Araştırma Makalesi
BibTex RIS Kaynak Göster

In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines

Yıl 2019, Cilt: 9 Sayı: 2, 549 - 571, 01.07.2019

Ayşe Tansu Koparal

https://doi.org/10.18039/ajesi.577253
Cited By: 10

Öz

The purpose of this
study is to investigate the effects of gilaburu juice on cell viability
(3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide, MTT) and
angiogenesis (tube formation assay) using different cell lines (human cancer
cell lines A549, Caco-2, HeLa and normal cell lines MDCK and HUVEC) in vitro.
In addition, the genotoxic effects of gilaburu juice is evaluated using COMET
assay on HUVEC cells. Our results demonstrate that gilaburu juice could inhibit
the growth of Caco-2 and HeLa cancer cell lines, but could not significantly
inhibit normal cell lines and A549 cancer cell lines. It disrupted tube
formation of HUVEC cells. Gilaburu juice appears to have no genotoxic potential
to the DNA of HUVEC cells. The results obtained in this study confirm the
potential application of commercial gilaburu juice as a functional food in
prevention of cancer.

Anahtar Kelimeler

Gilaburu juice European cranberry bush Viburnum opulus angiogenesis cancer

Teşekkür

The author thanks Edward Mcquaid for proofreading of the manuscript.

