Investigation of diamine oxidase as a biomarker of intestinal mucosal injury in calves exposed to antibacterial treatment

Year 2024, Volume: 9 Issue: 3, 190 - 196, 27.12.2024

Deniz Alıç Ural

https://doi.org/10.31797/vetbio.1423891

Abstract

Diamine oxidase (DAO) (alternatively old-fashioned name histaminases), as being an enzyme in high concentrations, support the integrity and maturation of small intestine. Histamine intoxication and related issues are suggested to exist lacking enzyme diamine oxidase. Enrollment of the gastrointestinal mucosa in several diseases, along with influence of some medications seemed to diminish gastrointestinal DAO activity. The aim of this study was to investigate intestinal mucosal injury in sick calves exposed to antibiotic treatment. In accordance with the inclusion criteria, 20 sick calves with gastroenterologic or respiratory system problems exposed to antibiotic treatment for >3 weeks and 10 other healthy calves were evaluated. Commercially available DAO ELISA kit: Bovine Diamine Oxidase ELISA Kit and Sandwich ELISA-mediated DAO assays were performed. In this study, the mean DAO (ng/mL) level was determined as 5.552 in sick calves exposed to antibiotic treatment, while the mean value was determined as 16.48 in healthy calves in the comparative evaluation (p<0.001). The data obtained suggest that DAO activity may be affected in calves exposed to antibiotic treatment for at least 3 weeks.

Keywords

Antibiotics, Calves, Diamine oxidase, Mucosal injury

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