Araştırma Makalesi
NÖTROFİL/LENFOSİT VE PLATELET/LENFOSİT ORANLARI AZOOSPERMİ VE ANORMAL SPERM PARAMETRELERİ İÇİN PREDİKTİF MARKER OLARAK KULLANILABİLİR Mİ?
Öz
ÖZET
Amaç: Erkek
faktörlü infertilite toplunda sık karşılaşılan bir durumdur. Bu çalışmada
amacımız basit ve ucuz bir tetkik olan tam kan sayımı parametrelerini
kullanarak, pro-inflamatuar belirteçler olan nötrofil/lenfosit ve platelet/lenfosit
oranlarının, azoospermi, oligoastenozoospermi ve normal sperm parametrelerinde
prediktif olarak kullanılabilirliğini araştırmaktır.
Materyal ve Metod: Kliniğimize
erkek faktörlü infertilite araştırılması nedeniyle başvurmuş ve çalışma
kriterlerini sağlayan 358 hastanın kayıtları retrospektif olarak
incelendi. Hastalar Azoospermi grubu
(Grup 1), Oligoastenoteratozoospermi grubu (Grup 2), Normal sperm
parametrelerine sahip grup (Grup 3) olmak üzere üç gruba ayrıldı. Gruplar nötrofil,
lenfosit, platelet değerleri ile nötrofil/lenfosit oranı ve platelet/lenfosit
oranları açısından karşılaştırıldı.
Bulgular: Demografik
veriler ile nötrofil, lenfosit ve platelet değerleri açısından gruplar arası
anlamlı fark saptanmadı. Nötrofil/Lenfosit oranı ve Platelet/Lenfosit
oranı açısından istatistiksel anlamlı fark yoktu (sırasıyala p: 0,745, p: 0,998).
Sonuç: Azospermi
ve oligoastenoteratozoospermi olasılığını öngörebilmek için NLO ve PLO
değerlerini prediktif bir marker olarak kullanılmasını önermiyoruz.
Anahtar Kelimeler
Kaynakça
- Referans1- Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. Guidelines on Male Infertility (EAU). 2018.
- Referans2- Azenabor A, Ekun AO, Akinloye O. Impact of Inflammation on Male Reproductive Tract. J Reprod Infertil. 2015;16(3):123-129.
- Referans3- Hamada A, Esteves SC, Nizza M, Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol 2012;38:576-94
- Referans4- Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H et al. Evaluation of Neuthrophil-Lymphocyte Ratio, Platelet- Lymphocyte Ratio, Red Blood Cell Distrubution Widht-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. Journal of Family and Reproductive Health. 2016;10(4):211-16
- Referans5- Weidner, W, Pilatz, A, Diemer, T, Schuppe, H. C, Rusz, A, Wagenlehner, F. Male urogenital infections: Impact of infection and inflammation on ejaculate parameters. World Journal of Urology 2013;31:717–23.
- Referans6- Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am. 2002;29(4):817-27.
- Referans7- Güneş M, Umul M, Altok M, Akyuz M, İşoğlu CS, Uruc F, et al. Predictive role of hematologic parameters in testicular torsion. Korean J Urol 2015;56:324–29.
- Referans8- Kaya H, Ertas F, Islamoglu Y, Kaya Z, Atılgan ZA, Cil H, et al.. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clinical and Applied Thrombosis/Hemostasis 2012;20(1):50–4.
- Referans9- Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. (2012) Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012; 26;5(1):2.
- Referans10- Guthrie, GJ, Charles, KA, Roxburgh, CS, Horgan, PG, McMillan, DC, Clarke, SJ. The systemic inflammation‐based neutrophil‐lymphocyte ratio: Experience in patients with cancer. Critical Reviews in Oncology Hematology 2013;88(1):218-30.
- Referans11- Muratoglu M, Kayipmaz AE, Kavalci C, Kirnap M, Moray G, Haberal M. Platelet-to-Lymphocyte Ratio as a Potential Indicator of Infection-Associated Emergency Visits of Renal Transplant Recipients. Exp Clin Transplant. 2019 Apr 9. doi: 10.6002/ect.2018.0249. [Epub ahead of print]
- Referans12- Sambel M, Kilic M, Demirbas M, Onen E, Oner S, Erdogan A, et al. Relationship between erectile dysfunction and the neutrophil to lymphocyte and platelet to lymphocyte ratios. Int J Impot Res. 2018;30(1):27-35.
- Referans13- Orak M, Karakoc Y, Ustundag M, Yildirim Y, Celen MK, Guloglu C. An investigation of the effects of the mean platelet volume, platelet distribution width, platelet/lymphocyte ratio, and platelet counts on mortality in patents with sepsis who applied to the emergency department. Niger J Clin Pract. 2018;21(5):667-71.
- Referans14- World Health organization: Laboratory manual for the examination and processing of human semen, 5th ed. Geneva: WHO Press, 2010.
