Yaşlanan Erkekte Benign Prostat Hiperplazisine Bağlı Alt Üriner Sistem Semptomları İle Vitamin D Seviyesi Arasındaki İlişki

Abstract

Amaç: 40 yaşın üzerindeki erkeklerde vitamin D düzeyleri ile benign prostat hiperplazisi (BPH) ne bağlı alt üriner sistem semptomları (AÜSS) arasındaki ilişkiyi belirlemeyi amaçladık.
Gereç Ve Yöntemler: Çalışmamıza Ocak 2019- Nisan 2019 tarihleri arasında kliniğimize BPH’ya bağlı AÜSS ile başvuran 48 hasta (BPH grubu) ile AÜSS olmayan ve rutin ürolojik kontrole gelen 52 hasta (Kontrol grubu) dahil edildi. Her iki grubun vitamin D, total PSA, total testosteron değerleri, IPSS skorları, prostat hacimleri ve üroflowmetrideki maksimum idrar hızı (Qmax) değerlendirildi.
Bulgular: BPH grubundaki 48 hastanın yaş ortalaması 65,37 ± 7,24, kontrol grubundaki 52 hastanın yaş ortalaması 64,09 ± 8,22 idi. BPH ve kontrol grupları arasında 25 hidroksi vitamin D değerlerinin ortalama değerleri açısından istatistiksel olarak anlamlı bir fark vardı (p <0.001). BPH grubundaki hastalar alt gruplarına göre incelendiğinde; Orta AÜSS (33 hasta) ve şiddetli AÜSS (15 hasta) grubu arasında 25 hidroksi vitamin D düzeyi açısından istatistiksel olarak anlamlı fark yoktu (p> 0.05).
Sonuç: Çalışmamız BPH ve AÜSS olan hastalarda 25 hidroksi vitamin-D düzeylerinin şikayeti olmayan benzer yaş grubundakilerden düşük olduğunu göstermiştir. Buna dayanarak, vitamin D düzeylerinde artış olan hastaların semptomlarında bir iyileşme olabileceği düşünülmektedir. Bu konuda kesin bir karara varmak için, daha fazla sayıda randomize kontrollü prospektif çalışmaya ihtiyaç vardır.

Keywords

• Vitamin D,benign prostat hiperplazisi,alt üriner sistem semptomları

The Relationship Between Benign Prostate Hyperplasia Related Lower Urinary Tract Symptoms And Vitamin D Level in Aging Male

Abstract

Objective: We aimed to determine the relationship between vitamin D levels and benign prostate hyperplasia BPH) related lower urinary tract symptoms (LUTS) in men over 40 years of age.
Material and Methods: The study was conducted prospectively between January and April 2019 and included 48 patients who presented to the outpatient clinic with lower urinary tract symptoms and who had not received medical or surgical treatment due to BPH (BPH group) and 52 healthy men (Control group) who did not have lower urinary tract symptoms and applied to the outpatient clinic for routine urological control. Vitamin D, total PSA, total testosterone values, IPSS scores, prostate volumes and maximum urinary velocity in uroflowmetry (Q max) of both groups were evaluated.
Results: The mean age of 48 patients with benign prostatic hyperplasia in BPH group was 65.37 ± 7.24 and in control group without urinary tract symptoms was 64.09 ± 8.22. There was a statistically significant difference between BPH and control groups in terms of the mean values of 25 hydroxy vitamin-D values (p< 0.001). When the patients diagnosed with BPH were examined according to their subgroups; there was no statistically significant difference in terms of 25 hydroxy vitamin D level between moderate LUTS (33 patients) and severe LUTS (15 patients) groups(p> 0.05).
Conclusion: Our study has shown that in patients with BPH and LUTS, 25 hydroxy vitamin D levels were lower than those in the similar age group without any complaints. Based on this, it was thought that there might be an improvement in the symptoms of patients with increasing vitamin D levels. To reach a final judgment on this subject, larger number of randomized controlled prospective studies are needed.

Keywords

• Vitamin D,benign prostate hyperplasia,, lower urinary tract symptoms

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