Kaynakça

  • Altun, L., & Yılmaz, B.S. (2007). HPLC method for the analysis of salicin and chlorogenic acid from Viburnum opulus and V.lantana. Chemistry of Natural Compounds, 43(2), 205-207.
  • Altun, M.L., Sever-Yılmaz. B., & Saltan-Çitoğlu, G. (2007). HPLC analysis of amentoflavone in Viburnum opulus L. and Viburnum lantana L. J. of Faculty of Pharmacy of Ankara University, 36, 161-169.
  • Ames, B.N. (1983). Dietary carcinogens and anticarcinogens. Science. 221, 1256–1264.
  • Bajpayee, M., Pandey, A.K., Parmar, D., Mathur, N., Seth, P.K., & Dhawan, A. (2005). Comet assay responses in human lymphocytes are not influenced by the menstrual cycle: a study in healty Indian females. Mutat. Res., 565, 163-172.
  • Calis, I., Yuruker, A., Ruegger, H., Wright, A.D., & Sticher, O. (1995). Lantanoside, a monocyclic C10 iridoid glucoside from Viburnum lantana. Phytochemistry, 38, 163–165.
  • Česonienė, L., Daubaras, R., & Viskelis, P.R. (2008). Evaluation of productivity and biochemical components in fruit of different Viburnum accessions. Biologia, 54,93-96.
  • Česonienė, L., Daubaras, R., Vencloviene, J., & Viškelis, P.R. (2010). Biochemical and agro-biological diversity of Viburnum opulus genotypes. Central European Journal of Biology, 6, 864–871.
  • Česonienė, L., Daubaras, R., Viškelis, P.R., & Sarkinas, A. (2012). Determination of the total phenolic and anthocyanin contents and antimicrobial activity of Viburnum opulus fruit juice. Plant Foods Human Nutrition, 67, 3, 256-261.
  • Česonienė, L., Daubaras, R., Kraujalytė, V., Venskutonis, P.R, & Šarkinas, A. (2014). Antimicrobial activity of Viburnum opulus fruit juices and extract. Journal für Verbraucherschutz und Lebensmittelsicherheit, 9, 129-132.
  • Chan, K., Wong, S.H., Wong, D.L.Y., Ho, W.Y., Chan, L.C, & Wong, R.N.S. (2009). Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sciences, 75, 3157-3171.
  • Chen, C.M., Li, S.C., Chen, C.Y.O., Au, H.K., Shih, C.K., Hsu, C.Y. & Liu, J.F. (2011). Constituents in purple sweet potato leaves inhibit in vitro angiogenesis with opposite effects ex vivo. Nutrition, 27, 1177-1182.
  • Ding, M., Feng, R., Wang, S.Y., Bowman, L., Lu, Y., Qian, Y., Castranova, V., Jiang, B.H., Shi, X. (2006). Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J. Biol. Chem., 281, 17359–17368.
  • Deineka, V.I., Sorokopudov, V.N., Deineka, L.A., Shaposhnik, E.I., & Kol’tsov, S.V. (2005). Anthocyans from fruit of some plants of the Caprifoliaceae family. Chemistry of Natural Compound, 41(2), 162-164.
  • Ersoy, N., Ercisli, S., Güündoğdu, M. (2017). Evaluation of European Cranberrybush (Viburnum opulus L.) genotypes for agro-morphological, biochemical and bioactive characteristics in Turkey. Folia Hortic, 29, 181-188.
  • Eryılmaz, M., Özbilgin, S., Ergene, B., Sever-Yılmaz, B., Altun, M.L., & Saltan, G. (2013). Antimicrobial activity of Turkish Viburnum species. Bagladesh J. Bot., 42(2), 355-360 (Short Communication).
  • Favot, L., Martin, S., Keravis, T., Andriantsitohaina, R., & Lugnier, C. (2003). Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc. Res., 59, 479–487.
  • Felter, H.W., Loyd, J.U. (2004) Viburnum opulus (U.S.P.) – Viburnum opulus. http://www.henriettes-herb.com/eclectic/kings/viburnum-opul.html Accessed 25 January 2005.
  • Folkman, J. (2003). Angiogenesis and apoptosis. Seminars in Cancer Bio., 13, 159-167.
