The Role of Neutrophil-lymphocyte Rate in Treatment Resistant Patients in Treatments With Urinary Tract Infection

Year 2020, Volume: 15 Issue: 1, 33 - 38, 26.02.2020

Ergün Alma , Hakan Erçil , Adem Altunkol , Güçlü Gürlen Ediz Vuruşkan Onur Küçüktopçu Zafer Gökhan Gürbüz

https://doi.org/10.33719/yud.617948

Abstract

Objective: To evaluate the
role of neutrophil-lymphocyte ratio in treatment resistance and follow-up in
pregnant women with lower urinary tract infection.

Materials and methods: The data of 88 pregnant women with
UTI complaints between September 2016 and December 2018 were retrospectively
reviewed. Patients with stone disease, JJ stent or nephrostomy placement, and
urinary system anatomic malformation that complicate the etiology were excluded
from the study. Patients were divided into two groups according to their first
and third day medical treatment.

Results: Group A consisted of 64 patients with a mean
age of 23.7 ± 4.7 years and group B consisted of 24 patients with 24.4 ± 6.0
years. The mean NLR at the first visit was 4.7 +
1.2 in group A and 7.1 + 1.9 in group B. In group B, this value was 6.7 ± 2.1
on the third day after empirical treatment and the difference was not
statistically significant (p> 0.05). At the end of the treatment period, the
mean NLR in group A decreased to 2.4 + 1.0, and it decreased to 1.4 + 0.6 in
group B(P <0.05). The cutoff value for NLR was 6.15 (sensitivity 0.76,
specificity 0.86, and P <0.001). When all patients were compared
according to this cutoff value, 9 (14%) and 19 (79.1%) patients in group A had
NLR levels above this value at the first admission (P <0.001).

Conclusion: NLR is a marker that can be useful to the clinician
both in determining the treatment-resistant patient group and in following the
response to treatment.

Keywords

Urinary tract infection , Neutrophil-lymphocyte ratio , Pregnant

Üriner Sistem Enfeksiyonu Olan Gebelerde Nötrofil Lenfosit Oranının Tedaviye Dirençli Hastaları Tahmin Etmede ve Tedavinin Takibindeki Rolü

Abstract

Giriş: Üriner
sistem enfeksiyonu(ÜSE) olan gebelerde nötrofil lenfosit oranının(NLO) tedaviye
direnç ve takipteki rolünü değerlendirmek.

Gereç ve
Yöntemler: Eylül2016-Aralık 2018 tarihleri arasında ÜSE şikayetleri ile
başvuran 88 gebenin kayıtları retrospektif olarak incelendi. Etyolojiyi daha da
komplike hale getiren taş hastalığı, JJ stent ya da nefrostomi yerleştirilmesi,
üriner sistem anatomik malformasyonu olan hastalar çalışmadan dışlandı. Hastalar
ilk ve üçüncü günkü medikal tedavisine göre iki gruba ayrılarak
değerlendirildi.

Bulgular: Grup
A’ da yaş ortalaması 23.7±4.7 olan 64 hasta ve grup B’ de24.4±6.0 olan 24
hastadan oluşmaktaydı. İlk başvuruda NLR ortalaması grup’ A da 4.7+1.2 ve grup’ B de
7.1+1.9 idi. Grup’ B de ampirik tedavi sonrası 3. günde bu değer 6,7±2,1 idi ve
aradaki farklılık istatistiksel olarak anlamlı değildi(P >0.05). Tedavi
süreci sonunda grup’ A da NLR ortalaması 2.4+1.0’a gerilerken, grup’ B de ise
1.4+0.6 düzeyine gerilemişti(P<0.05). NLR için cutoff değeri 6.15 olarak
belirlendi(Sensitivite 0.76, spesifite 0.86 ve P <0,001).

NLO için cutoff
değeri 6.15 olarak belirlendi(sensitivite 0.76, spesifite 0.86 ve p<0,001).
Tüm hastalar bu cutoff değerine göre tekrar karşılaştırıldığında ilk başvuruda
grup A’ da 9(%14) ve grup’ B de19 (%79.1) hasta bu değerin üzerinde NLO
seviyesine sahipti(P<0.001).

Sonuç: NLO
hem tedaviye dirençli hasta grubunun belirlenmesinde hem de tedaviye yanıtın
izlenmesinde klinisyene yararlı olabilecek bir belirteçtir.

Keywords

üriner sistem enfeksiyonu , lenfosit nötrofil oranı , gebe

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