Aşırı aktif mesane ile C-reaktif protein ve eritrosit sedimantasyon hızının ilişkisi

Abstract

Amaç: Hastaların yaşam kalitesini olumsuz olarak etkileyen aşırı aktif mesanenin (OAB) kesin nedeni bilinmemektedir. Bu çalışma bugüne kadar etyolojisi tam olarak aydınlatılamayan OAB’li hastalarda inflamatuar sürece ilişkin kanıtlar sağlamak amacıyla planlandı. Gereç ve Yöntemler: Çalışmaya OAB tanısı alan 154 kişi ile kontrol için kullanılan 131 kişi kaydedildi. Çalışma Nisan 2015 ile Nisan 2020 yılları arasında retrospektif, kesitsel olarak yapıldı. Veriler bu konuda uzman bir kişi tarafından, ilk görüşmede kaydedildi. Gruplar serumda ölçülen CRP ve ESR açısından karşılaştırıldı. İstatistiksel analizde Ki-kare testi, Bağımsız örneklemler t-testi, Mann-Whitney U testi, Pearson ve Spearman korelasyon analizleri kullanıldı. P<0.05 düzeyi istatistiksel olarak anlamlı kabul edildi. Bulgular: Gruplar arasında ek hastalıklar açısından farklılık saptanmadı. Yaş ve BMI açısından gruplar arasında anlamlı farklılık saptandı (p<0.005). Gruplara göre CRP düzeyleri karşılaştırıldığında, OAB grubu için 0.28 [0.54] ve kontrol grubu için 0.17 [0.22] mg/dl olarak saptandı (p=0.047). ESH’nın gruplara göre dağılımı sırasıyla için 19 [30.5] ve 12.5 [13] mm/h olarak izlendi (p=0.004). Sonuç: Bu çalışma OAB ile inflamatuar bir süreç arasındaki ilişkiyi gösteren bilgilerimize yeni kanıtlar sunmaktadır. OAB’li hastalarda CRP ve ESH düzeylerinin kontrol grubuna göre arttığı saptandı. Bu sonuçlar bize bu hastalığın temelinde inflamatuar bir sürecin olduğunu göstermektedir.

Keywords

• İnflamasyon
• aşırı aktif mesane
• C-reaktif protein
• eritrosit sedimantasyon hızı

An examination of relationship between overactive bladder and C-reactive protein and erythrocyte sedimentation rate

Abstract

Objective: The definite cause of overactive bladder (OAB), which negatively affects the quality of life of patients, is unknown. This study aims to provide evidence for the inflammatory process in patients with OAB whose etiology has not been fully elucidated. Material and Methods: The study included 154 people with OAB diagnosis and 131 people as controls. This study was conducted retrospectively, cross-sectionally between April 2015 and April 2020. The data were recorded at the first meeting by an expert on this subject. Groups were compared in terms of CRP and ESR measured in serum. Statistical analysis used the chi-square test, independent samples t-test, Mann-Whitney U test, and Pearson and Spearman correlation analyses. P<0.05 was accepted as statistical significance. Results: There were no differences between the groups in terms of comorbid diseases. There were significant differences identified in terms of age and BMI between the groups (p<0.005). When groups are compared according to CRP levels, values were 0.28 [0.54] for the OAB group and 0.17 [0.22] mg/dl for the control group (p=0.047). The distribution according to ESR in the groups was 19 [30.5] and 12.5 [13] mm/h, respectively (p=0.004). Conclusion: This study provides new evidence to the literature showing the relationship between OAB and an inflammatory process. It was determined that CRP and ESR levels were increased in patients with OAB compared to the control group. These results show us that there is an inflammatory process at the onset of this disease.

Keywords

• Inflammation
• overactive bladder
• C-reactive protein
• erythrocyte sedimentation rate

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