  • Franke, S.I.R., Ckless, K., Silveira, J.D., Rubensam, G., Brendel, M., Erdtmann, B., & Henriques, J.A.P. (2004). Study of antioxidant and mutagenic activity of different orange juices. Food Chem, 88, 45-55.
  • Fukuyama, Y., Minoshima, Y., & Kishimoto, Y. (2005). Cytotoxic iridoid aldehydes from Taiwanese Viburnum luzonicum. Chemical and Pharmeceutical Bulletin, 53, 125-127.
  • Jang, I.C., Park, J.H., Park, E., Park, H.R., & Lee, S.C. (2008). Antioxidative and Antigenotoxic Activity of Extracts from Cosmos (Cosmos bipinnatus) Flowers. Plant Foods Hum. Nutr., 63, 205-210.
  • Karaçelik, A.A., Küçük, M., İskefiyeli, Z., Aydemir, S., Seppe, D.S., Miserez, B., & Sandra, P. (2015). Antioxidant components of Viburnum opulus L. determinated by on-line HPLC-Uv-ABTS radical scavenging and LC-UV-ESI-MS methods. Food Chemistry, 175, 106-114.
  • Khazir, J., Hyder, I., Gayatri, J.L., Yandrati, L.P., Nalla, N., Chasoo, G., Mahajan, A., Saxena, A.K., Alam, M.S., Quazi, G.N. & Kumar, H.M.S. (2014). Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds. European Journal of Medicinal Chemistry, 82, 255-262.
  • Koparal, A.T., Ulus, G., Zeytinoglu, M., Tay, T., & Turk, A.O. (2010). Angiogenesis inhibition by a lichen compound olivetoric acid. Phytotherapy Research, 24, 754-758.
  • Kraujalytė, V., Leitner, E., & Venskutonis, P.R. (2012). Chemical and sensory characterisation of aroma of Viburnum opulus fruits by solid phase microextraction-gas chromatography–olfactometry. Food Chemistry, 132, 717-723.
  • Kraujalytė, V., Venskutonis, P.R., Česonienė, L., & Daubaras, R. (2013). Antioxidant properties and polyphenolic compositions of fruits from different European cranberrybush (Viburnum opulus L.) genotypes. Food Chem, 141(4), 695-702.
  • Lim, S.W., Ting, K.N., Bradshaw, T.D., Zeenathul, N.A., Wiart, C., Khoo, T.J., Lim, K.H., & Loh, K.S. (2011). Acalpha wilkesiana extracts induce apoptosisby causing single strand and double strand DNA breaks. Journal of Ethnopharmacology, 138, 616-623.
  • Middleton, J.E., Kandaswami, C., & Theoharides, T.C. (2000). The effects of plant flavanoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 52, 673–751.
  • Moldovan, B., David, L., Chişbora, C., & Cimpoiu, C. (2012). Degradation kinetics of anthocyanins from European Cranberrybush (Viburnum opulus L.) fruit extracts. Molecules, 17, 11655-11666.
  • Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application proliferation and cytotoxicity assay. J.Immunol. Methods, 65, 55-63.
  • Nizamutdinova, I.T., Young, M.K., Chung, J.I.I., Shin, S.C., Jeong, Y., Seo, H.G. Lee, J.H., Chang, K.C., & Kim, H.J. (2009). Anthocyanins from black soybean seed coats stimulate wound healing in fibroblast and keratinocytes and prevent inflammation in endothelial cells. Food and Chemical Toxicology, 47, 2806-2812.
  • Olthof, M.R., Hollman, P.C.H., & Katan, M.B. (2001). Chlorogenic acid and caffeic acid are absorbed in humans. Journal of Nutrition, 131, 66-71.
  • Quchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K.J. (2004). Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells. Biol. Chem, 274, 1304-1309.
  • Rop, O., Reznicek, V., Valsikova, M., Jurikova, T., Mlcek, J., & Kramarova, D. (2010). Antioxidant properties of european cranberrybush fruit (Viburnum opulus var. edule). Molecules, 15, 4467–4477.
  • Sagdic, O., Aksoy, O., & Ozkan, G. (2006). Evaluation of the antibacterial and antioxidant potentials of cranberry (gilaburu, Viburnum opulus L.) fruit extract. Acta Aliment, Hung, 35, 487-492.
