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Madde Bağımlılığı ve İnsan Evrimi

Yıl 2018, Cilt: 19 Sayı: 1, 17 - 22, 31.03.2018

Öz

Madde bağımlılığı, günümüzde insan toplumunu derinden ve çok yönlü olarak etkileyen en önemli problemlerden birisidir. Farklı amaçlarla bağımlılık yapıcı maddelerin kullanımı tarihte ilk insan topluluklarının yaşadığı dönemlere kadar uzanmaktadır. Tarih boyunca; psikotropik bitkiler ile insanoğlu arasındaki koevrim süreci, bu sürecin insan organizması üzerinde bıraktığı izler, omurgalı canlılarda amigdala gibi bağımlılık ilişkili beyin yapılarının gösterdiği değişimler ve bağımlılık sürecinde işleyen nöroadaptasyon mekanizmaları incelendiğinde, madde bağımlılığının evrimsel boyutu konusu da gündeme gelmektedir. Evrim sürecine tabi olan bir canlı olarak insanoğlunun bu davranışı da evrimsel perspektiften değerlendirildiğinde; belirli adaptasyon, doğal seçilim ve hayatta kalım mekanizmalarının madde bağımlılığı sürecinde aktif rol alan mekanizmalar ile benzerlik gösterdiği görülmüştür. Bu çalışma ile, madde bağımlılığı davranışının günümüze kadar ne tür mekanizmalarla korunmuş olduğunu incelemek; böylece bağımlılık konusuna yeni bir bakış açısı getirmek amaçlanmıştır.

Kaynakça

  • Adinoff, B. (2004) “Neurobiologic Processes in Drug Reward and Addiction.” Harvard Review of Psychiatry, 12(6), 305–320.
  • Alcaro A, Huber R, Panksepp J. (2007) “Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective.” Brain Res Rev 2007; 56: 283– 321 .
  • Bunney BS, Aghajanian GK. (1978) “d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway.” NaunynSchmiedebergs Arch Pharmacol 1978;304:255–61.
  • Charles Darwin, "On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life," 1859.
  • Cooper ML, Frone MR, Russell M, Mudar P (1995) “Drinking to regulate positive and negative emotions: a motivational model of alcohol use.” J Pers Soc Psychol 1995, 69:990-1005.
  • Dalton, D. R. (1979) “The Alkaloids: The Fundamental Chemistry— A Biogenetic Approach.” New York: Marcel Dekker, Inc.
  • Di Chiara G.(1997) “Alcohol and dopamine.” Alcohol Health Res World 21:108–14.
  • Di Chiara G. (1998) “A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use.” J Psychopharmacol 1998;12:54–67.
  • Due DL, Huettel SA, Hall WG, Rubin DC. (2002) “Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging.” Am J Psychiatry 2002;159:954–60.
  • Glocker ML, Langleben DD, Ruparel K et al. (2009) “Baby schema modulates brain reward system in nulliparous women.” Proc Natl Acad Sci 2009; 106: 9115– 9119 .
  • Glover, I. C. (1971) “Prehistoric research in Timor.” In: Mulvaney, D. J. & Golson, J., eds. Aboriginal Man and Environment in Australia, pp. 158–181. Canberra: Australian National University Press.
  • Glover, I. C. (1977) “Prehistoric plant remains from Southeast Asia, with special reference to rice.” In: Taddei, M., ed. South Asian Archaeology, pp. 7–37. Naples: Istituto Universitario Orientale
  • Gorman, C. F. (1970) “Excavations at spirit cave, North Thailand: some interim interpretations.” Asian Perspectives, 13, 79–108.Grant S, London ED, Newlin DB, et al. (1996) “Activation of memory circuits during cue-elicited cocaine craving.” Proc Natl Acad Sci US A 1996;93:12040–5.
  • Jentsch JD, Taylor JR. (1999) “Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.” Psychopharmacology (Berl) 146:373–90.
  • Johns, T. (1990) “With Bitter Herbs They Shall Eat It: Chemical Ecology and the Origins of Human Diet and Medicine.” Tucson, AZ: The University of Arizona Press.
  • Kelley AE. (2004) “Memory and addiction: shared neural circuitry and molecular mechanisms.” Neuron 2004; 44: 161– 179 .
  • Kelley AE, Berridge KC. (2002) “The neuroscience of natural rewards: relevance to addictive drugs.” J Neurosci 2002; 22: 3306– 3311.
  • Moerman, D. E. (1994) “North American food and drug plants.” In: Etkin, N. L., ed. Eating on the Wild Side, pp. 166–181. Tucson: The University of Arizona Press
  • Pabba, M. (2013). “ Evolutionary development of the amygdaloid complex.” Frontiers in Neuroanatomy, 7, 27.
  • Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. (1987) “Cocaine receptors on dopamine transporters are related to self-administration of cocaine.” Science 1987;237:1219–23.
  • Sullivan, R. J., Allen, J. S., Otto, C., Tiobech, S. & Nero, K. (2000) “The effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia.” British Journal of Psychiatry, 177, 174–178.
  • Sullivan RJ, Hagen EH (2002) “Psychotropic substance-seeking: evolutionary pathology or adaptation?” Addiction 2002, 97:389-400.
  • Tammy Saah (2005) “The evolutionary origins and significance of drug addiction.” Harm Reduction Journal 2:8
  • Waterman, P. G. (1998) “Chemical taxonomy of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 87–107. New York: Plenum Press.
  • Wink, M. (1993) “Allelochemical properties or the raison d’être of alkaloids.” In: Cordell, G., ed. Alkaloids, pp. 1–118. San Diego: Academic Press.
  • Wink, M. (1998a) “Chemical ecology of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 265–300. New York: Plenum Press.
  • Wink, M. (1998b) “Modes of action of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 301–326. New York: Plenum Press.
  • Yen, D. E. (1977) “Hoabinhian horticulture? The evidence and the questions from Northwest Thailand.” In: Allen, J., Golson, J. & Jones, R., eds. Sunda and Sahel, pp. 567–600. New York: Academic Press.

