Glukokortikoid Reseptör Geni (NR3C1) ve Meme Kanserinde Rolü

Yıl 2018, Cilt: 1 Sayı: 2, 61 - 70, 15.10.2018

Zehra Kaya

Öz

Meme kanseri oldukça heterojen bir kanser olup, kanserin orijinine bağlı olarak adenokarsinom,

duktal, lobular ve meme ucu karsinom olarak sınıflandırılabilir. Histolojik tiplendirme dışında

meme kanseri östrojen reseptör (ER), progesteron reseptör (PR) ve epidermal büyüme faktörü

reseptör 2 (ERBB2/HER2) gibi düzenleyicilerdeki mutasyonlar ile ayrıca moleküler olarak

sınıflandırılabilir. Glukokortikoidler (GC) meme kanseri dahil birçok hastalığın tedavisinde

kullanılmaktadır. GC’ler kemoterapinin yan etkilerini azaltmak ve normal dokuyu meme

kanserinde genotoksik ilaçların uzun süreli etkilerine karşı korumak için sıklıkla bir adjuvan

tedavi olarak uygulanır. GC’lerin etkileri genellikle glukokortikoid reseptör (GR) aracılığı

ile gerçekleşir. GR etkilerinin anlaşılması meme kanseri tedavisindeki potansiyel ilgisinin

tartışılmasında önemli olacaktır. Bu derlemenin amacı, meme kanserinin gelişmesi ve

ilerlemesinde GR’nin etkilerini tanımlamaktır.

Anahtar Kelimeler

Glukokortikoid, Glukokortikoid reseptör, Meme kanseri, Kanser

Kaynakça

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