- Referans15- Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V,et al. Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice? Hum Reprod Update. 2018;24(4):416-41.
- Referans16- Hedger MP. Testicular leukocytes: what are they doing? Rev Reprod. 1997;2(1):38-47.
- Referans17- Bachir BG, Jarvi K. Infectious, inflammatory, and immunologic conditions resulting in male infertility. Urol Clin North Am. 2014;41(1):67-81.
- Referans18- Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H, et al. Evaluation of Neuthrophil-Lymphocyte Ratio, Platelet- Lymphocyte Ratio, Red Blood Cell Distrubution Widht-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. Journal of Family and Reproductive Health. 2016;10(4):211-16
- Referans19- Can E, Hamilcikan Ş, Can C. The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. J Pediatr Hematol Oncol.2018;40(4):229-32.
- Referans20- Wu S, Wan Q, Xu R, Zhu X, He H, Zhao X. Systematic review and meta-analysis of the prognostic value of preoperative platelet-tolymphocyte ratio in patients with urothelial carcinoma. Oncotarget. 2017;8(53):91694-702.
- Referans21- Yucel C, Keskin MZ, Cakmak O, Ergani B, Kose C, Celik O, et al. Predictive value of pre-operative inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-eosinophil ratio) in testicular sperm extraction: a pilot study. Andrology. 2017;5(6):1100-04.
- Referans22- Aykan S, Canat L, Gönültaş S, Atalay HA, Altunrende F. Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio? World J Mens Health. 2017;35(1):51-56.
- Referans23- Ates E, Ucar M, Keskin MZ, Gokce A. Preoperative neutrophil-to-lymphocyte ratio as a new prognostic predictor after microsurgical subinguinal varicocelectomy. Andrologia. 2019;51(2):e13188. doi: 10.1111/and.13188.
- Referans24- Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014;4:4260. doi: 10.1038/srep04260.
- Referans25- Lampiao F, du Plessis SS. TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online. 2008;17(5):628-31.
- Referans26- Zalata A, Atwa A, El-Naser Badawy A, Aziz A, El-Baz R, Elhanbly S, et al. Tumor necrosis factor-α gene polymorphism relationship to seminal variables in infertile men. Urology 2013;81:962-6.
IS IT POSSIBLE TO USE NEUTROFIL / LYMPHOCYTE AND PLATELET / LYMPHOCYTE RATIO AS A PREDICTIVE MARKER FOR AZOSPERMI AND ABNORMAL SEMEN PARAMETERS?
Öz
ABSTRACT
Purpose: Male
factor infertility is a common disease. In this study, we aimed to investigate
the predictability of neutrophil / lymphocyte and platelet / lymphocyte ratios
in azoospermic, oligoasthenozoospermic and normal semen parameters by using
whole blood count parameters which are simple and inexpensive.
Material and Methods: The
data of 358 patients who admitted to our clinic due to male factor infertility
were investigated retrospectively. The patients were divided into three groups
as azoospermia group (Group 1), oligoastenoteratozoospermia group (Group 2) and
normal group (Group 3). The groups were compared in terms of neutrophil,
lymphocyte, platelet values, neutrophil / lymphocyte ratio and platelet /
lymphocyte ratios.
Results: No
significant difference was found between the groups in terms of demographic
data, neutrophil, lymphocyte and platelet values. There was no statistically
significant difference in Neutrophil / Lymphocyte ratio and Platelet /
Lymphocyte ratio (p: 0.745, p: 0.998).
Conclusion: We
do not recommend the use of NLR and PLO to predict the probability of
azoospermia and oligoasthenoteratozoospermia.
Anahtar Kelimeler
Azoospermia; Neutrophil/Lymphocyte Ratio; Platelet/ Lymphocyte Ratio
Kaynakça
- Referans1- Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, Tournaye H. Guidelines on Male Infertility (EAU). 2018.
- Referans2- Azenabor A, Ekun AO, Akinloye O. Impact of Inflammation on Male Reproductive Tract. J Reprod Infertil. 2015;16(3):123-129.
- Referans3- Hamada A, Esteves SC, Nizza M, Agarwal A. Unexplained male infertility: diagnosis and management. Int Braz J Urol 2012;38:576-94
- Referans4- Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H et al. Evaluation of Neuthrophil-Lymphocyte Ratio, Platelet- Lymphocyte Ratio, Red Blood Cell Distrubution Widht-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. Journal of Family and Reproductive Health. 2016;10(4):211-16
- Referans5- Weidner, W, Pilatz, A, Diemer, T, Schuppe, H. C, Rusz, A, Wagenlehner, F. Male urogenital infections: Impact of infection and inflammation on ejaculate parameters. World Journal of Urology 2013;31:717–23.
- Referans6- Agarwal A, Saleh RA. Role of oxidants in male infertility: rationale, significance, and treatment. Urol Clin North Am. 2002;29(4):817-27.