Substance Addiction and Human Evolution

Yıl 2018, Cilt: 19 Sayı: 1, 17 - 22, 31.03.2018

Öz

Today, substance addiction is one of the major problems that affects the human population multidirectionally and deeply. The use of the addictive substances for various purposes dates back to the times when the fist human communities lived. When some of the main issues that have taken places throughout the history are examined, such as the coevolution between the psychotropic plants and mankind the signs that this process leaves on the human organism, the evolution of addiction related brain structures such as amygdala in vertebrate organisms and the neuroadaptation mechanisms that operate in the addiction process; the evolutionary dimensions of the substance addiction comes into question. When this behavior of humanbeing as a living being subject to the evolutionary process is evaluated from an evolutionary perspective, specific adaptation, natural selection, and survival mechanisms are similar to those that take an active role in the substance addiction process. It is aimed to investigate the preservation mechanisms of substance addiction and therefore to bring a novel sight to the substance addiction issue with this study.

Kaynakça

  • Adinoff, B. (2004) “Neurobiologic Processes in Drug Reward and Addiction.” Harvard Review of Psychiatry, 12(6), 305–320.
  • Alcaro A, Huber R, Panksepp J. (2007) “Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective.” Brain Res Rev 2007; 56: 283– 321 .
  • Bunney BS, Aghajanian GK. (1978) “d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway.” NaunynSchmiedebergs Arch Pharmacol 1978;304:255–61.
  • Charles Darwin, "On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life," 1859.
  • Cooper ML, Frone MR, Russell M, Mudar P (1995) “Drinking to regulate positive and negative emotions: a motivational model of alcohol use.” J Pers Soc Psychol 1995, 69:990-1005.
  • Dalton, D. R. (1979) “The Alkaloids: The Fundamental Chemistry— A Biogenetic Approach.” New York: Marcel Dekker, Inc.
  • Di Chiara G.(1997) “Alcohol and dopamine.” Alcohol Health Res World 21:108–14.
  • Di Chiara G. (1998) “A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use.” J Psychopharmacol 1998;12:54–67.
  • Due DL, Huettel SA, Hall WG, Rubin DC. (2002) “Activation in mesolimbic and visuospatial neural circuits elicited by smoking cues: evidence from functional magnetic resonance imaging.” Am J Psychiatry 2002;159:954–60.
  • Glocker ML, Langleben DD, Ruparel K et al. (2009) “Baby schema modulates brain reward system in nulliparous women.” Proc Natl Acad Sci 2009; 106: 9115– 9119 .
  • Glover, I. C. (1971) “Prehistoric research in Timor.” In: Mulvaney, D. J. & Golson, J., eds. Aboriginal Man and Environment in Australia, pp. 158–181. Canberra: Australian National University Press.
  • Glover, I. C. (1977) “Prehistoric plant remains from Southeast Asia, with special reference to rice.” In: Taddei, M., ed. South Asian Archaeology, pp. 7–37. Naples: Istituto Universitario Orientale
