Nephrogenic adenomas of the urinary system: a clinicopathologic analysis of 30 cases

Year 2021, Volume: 16 Issue: 2, 95 - 100, 29.06.2021

Berna Aytaç Vuruşkan , Ezgi Işıl Turhan , Hakan Vuruşkan , İsmet Yavaşcaoğlu

https://doi.org/10.33719/yud.2021;16-2-747110

Abstract

Objective: Nephrogenic adenomas (NA) are benign lesions that may occur in several sites throughout the urinary tract, from the renal pelvis to urethra, and especially in the bladder. They are strongly associated with urinary tract irritation, chronic inflammation, previous urologic surgery, and intravesical instrumentations. Our study aims to evaluate and present the clinicopathologic characteristics and findings of cases that were diagnosed with nephrogenic adenoma accompanied by relevant information from the literature.

Material and Methods: Our study includes 30 patients who were pathologically diagnosed with NA from February 2005 to November 2017.

Results: Among these patients, 63.3% were males and mean age was 60 years. The most common site of occurrence was the bladder (86.6%), followed by the ureter (6.7%) and the urethra (6.7%). Most patients presented with hematuria (36.7%). History of concurrent bladder cancer was present in 26.7% of patients, but there were no cases of de novo bladder cancer diagnosed after NA. Recurrence of NA after initial resection occurred in only 10% of patients who underwent follow-up cystoscopy. Nephrogenic adenoma is a rare lesion associated with nonspecific symptoms and endoscopic features. Definite diagnosis must be made after histological analysis of resected specimens.

Conclusion: Nephrogenic adenoma is a rare lesion associated with nonspecific symptoms and nonspesific endoscopic features. A definite diagnosis must be after histological analysis of resected specimens. 

Keywords

Nephrogenic adenoma , urothelial lesion , bladder , ureter

Üriner sistemin nefrojenik adenomları: 30 vakanın klinikopatolojik analizi

Abstract

Amaç: Nefrojenik adenom (NA), en sık mesane olmak üzere üriner sistemin değişik yerlerinde oluşan benign bir lezyondur. Üriner sistem irritasyonu, kronik inflamasyon, geçirilmiş ürolojik cerrahi ve intravezikal enstrümantasyon ile ilişkilidir. Çalışmamızda, nefrojenik adenom tanısı almış olguların klinikopatolojik özelliklerinin ve sonuçlarının güncel literatür bilgileri eşliğinde incelenerek sunulması amaçlanmıştır.

Gereç ve Yöntemler: Çalışmamıza Şubat 2005- Kasım 2017 yılları arasında Nefrojenik adenom patolojik tanısı almış 30 hasta dahil edildi.

Bulgular: 30 hastanın % 63,3’ü erkekti ve ortalama yaş 60 olarak bulundu. Olgular mesane (%86,6), üreter (%6,7) ve üretra (%6,7) yerleşimliydi. En sık hematüri (%36,7) klinik bulgusu görülmüştü. Hastaların %26,7’sinde eşlik eden mesane kanseri öyküsü mevcuttu ancak hiçbir hastada nefrojenik adenom tanısı sonrası yeni gelişen mesane kanseri mevcut değildi. İlk rezeksiyon sonrası takip sistoskopilerinde %10 hastada rekürrens görüldü.

Sonuç: Nefrojenik adenomlar nonspesifik semptom ve endoskopik bulgular gösteren nadir lezyonlardır. Bu nedenle doğru tanı rezeksiyon materyalinin histolojik değerlendirilmesi ile konulmalıdır.

Keywords

Nefrojenik adenom , ürotelyal lezyon , mesane , üreter

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