Evaluation of Complete Blood Count in Chronic Lymphoid Leukemia Patients

Yıl 2025, Cilt: 6 Sayı: 1, 61 - 67, 13.01.2025

Ayşe Dalyan , Sibel Bayıl Oguzkan , Mehmet Özaslan

https://doi.org/10.55549/zbs.1586463

Öz

Chronic Lymphoid Leukemia (CLL) is characterized by the uncontrolled proliferation of lymphocytes, usually in the elderly, which can lead to various hematological abnormalities in patients. Analysis of hematological parameters is very important for the diagnosis, prognosis, and monitoring of treatment response in CLL. This study aimed to compare the complete blood count (CBC) parameters of CLL patients with a healthy control group. The study included 50 patients diagnosed with CLL and 50 healthy controls without a history of cancer. CBC parameters (WBC, RBC, HGB, HCT, MCV, MCH, MCHC, RDW, RDW-SD, PDW, PLT, MPV, PCT, NEU%, LYM%, MONO%, EOS%, BASO%, NEU#, LYM#, MONO#, EOS#, BASO#, NRBC#) of CLL patients and control group were statistically compared. According to the analysis results, no significant difference was found between MCV, RDW, RDW-SD, PDW, MPV, BASO%, NEU#, and EOS# values of the patient and control groups (p>0.05). However, WBC, RBC, HGB, HCT, LYM%, MONO%, LYM#, MONO#, BASO#, and NRBC# values of the patient group were significantly higher relative to the control group (p<0.05). MCH, MCHC, PLT, PCT, NEU%, and EOS% parameters were significantly higher in the control group relative to the patient group (p<0.05). As a result, significant differences were observed in some CBC parameters between patients and the control groups. Particularly, the significant difference observed in some parameters emphasizes that the hematological profile of CLL can be used in the diagnosis and monitoring processes. Our findings support

Anahtar Kelimeler

CLL, Prognosis, CBC, Leukemia, Hematological parameters

Etik Beyan

Local ethics committee approval was obtained for the study with protocol number 2021/163.

Teşekkür

We thank Prof. Dr. Mehmet Yılmaz for his help in collecting samples from Sanko University Hospital for our study. This study was presented as an oral presentation at the X. Experimental Hematology Congress with International Participation.

Kaynakça

• Ali, Y. B., Foad, R. M., & Abdel-Wahed, E. (2017). Lack of Associations between TLR9 and MYD88 Gene Polymorphisms and Risk of Chronic Lymphocytic Leukemia. Asian Pacific journal of cancer prevention : APJCP, 18(12), 3245–3250. https://doi.org/10.22034/APJCP.2017.18.12.3245
• Devi, A., Thielemans, L., Ladikou, E. E., Nandra, T. K., & Chevassut, T. (2022). Lymphocytosis and chronic lymphocytic leukaemia: investigation and management. Clinical medicine (London, England), 22(3), 225–229. https://doi.org/10.7861/clinmed.2022-0150
• Hayran, M., Koca, E., Haznedaroglu, I. C., Unsal, I., Durgun, B., Guvenc, F., ... & Ozcebe, O. I. (2006). Predicting chronic leukaemias from assessment of complete peripheral blood counts. Journal of international medical research, 34(6), 640-647. doi:10.1177/147323000603400609
• Hendy, O. M., El Shafie, M. A., Allam, M. M., Motalib, T. A., Khalaf, F. A., & Gohar, S. F. (2016). The diagnostic and prognostic value of CD38 and CD49d expressions in chronic lymphocytic leukemia. The Egyptian Journal of Haematology, 41(2), 70-76. doi:10.4103/1110-1067.186409
• Köroğlu A., Tangün Y., Ören H., & Tüfekçi Ö. (2014). Tam kan sayımı. hematoloji laboratuvarı kılavuzu-1. Türk Hematoloji Derneğ. Accessed August 30, 2024. https://www.thd.org.tr/thdData/Books/971/bolum-ii-tam-kan-sayimi.pdf.
• Lokwani DP.(2013). The ABC of CBC: Interpretation of complete blood count and histograms. 1st ed. New Delhi: Jaypee Brothers Medical Publishers Ltd;1-5
• Mahmoud FH, Abd El Rahman MZ, Ahmed EHA, Zahran AM.(2024). Assessment of the prognostic role of platelets-lymphocytes and neutrophil-monocyte ratios in chronic lymphocytic leukemia. SECI Oncology, 1:39-46
• Masternak, M., Puła, B., Knap, J., Waszczuk-Gajda, A., Drozd-Sokołowska, J., Wdowiak, K., Grosicki, S., Kozłowska, I., Kaźmierczak, M., Łabędź, A., Szukalski, Ł., Wiśniewski, K., Subocz, E., Hałka, J., Szymczyk, A., Hus, M., Jamroziak, K., & Giannopoulos, K. (2020). Mean Platelet Volume Has Prognostic Value in Chronic Lymphocytic Leukemia. Cancer management and research, 12, 9977–9985. https://doi.org/10.2147/CMAR.S246385
• Namazi, F., Hadi, N., Moghimi, M., Eshaghiyan, A., & Nateghi, B. (2019). Down-regulation of miR-193b-3p and miR-376a-3p in Chronic Lymphocytic Leukemia. Research in Molecular Medicine (RMM)., 6(3). doi:10.18502/rmm.v6i3.4609
• Ozbalci, D., Alanoglu, E. G., Findos, E., & Eroglu, H. N. (2023). Low plateletcrit is associated with reduced progression: Free and overall survival in chronic lymphocytic leukemia. Journal of medical biochemistry, 42(2), 274–281. https://doi.org/10.5937/jomb0-39375
• Padmanabhan, R., El Alaoui, Y., Elomri, A., Qaraqe, M. K., El Omri, H., & Yasin Taha, R. (2023). Machine Learning for Diagnosis and Screening of Chronic Lymphocytic Leukemia Using Routine Complete Blood Count (CBC) Results. Studies in health technology and informatics, 305, 279–282. https://doi.org/10.3233/SHTI230483
• Puiggros, A., Blanco, G., & Espinet, B. (2014). Genetic abnormalities in chronic lymphocytic leukemia: where we are and where we go. BioMed research international, 2014, 435983. https://doi.org/10.1155/2014/435983
• Rafiq, N., Iqbal, T., Shahid, M., & Muhammad, F. (2014). Hematological and biochemical parameters in Pakistani chronic lymphoblastic leukemia patients. Pak J Life Soc. Sci.,12(1):16-19
• Rivera, A. K. B., Latorre, A. A. E., Nakamura, K., & Seino, K. (2023). Using complete blood count parameters in the diagnosis of iron deficiency and iron deficiency anemia in Filipino women. Journal of rural medicine : JRM, 18(2), 79–86. https://doi.org/10.2185/jrm.2022-047
• Rodrigues, C. A., Gonçalves, M. V., Ikoma, M. R., Lorand-Metze, I., Pereira, A. D., Farias, D. L., Chauffaille, M. L., Schaffel, R., Ribeiro, E. F., Rocha, T. S., Buccheri, V., Vasconcelos, Y., Figueiredo, V. L., Chiattone, C. S., Yamamoto, M., & Brazilian Group of Chronic Lymphocytic Leukemia. (2016). Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia. Revista brasileira de hematologia e hemoterapia, 38(4), 346–357. https://doi.org/10.1016/j.bjhh.2016.07.004
• Seo, I. H., & Lee, Y. J. (2022). Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review. Biomedicines, 10(11), 2697. https://doi.org/10.3390/biomedicines10112697