  • Sagdic, O., Ozturk, I., Yapar, N., & Yetim, H. (2014). Diversity and probiotic potentials of lactic acid bacteria isolated from gilaburu, a traditional Turkish fermented European cranberrybush (Viburnum Opulus L.) fruit drink. Food research International, 64, 537-545.
  • Sarıozkan, S., Türk, G., Eken, A., Bayram, L.Ç., Baldemir, A., Dogan, G. (2017). Gilaburu (Viburnum opulus L.) fruit extract alleviates testis and sperm damages induced by taxane-based chemotherapeutics. Biomed Pharmacother, 95, 1284-1294.
  • Sever-Yılmaz, B., Altun, M.L., Orhan-Erdoğan, İ., & Saltan-Çitoğlu, G. (2013). Enzyme inhibitory and antioxidant activities of Viburnum tinus L. Relevant to its neuroprotective potential. Food Chemistry., 141, 582-588.
  • Shen, Y.C., Lin, C.L., Chien, S.C., Khalil, A.T., Ko, C.L., & Wang, C.H. (2004). Vibsane diterpenoids from the leaves and flowers of Viburnum odoratissimum. Journal of Natural Products, 67, 74-77.
  • Shi, H., Dong, L., Jiang, J., Zhao, J., Zhao, G., Dang, X., Lu, X., & Jia, M. (2013). Chlorogenic acid reduced liver inflammation and fibrosis through inhibition of toll-like receptor 4 singaling pathway. Toxicology, 303, 107-114.
  • Singh, N.P., Mccoy, M.T., Tice, R.R., & Schneider, E.L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp.Cell Res, 175, 184-191.
  • Soylak, M., Elci, L., Saracoglu, S., & Divrikli, U. (2002). Chemical analysis of fruit juice of European cranberrybush (Viburnum opulus) from Kayseri-Turkey. Asian Journal of Chemistry, 14,135-138.
  • Stavric, B. (1994). Role of chemopreventers in human diet clinical. Biochem. 27, 319–332.
  • Ulger, H., Ertekin, T., Karaca, O., Canoz, O., Nisari, M., Unur, E., & Elmalı, F.(2013). Influence of gilaburu (Viburnum opulus) juice on 1,2-dimethylhydrazine (DMH)-induced colon cancer. Toxicology and Industry Health, 29(9), 824-829.
  • Van, Q., Nay, B.N., Reimer, M., Jones, P.J.H., Fulcher, R.G., & Rempel, C.B. (2009). Anti-inflamatory effect of Innotus obliquus, Polygala senega, and Viburnum trilobum in a cell screening assay. Journal of Ethnopharmacology, 3, 487-493.
  • Velioglu, Y.S., Ekici, L., & Poyrazoglu, E.S. (2006). Phenolic composition of European cranberrybush (Viburnum opulus L.) berries and astringency removal of its commercial juice. International Journal of Food Science and Technology, 41, 1011–1015.
  • Wang, G.F., Shi, L.P., Ren, Y.D., Liu, Q.F., Liu, H.F., Zhang, R.J., Li, Z., Zhu, F.H., He, P.L., Tang, W., Tao, P.Z., Li, C., Zhao, W.M., & Zuo, J.P. (2009). Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research, 83(2), 186-190.
  • Waheed, A., Bibi, Y., Nisa, S., Chaudhary, F.M., Sahreen, S., & Zia, M. (2013). Inhibition of human breast and colorectal cancer cells by Viburnum foetens L. extracts in vitro. Asian Pasific Journal of Tropical Disease, 3(1), 32-36.
  • Zayachkivska, O.S., Gzegotsky, M.R., Terletska, O.I., Lutsyk, D.A., Yaschenko, A.M., & Dzhura, O.R. (2006). Influence of Viburnum opulus proanthocyanins on stres induced gastrointestinal mucosal damage. J. Physiol Pharmacol. 57(5), 155-167.
  • Zhao, C., Giusti, M.M., Malik, M., Moyer, M.P., & Magnuson, B.A. (2004). Effects of commercial anthocyanin –rich extract on coonic cancer and non tumorogenic colonic cell growth. Journal of Agricultural and Food Chemistry, 52, 6122-6128.

