Relation of neutrophil lymphocyte ratio with tumor characteristics in localized kidney tumors

Year 2018, Volume: 13 Issue: 1, 12 - 15, 01.02.2018

Semih Tangal Kutsal Önal Metin Yığman , Ahmet Hakan Haliloğlu

Abstract

Aim: Considering that neutrophil/lymphocyte ratio is indicated as prognostic factor in many urologic neoplasms, the purpose of this paper is to examine the relation between this ratio and characteristics of tumors in localized kidney tumors. 

Material and Methods: Laboratory and pathology results of 125 patients operated in our clinic with the diagnosis of renal lump were examined retrospectively. Neutrophil/ lymphocyte ratios (NLR) of all patients were detected by an examination of pre-operation complete blood cell counts. The relations between NLR and size, side, location, histological type and Fuhrman degree of tumor were assessed statistically. 

Findings: Statistically significant relations could not be detected among preoperative NLR and sex and age of patients and size, side and location of tumor (p<0.05). Also, when tumors were divided into two as benign and malign and malign ones were grouped into two as tumors with and without clear cells, statistically significant relations could not be reported between NLR and these groups (p>0.05). A statistically significant relation could not be found between NLR and Fuhrman degrees obtained from clear cell tumor pathology reports (p>0.05). 

Conclusion: Although it is thought that NLR is a variable independent from the other prognostic factors in the kidney tumors, more comprehensive studies are needed due to different results available in the literature. 

Keywords

Neutrophil lymphocyte ratio , kidney tumor

Nötrofil lenfosit oranının lokalize böbrek tümörlerinde tümör özellikleri ile ilişkisi

Abstract

Amaç: Nötrofil/Lenfosit oranının birçok ürolojik tümörde prognostik faktör olduğu gösterilmesine karşın lokalize böbrek tümörlerinde tümörün özellikleri ile ilişkisini araştırmayı amaçladık. 

Gereç ve Yöntemler: Kliniğimizde renal kitle tanısı ile opere edilen 125 hastanın laboratuvar ve patoloji sonuçları geriye dönük olarak incelendi. Tüm hastaların operasyon öncesi yapılan tam kan sayımlarından nötrofil/lenfosit oranı(NLR) tespit edildi. NLR’nin tümörün boyutu, tarafı, lokalizasyonu, histolojik tipi ve Fuhrman derecesi arasındaki ilişki istatistiksel olarak değerlendirildi. 

Bulgular: Preoperatif hesaplanan NLR ile hastaların cinsiyet ve yaş faktörleri, tümörün tarafı, lokalizasyonu, boyutu ile istatistiksel olarak anlamlı bir ilişki saptanmadı (p>0,05). Ayrıca tümör histopatolojilerine göre benign ve malign olarak, malign tümörlerde ise berrak hücreli olan ve olmayan olarak ikili gruplandırıldıklarında da NLR ile gruplar arasında istatistiksel olarak anlamlı bir ilişki izlenmedi (p>0,05). Berrak hücreli tümör patoloji raporlarından elde edilen Fuhrman dereceleri ile NLR arasında da istatistiksel olarak anlamlı bir sonuç saptanmadı (p>0,05). 

Sonuç: NLR’nin böbrek tümörlerinde diğer prognostik faktörlerden bağımsız bir değişken olduğu düşünülmesine rağmen literatürdeki farklı sonuçlardan dolayı daha kapsamlı geniş çalışmalara ihtiyaç vardır. 

Keywords

Nötrofil lenfosit oranı , böbrek , tümörü

References

• 1. Li W, Cheng Y, Cheng Y et al. Clinical efficacy of radical nephrectomy versus nephron-sparingsurgery on localized renal cell carcinoma. Eur J MedRes 2014;19:58.
• 2. Shuch BM, Lam JS, Belldegrun AS et al. Prognostic factors in renal cell carcinoma. Semin Oncol 2006;33:563-75.
• 3. Mantovani A, Allavena P, Sica A et al 2008 Cancerrelated inflammation. Nature 2008;454:436–444.
• 4. Elinav E, Nowarski R, Thaiss CA et al.Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. NatRev Cancer 2013;13:759-71.
• 5. Roxburgh CS, McMillan DC. Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol 2010 ;6:149-63.
• 6. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999 Feb 11;340:448-54. Review. Erratum in: N Engl J Med 1999;340:1376.
• 7. Jensen HK, Donskov F, Marcussen N et al. Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. J ClinOncol 2009;27:4709- 17.
• 8. Trellakis S, Farjah H, Bruderek K et al. Peripheral blood neutrophil granulocytes from patients with head and neck squamous cell carcinoma functionally differ from their counterparts in healthy donors. Int J Immunopathol Pharmacol 2011;24:683-93.
• 9. Ceylan C, Camtosun A, Doluoglu OG et al. Emphasis of neutrophil-to-lymphocyte ratio in non-metastatic renal cell carcinoma. Urologia 2014;81:51-6.
• 10. Keegan KA, Schupp CW, Chamie K et al. Histopathology of surgically treated renal cell carcinoma: survival differences by subtype and stage. J Urol 2012;188:391-7.
• 11. Lang H, Lindner V, de Fromont M et al. Multicenter determination of optimal interobserver agreement using the Fuhrman grading system for renal cell carcinoma: Assessment of 241 patients with >15-year follow-up. Cancer 2005;103:625-9.
• 12. Wen RM, Zhang YJ, Ma S et al. Preoperative Neutrophil to Lymphocyte Ratio as a Prognostic Factor in Patients with Non-metastatic Renal Cell Carcinoma. Asian Pac J Cancer-Prev 2015;16:3703-8.
• 13. Hu H, Yao X, Xie X et al. Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients. World J Urol 2016 Jun 2. 14. Bazzi WM, Dejbakhsh SZ, Bernstein M et al. Neutrophil-lymphocyte ratio in small renal masses. ISRN Urol 2014;2014:759253.
• 15. Pichler M, Hutterer GC, Stoeckigt C et al. Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients. Br J Cancer 2013;108:901-7.
• 16. Bazzi WM, Tin AL, Sjoberg DD et al. The prognostic utility of preoperative neutrophil-to-lymphocyte ratio in localized clear cell renal cell carcinoma. Can J Urol 2016;23:8151-4.
• 17. de Martino M, Pantuck AJ, Hofbauer S et al. Prognostic impact of preoperative neutrophil-to-lymphocyte ratio in localized non clear cell renal cell carcinoma. J Urol. 2013;190:1999-2004.