıran, M.M. (2009). Detection of argyrophil nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in epithelial skin tumours from domestic animals. Revue Médicina Véterinaria, 160(10): 477-83.
  • Heppelman, M., Strüve, K., Hansmann, F., Seehusen, F., & Kehler, W. (2019). Urethral fistula after resection of a penile fibropapilloma in a Holstein Friesian bull. Schweizer Archiv Fur Tierheilkunde, 161; 553-557.
  • Sedano, M., Ramos, E., Choudhari, R., Harrison, A., Subramani, R., Lakshmanaswamy, R., Zilaie, M., & Gadad, S.S. (2020). Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast Cancer. Cancers (Basel), 12 (6): 1522.
  • Jelínek, F., & Tachezy, R. (2005). Cutaneous papillomatosis in cattle. Journal of Comparative Pathology, 132(1):70-81.
  • Kamiloğlu, A., Öztürk, S., Kılıç, E., & Aksoy, Ö. (2004). Boğalarda Penis, Prepisyum Hastalıkları ve Sağaltım Olanakları: 150 Olgu (2000-2003). Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 10(1):31-36.
  • Kaya, M., Okumuş, Z., Doğan, E., Yanmaz, L.E., & Çetin, E.M. (2010). Boğalarda Penis ve Preputium Hastalıklarının Değerlendirilmesi. Fırat Üniversitesi Sağlık Bilimleri Dergisi,24 (3): 149 – 156.
  • Kelman, Z. (1997). PCNA structure, functions and interactions. Oncogene 14:629–640.
  • Khodakaram, T.A., & Kargar, M. (2009). Gross and histopathologic characteristics of penile fibropapillomas in young bulls. Comparative Clinical Pathology, 18:261–263.
  • Maeda, Y., Shibahara, T., Wada, Y., Kadota, K., Kanno, T., Uchida, I., & Hatama, S. (2007). An outbreak of teat papillomatosis in cattle caused by bovine papilloma virus (BPV) type 6 and unclassified BPVs. Veterinary Microbiology, 121:242-248.
  • Maga, G., & Hübscher, U. (2003). Proliferating cell nuclear antigen (PCNA): a dancer with many partners. Journal of Cell Science, 116:3051-60.
  • Özsoy, Ş.Y., Özyıldız, Z., & Güzel, M. (2011). Clinical, pathological and immuno-histochemical findings of bovine cutaneous papillomatosis. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 58: 161-5.
  • Townsend, M.H., Anderson, M.D., Weagel, E.G., Velazquez, E.J., Weber, K.S., Robison, R.A., & O'Neill, K.L. (2017). Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane. OncoTargets and Therapy. 10:1921-32.
  • Townsend, M.H., Bennion, K.B., Bitter, E.E., Felsted, A.M., Robison, R.A., & O'Neill, K.L. (2021). Overexpression and surface localization of HPRT in prostate cancer provides a potential target for cancer specific antibody mediated cellular cytotoxicity. Experimental Cell Research. 403 (1):112567.
  • Townsend, M.H., Felsted, A.M., Burrup, W., Robison, R.A., & O'Neill, K.L. (2018a). Examination of Hypoxanthine Guanine Phosphoribosyltransferase as a biomarker for colorectal cancer patients. Molecular & Cellular Oncology, 5(4):e1481810.
  • Townsend, M.H., Felsted, A.M., Ence, Z.E., Piccolo, S.R., Robison, R.A., & O’Neill, K.L. (2019). Falling from grace: HPRT is not suitable as an endogenous control for cancer-related studies. Molecular & Cellular Oncology, 6(2): 1575691.
  • Townsend, M.H., Robison, R.A., & O’Neill, K.L. (2018b). A review of HPRT and its emerging role in cancer. Medical Oncology, 35(6): 89.
  • Wang, L., Wang, Y., Han, N., Wang, X., & Ruan, M. (2021). HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. Experimental Cell Research, 399(1): 112424.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm Araştırma Makaleleri
Yazarlar

Uğur AYDIN
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0001-5756-4841
Türkiye


Emin KARAKURT
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0003-2019-3690
Türkiye


Serpil DAĞ
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0001-7667-689X
Türkiye


Enver BEYTUT
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0003-3360-2940
Türkiye


İsa ÖZAYDIN
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0003-4652-6377
Türkiye


Hilmi NUHOĞLU
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0003-2530-2542
Türkiye


Uğur YILDIZ
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0002-4782-1012
Türkiye


Ayfer YILDIZ
KAFKAS ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0002-6569-5435
Türkiye


Emre KURTBAŞ
KAFKAS ÜNİVERSİTESİ
0000-0002-9752-194X
Türkiye

Yayımlanma Tarihi 31 Ağustos 2022
Gönderilme Tarihi 12 Mart 2022
Kabul Tarihi 24 Temmuz 2022
Yayınlandığı Sayı Yıl 2022 Cilt: 7 Sayı: 2

Kaynak Göster

APA Aydın, U. , Karakurt, E. , Dağ, S. , Beytut, E. , Özaydın, İ. , Nuhoğlu, H. , Yıldız, U. , Yıldız, A. & Kurtbaş, E. (2022). Clinical and immunohistochemical evaluation of penile tumors in bulls . Journal of Advances in VetBio Science and Techniques , 7 (2) , 210-219 . DOI: 10.31797/vetbio.1086702

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