Emphasis of neutrophil to lymphocyte for prediction of Gleason groups in patient who underwent prostate biopsy

Abstract

Aim: In this study we aimed to determine the status of the neutrophil lymphocyte ratios of the new ISUP Gleason groups.

Material and Methods: Patients who underwent transrectal ultrasound-guided prostate biopsy and who had pathologically proven prostate cancer were evaluated retrospectively. Neutrophil / lymphocyte ratios of all patients were determined. Their age, PSA values and body mass index (BMI) were recorded. Patients were assigned to 5 Gleason groups according to ISUP 2014 definition. N / L ratios and other demographic data of the groups were compared with each other.

Results: Data from 86 patients meeting the study criteria were recorded. N/L ratios were found as 2.13 (0.27-9.28) in group 1, 2.22 (0.27-1.52) in group 2, 2.40 (1.41-6.30) in group 3, 1.90 (0.91-2.99) in group 4 and 2.11 (0.27-3.62) in group 5 (p=0.74).

Conclusion: N / L ratio was found to be similar in all Gleason groups according to present study. Prospective studies with large patient populations are needed to determine whether N / L ratio is a prognostic factor in localized PCa patients or not.

Keywords

• Gleason score,neutrophil to lymphocyte ratio,prostate cancer

Prostat biyopsisi yapılan hastalarda Gleason gruplarının tahmininde nötrofil/ lenfosit oranının önemi

Abstract

Amaç: Biz bu çalışmada lokalize prostat kanserlerinde Gleason gruplarına göre, N/L oranları arasında önemli bir fark olup olmadığını araştırmayı amaçladık.

Gereç ve Yöntemler: Transrektal ultrason eşliğinde prostat biyopsisi yapılan ve patoloji sonucu prostat kanseri gelen hastalar retrospektif olarak incelendi. Tüm hastaların nötrofil/lenfosit oranları belirlendi. Yaşları, PSA değerleri ve vücut kitle indeksleri (BMI) kaydedildi. Hastalar ISUP 2014 tanımlamasına göre 5 gleason grubuna ayrıldı. Grupların N/L oranları ve diğer demografik verileri birbirleri ile karşılaştırıldı.

Bulgular: Çalışma kriterlerine uyan 86 hastanın verileri kaydedildi. Grupların N/L oranları birbirleri ile karşılaştırıldığında Grup 1’de 2.13 (0.27-9.28), grup 2’de 2.22 (0.27-1.52), grup 3’de 2.40 (1.41-6.30), grup 4’de 1.90 (0.91-2.99) ve grup 5’de 2.11 (0.27- 3.62) olarak saptandı (p=0.74).

Sonuç: Çalışmamıza göre N/L oranının tüm Gleason gruplarında benzer olduğu saptanmıştır. N/L oranının lokalize PCa hastalarında prognostik bir faktör olup olmadığını saptamak için geniş hasta serili prospektif çalışmalara ihtiyaç vardır.

Keywords

• Gleason skor,Nötrofil lenfosit oranı,Prostat kanseri

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