Year 2019, Volume 20, Issue , Pages 55 - 61 2019-02-01

Recent studies have shown that many tumours are containing small population of stem cell-like cells, in other words, cancer stem cells. The rapid development of the cancer stem cell field has allowed the scientists and the clinicians to focus on another challenge, which targets cancer stem cells for new therapeutic strategies. Studies showed that novel therapeutic approaches on the selective targeting of cancer stem cells might be extremely successful for prevention of invasion, metastasis, and the relapses of tumors.

Liver cancer is the 5th most common cancer type. It has also been reported as the third most common cause of cancer related death. Recently, progression of hepatocellular carcinoma is thought to be driven by cancer stem cells. There are tremendous efforts to clarify the features of liver cancer stem cells, to identify them within other tumor cells, and finally to develop the new therapeutic models that target those cells. This review summarizes the features of liver cancer stem cells, and its importance for therapeutic approaches.

Son yıllarda yapılan araştırmalar; birçok tümörün az miktarda da olsa kök hücre benzeri özellik içeren hücreler, bir diğer değişle kanser kök hücreleri içerdiğini göstermektedir. Kanser kök hücreleri ile ilgili araştırmalar ve buna bağlı ortaya çıkan son derece hızlı gelişmeler; gerek hekimlerin gerekse bilim insanlarının bir diğer önemli konu üzerinde yoğun şekilde çalışmaya başlamalarına sebep olmuştur: Kanser kök hücrelerini hedef alan yeni tedavi stratejilerinin geliştirilmesi. Bu alandaki araştırmaların sonuçları; kanserin invazyonu, metastazı ve tekrarlamasını önlemede kanser kök hücrelerini hedef alan tedavi yaklaşımlarının son derece başarılı olabileceğini ortaya koymaktadır.

Karaciğer kanseri; tüm kanser türleri arasında 5. sırada yer almaktadır. Kansere bağlı ölümlerde ise 3. sırada yer almaktadır. Hepatosellüler karsinomanın ilerlemesinde kanser kök hücrelerinin çok önemli rolü olduğu gösterilmiştir. Karaciğer kanser kök hücrelerinin tanımlanması, diğer tümör hücrelerinden ayrılabilmesi ve bu hücreleri hedef alan yeni tedavi şekillerinin geliştirilebilmesi konularında çok önemli gelişmeler vardır. Bu derlemede; son yıllarda bu alanlarda yapılan çalışmalar esas alınarak karaciğer kanser kök hücrelerinin özellikleri ve bu hücreleri hedef alan yeni tedavi yaklaşımları özetlenmektedir.

Liver, cancer, stem cell, hepatocellular carcinoma
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Primary Language en
Subjects Biology
Journal Section Review/Derleme

Orcid: 0000-0002-4474-7371
Author: Ranan Aktas (Primary Author)
Institution: Maltepe University
Country: Turkey


Application Date: November 22, 2018
Acceptance Date: January 22, 2019
Publication Date: February 1, 2019

Bibtex @review { trkjnat486558, journal = {Trakya University Journal of Natural Sciences}, issn = {2147-0294}, eissn = {2528-9691}, address = {Trakya University}, year = {2019}, volume = {20}, pages = {55 - 61}, doi = {10.23902/trkjnat.486558}, title = {LIVER CANCER STEM CELLS}, key = {cite}, author = {Aktas, Ranan} }
APA Aktas, R . (2019). LIVER CANCER STEM CELLS. Trakya University Journal of Natural Sciences, 20 (), 55-61. DOI: 10.23902/trkjnat.486558
MLA Aktas, R . "LIVER CANCER STEM CELLS". Trakya University Journal of Natural Sciences 20 (2019): 55-61 <>
Chicago Aktas, R . "LIVER CANCER STEM CELLS". Trakya University Journal of Natural Sciences 20 (2019): 55-61
RIS TY - JOUR T1 - LIVER CANCER STEM CELLS AU - Ranan Aktas Y1 - 2019 PY - 2019 N1 - doi: 10.23902/trkjnat.486558 DO - 10.23902/trkjnat.486558 T2 - Trakya University Journal of Natural Sciences JF - Journal JO - JOR SP - 55 EP - 61 VL - 20 IS - SN - 2147-0294-2528-9691 M3 - doi: 10.23902/trkjnat.486558 UR - Y2 - 2019 ER -
EndNote %0 Trakya University Journal of Natural Sciences LIVER CANCER STEM CELLS %A Ranan Aktas %T LIVER CANCER STEM CELLS %D 2019 %J Trakya University Journal of Natural Sciences %P 2147-0294-2528-9691 %V 20 %N %R doi: 10.23902/trkjnat.486558 %U 10.23902/trkjnat.486558
ISNAD Aktas, Ranan . "LIVER CANCER STEM CELLS". Trakya University Journal of Natural Sciences 20 / (February 2019): 55-61.
AMA Aktas R . LIVER CANCER STEM CELLS. Trakya Univ J Nat Sci. 2019; 20: 55-61.
Vancouver Aktas R . LIVER CANCER STEM CELLS. Trakya University Journal of Natural Sciences. 2019; 20: 61-55.