Diagnosis and Treatment of Hypopituitarism in Adults

Yıl 2019, Cilt: 45 Sayı: 2, 225 - 229, 01.08.2019

Pınar Şişman Özen Öz Gül

https://doi.org/10.32708/uutfd.510272

Öz

Hypopituitarism is characterized by total or
partial loss of anterior and posterior pituitary gland function due to
hypophyseal or hypothalamic diseases. It causes adrenal insufficiency,
hypothyroidism, hypogonadism, growth hormone deficiency and rarely diabetes
insipidus. The most common causes of primary hypopituitarism are pituitary
adenomas and complications from surgery or radiation therapy for the treatment
of pituitary adenoma. Clinical findings are frequently associated with severity
of hormonal deficits. However hypopituitarism generally remains clinically
silent until a stressful event such as a concurrent infection or trauma. Because
of the increased morbidity and mortality, early diagnosis and prompt treatment
is important. Patients should be monitored for long-term and avoided under- or
overtreatment.

Anahtar Kelimeler

Hypopituitarism, pituitary adenoma, pituitary

Erişkinde Hipopitüitarizmin Tanı ve Tedavisi

Öz

Hipopitüitarizm hipofizer ya da hipotalamik
hastalıklar nedeniyle ön ve arka hipofiz bez fonksiyonlarında total ya da kısmi
kayıp olması ile karakterizedir. Adrenal yetmezlik, hipotiroidizm,
hipogonadizm, büyüme hormon eksikliği ve nadiren diyabetes insipidusa neden
olur. En sık nedeni hipofiz adenomları ve tedavide uygulanan cerrahi ve
radyasyon tedavisinin neden olduğu komplikasyonlardır. Klinik bulgular sıklıkla
hormonal eksikliğin şiddeti ile ilişkilidir. Bununla birlikte hipopituitarizm
genellikle eşlik eden enfeksiyon ve travma gibi strese yol açabilecek durumlara
kadar klinik olarak sessiz seyreder. Artmış morbidite ve mortaliteye yol açması
nedeniyle erken tanı ve uygun tedavi önemlidir. Hastalar uzun dönem izlenmeli
ve eksik ya da aşırı hormon replasman uygulamalarından kaçınılmalıdır. 

Anahtar Kelimeler

Hipopitüitarizm, hipofiz adenomu, hipofiz

Kaynakça

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