  • Gorman, C. F. (1970) “Excavations at spirit cave, North Thailand: some interim interpretations.” Asian Perspectives, 13, 79–108.Grant S, London ED, Newlin DB, et al. (1996) “Activation of memory circuits during cue-elicited cocaine craving.” Proc Natl Acad Sci US A 1996;93:12040–5.
  • Jentsch JD, Taylor JR. (1999) “Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.” Psychopharmacology (Berl) 146:373–90.
  • Johns, T. (1990) “With Bitter Herbs They Shall Eat It: Chemical Ecology and the Origins of Human Diet and Medicine.” Tucson, AZ: The University of Arizona Press.
  • Kelley AE. (2004) “Memory and addiction: shared neural circuitry and molecular mechanisms.” Neuron 2004; 44: 161– 179 .
  • Kelley AE, Berridge KC. (2002) “The neuroscience of natural rewards: relevance to addictive drugs.” J Neurosci 2002; 22: 3306– 3311.
  • Moerman, D. E. (1994) “North American food and drug plants.” In: Etkin, N. L., ed. Eating on the Wild Side, pp. 166–181. Tucson: The University of Arizona Press
  • Pabba, M. (2013). “ Evolutionary development of the amygdaloid complex.” Frontiers in Neuroanatomy, 7, 27.
  • Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. (1987) “Cocaine receptors on dopamine transporters are related to self-administration of cocaine.” Science 1987;237:1219–23.
  • Sullivan, R. J., Allen, J. S., Otto, C., Tiobech, S. & Nero, K. (2000) “The effects of chewing betel nut (Areca catechu) on the symptoms of people with schizophrenia in Palau, Micronesia.” British Journal of Psychiatry, 177, 174–178.
  • Sullivan RJ, Hagen EH (2002) “Psychotropic substance-seeking: evolutionary pathology or adaptation?” Addiction 2002, 97:389-400.
  • Tammy Saah (2005) “The evolutionary origins and significance of drug addiction.” Harm Reduction Journal 2:8
  • Waterman, P. G. (1998) “Chemical taxonomy of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 87–107. New York: Plenum Press.
  • Wink, M. (1993) “Allelochemical properties or the raison d’être of alkaloids.” In: Cordell, G., ed. Alkaloids, pp. 1–118. San Diego: Academic Press.
  • Wink, M. (1998a) “Chemical ecology of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 265–300. New York: Plenum Press.
  • Wink, M. (1998b) “Modes of action of alkaloids.” In: Roberts, M. F. & Wink, M., eds. Alkaloids: Biochemistry, Ecology, and Medicinal Applications, pp. 301–326. New York: Plenum Press.
  • Yen, D. E. (1977) “Hoabinhian horticulture? The evidence and the questions from Northwest Thailand.” In: Allen, J., Golson, J. & Jones, R., eds. Sunda and Sahel, pp. 567–600. New York: Academic Press.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derleme
Yazarlar

Elif Mutlu

Yayımlanma Tarihi 31 Mart 2018
Kabul Tarihi 1 Nisan 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 19 Sayı: 1

Kaynak Göster

AMA Mutlu E. Madde Bağımlılığı ve İnsan Evrimi. Bağımlılık Dergisi. Mart 2018;19(1):17-22.

Bağımlılık Dergisi - Journal of Dependence