- Referans7- Güneş M, Umul M, Altok M, Akyuz M, İşoğlu CS, Uruc F, et al. Predictive role of hematologic parameters in testicular torsion. Korean J Urol 2015;56:324–29.
- Referans8- Kaya H, Ertas F, Islamoglu Y, Kaya Z, Atılgan ZA, Cil H, et al.. Association between neutrophil to lymphocyte ratio and severity of coronary artery disease. Clinical and Applied Thrombosis/Hemostasis 2012;20(1):50–4.
- Referans9- Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. (2012) Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med 2012; 26;5(1):2.
- Referans10- Guthrie, GJ, Charles, KA, Roxburgh, CS, Horgan, PG, McMillan, DC, Clarke, SJ. The systemic inflammation‐based neutrophil‐lymphocyte ratio: Experience in patients with cancer. Critical Reviews in Oncology Hematology 2013;88(1):218-30.
- Referans11- Muratoglu M, Kayipmaz AE, Kavalci C, Kirnap M, Moray G, Haberal M. Platelet-to-Lymphocyte Ratio as a Potential Indicator of Infection-Associated Emergency Visits of Renal Transplant Recipients. Exp Clin Transplant. 2019 Apr 9. doi: 10.6002/ect.2018.0249. [Epub ahead of print]
- Referans12- Sambel M, Kilic M, Demirbas M, Onen E, Oner S, Erdogan A, et al. Relationship between erectile dysfunction and the neutrophil to lymphocyte and platelet to lymphocyte ratios. Int J Impot Res. 2018;30(1):27-35.
- Referans13- Orak M, Karakoc Y, Ustundag M, Yildirim Y, Celen MK, Guloglu C. An investigation of the effects of the mean platelet volume, platelet distribution width, platelet/lymphocyte ratio, and platelet counts on mortality in patents with sepsis who applied to the emergency department. Niger J Clin Pract. 2018;21(5):667-71.
- Referans14- World Health organization: Laboratory manual for the examination and processing of human semen, 5th ed. Geneva: WHO Press, 2010.
- Referans15- Fijak M, Pilatz A, Hedger MP, Nicolas N, Bhushan S, Michel V,et al. Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice? Hum Reprod Update. 2018;24(4):416-41.
- Referans16- Hedger MP. Testicular leukocytes: what are they doing? Rev Reprod. 1997;2(1):38-47.
- Referans17- Bachir BG, Jarvi K. Infectious, inflammatory, and immunologic conditions resulting in male infertility. Urol Clin North Am. 2014;41(1):67-81.
- Referans18- Ilhan G, Atmaca FFV, Altan E, Zebitay AG, Sozen H, Akyol H, et al. Evaluation of Neuthrophil-Lymphocyte Ratio, Platelet- Lymphocyte Ratio, Red Blood Cell Distrubution Widht-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency. Journal of Family and Reproductive Health. 2016;10(4):211-16
- Referans19- Can E, Hamilcikan Ş, Can C. The Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio for Detecting Early-onset Neonatal Sepsis. J Pediatr Hematol Oncol.2018;40(4):229-32.
- Referans20- Wu S, Wan Q, Xu R, Zhu X, He H, Zhao X. Systematic review and meta-analysis of the prognostic value of preoperative platelet-tolymphocyte ratio in patients with urothelial carcinoma. Oncotarget. 2017;8(53):91694-702.
- Referans21- Yucel C, Keskin MZ, Cakmak O, Ergani B, Kose C, Celik O, et al. Predictive value of pre-operative inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-eosinophil ratio) in testicular sperm extraction: a pilot study. Andrology. 2017;5(6):1100-04.
- Referans22- Aykan S, Canat L, Gönültaş S, Atalay HA, Altunrende F. Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio? World J Mens Health. 2017;35(1):51-56.
- Referans23- Ates E, Ucar M, Keskin MZ, Gokce A. Preoperative neutrophil-to-lymphocyte ratio as a new prognostic predictor after microsurgical subinguinal varicocelectomy. Andrologia. 2019;51(2):e13188. doi: 10.1111/and.13188.
- Referans24- Zhang H, Yin Y, Wang G, Liu Z, Liu L, Sun F. Interleukin-6 disrupts blood-testis barrier through inhibiting protein degradation or activating phosphorylated ERK in Sertoli cells. Sci Rep. 2014;4:4260. doi: 10.1038/srep04260.
- Referans25- Lampiao F, du Plessis SS. TNF-alpha and IL-6 affect human sperm function by elevating nitric oxide production. Reprod Biomed Online. 2008;17(5):628-31.
- Referans26- Zalata A, Atwa A, El-Naser Badawy A, Aziz A, El-Baz R, Elhanbly S, et al. Tumor necrosis factor-α gene polymorphism relationship to seminal variables in infertile men. Urology 2013;81:962-6.
Toplam 26 adet kaynakça vardır.
Kaynak Göster
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