Yıl 2019, Cilt: 9 Sayı: 2, 549 - 571, 01.07.2019

Ayşe Tansu Koparal

https://doi.org/10.18039/ajesi.577253
Cited By: 10

Öz

Kaynakça

  • Altun, L., & Yılmaz, B.S. (2007). HPLC method for the analysis of salicin and chlorogenic acid from Viburnum opulus and V.lantana. Chemistry of Natural Compounds, 43(2), 205-207.
  • Altun, M.L., Sever-Yılmaz. B., & Saltan-Çitoğlu, G. (2007). HPLC analysis of amentoflavone in Viburnum opulus L. and Viburnum lantana L. J. of Faculty of Pharmacy of Ankara University, 36, 161-169.
  • Ames, B.N. (1983). Dietary carcinogens and anticarcinogens. Science. 221, 1256–1264.
  • Bajpayee, M., Pandey, A.K., Parmar, D., Mathur, N., Seth, P.K., & Dhawan, A. (2005). Comet assay responses in human lymphocytes are not influenced by the menstrual cycle: a study in healty Indian females. Mutat. Res., 565, 163-172.
  • Calis, I., Yuruker, A., Ruegger, H., Wright, A.D., & Sticher, O. (1995). Lantanoside, a monocyclic C10 iridoid glucoside from Viburnum lantana. Phytochemistry, 38, 163–165.
  • Česonienė, L., Daubaras, R., & Viskelis, P.R. (2008). Evaluation of productivity and biochemical components in fruit of different Viburnum accessions. Biologia, 54,93-96.
  • Česonienė, L., Daubaras, R., Vencloviene, J., & Viškelis, P.R. (2010). Biochemical and agro-biological diversity of Viburnum opulus genotypes. Central European Journal of Biology, 6, 864–871.
  • Česonienė, L., Daubaras, R., Viškelis, P.R., & Sarkinas, A. (2012). Determination of the total phenolic and anthocyanin contents and antimicrobial activity of Viburnum opulus fruit juice. Plant Foods Human Nutrition, 67, 3, 256-261.
  • Česonienė, L., Daubaras, R., Kraujalytė, V., Venskutonis, P.R, & Šarkinas, A. (2014). Antimicrobial activity of Viburnum opulus fruit juices and extract. Journal für Verbraucherschutz und Lebensmittelsicherheit, 9, 129-132.
  • Chan, K., Wong, S.H., Wong, D.L.Y., Ho, W.Y., Chan, L.C, & Wong, R.N.S. (2009). Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunction. Life Sciences, 75, 3157-3171.
  • Chen, C.M., Li, S.C., Chen, C.Y.O., Au, H.K., Shih, C.K., Hsu, C.Y. & Liu, J.F. (2011). Constituents in purple sweet potato leaves inhibit in vitro angiogenesis with opposite effects ex vivo. Nutrition, 27, 1177-1182.
  • Ding, M., Feng, R., Wang, S.Y., Bowman, L., Lu, Y., Qian, Y., Castranova, V., Jiang, B.H., Shi, X. (2006). Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J. Biol. Chem., 281, 17359–17368.
  • Deineka, V.I., Sorokopudov, V.N., Deineka, L.A., Shaposhnik, E.I., & Kol’tsov, S.V. (2005). Anthocyans from fruit of some plants of the Caprifoliaceae family. Chemistry of Natural Compound, 41(2), 162-164.
  • Ersoy, N., Ercisli, S., Güündoğdu, M. (2017). Evaluation of European Cranberrybush (Viburnum opulus L.) genotypes for agro-morphological, biochemical and bioactive characteristics in Turkey. Folia Hortic, 29, 181-188.
  • Eryılmaz, M., Özbilgin, S., Ergene, B., Sever-Yılmaz, B., Altun, M.L., & Saltan, G. (2013). Antimicrobial activity of Turkish Viburnum species. Bagladesh J. Bot., 42(2), 355-360 (Short Communication).
  • Favot, L., Martin, S., Keravis, T., Andriantsitohaina, R., & Lugnier, C. (2003). Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc. Res., 59, 479–487.
  • Felter, H.W., Loyd, J.U. (2004) Viburnum opulus (U.S.P.) – Viburnum opulus. http://www.henriettes-herb.com/eclectic/kings/viburnum-opul.html Accessed 25 January 2005.
  • Folkman, J. (2003). Angiogenesis and apoptosis. Seminars in Cancer Bio., 13, 159-167.
  • Franke, S.I.R., Ckless, K., Silveira, J.D., Rubensam, G., Brendel, M., Erdtmann, B., & Henriques, J.A.P. (2004). Study of antioxidant and mutagenic activity of different orange juices. Food Chem, 88, 45-55.
  • Fukuyama, Y., Minoshima, Y., & Kishimoto, Y. (2005). Cytotoxic iridoid aldehydes from Taiwanese Viburnum luzonicum. Chemical and Pharmeceutical Bulletin, 53, 125-127.
  • Jang, I.C., Park, J.H., Park, E., Park, H.R., & Lee, S.C. (2008). Antioxidative and Antigenotoxic Activity of Extracts from Cosmos (Cosmos bipinnatus) Flowers. Plant Foods Hum. Nutr., 63, 205-210.
  • Karaçelik, A.A., Küçük, M., İskefiyeli, Z., Aydemir, S., Seppe, D.S., Miserez, B., & Sandra, P. (2015). Antioxidant components of Viburnum opulus L. determinated by on-line HPLC-Uv-ABTS radical scavenging and LC-UV-ESI-MS methods. Food Chemistry, 175, 106-114.
  • Khazir, J., Hyder, I., Gayatri, J.L., Yandrati, L.P., Nalla, N., Chasoo, G., Mahajan, A., Saxena, A.K., Alam, M.S., Quazi, G.N. & Kumar, H.M.S. (2014). Design and synthesis of novel 1,2,3-triazole derivatives of coronopilin as anti-cancer compounds. European Journal of Medicinal Chemistry, 82, 255-262.
  • Koparal, A.T., Ulus, G., Zeytinoglu, M., Tay, T., & Turk, A.O. (2010). Angiogenesis inhibition by a lichen compound olivetoric acid. Phytotherapy Research, 24, 754-758.
  • Kraujalytė, V., Leitner, E., & Venskutonis, P.R. (2012). Chemical and sensory characterisation of aroma of Viburnum opulus fruits by solid phase microextraction-gas chromatography–olfactometry. Food Chemistry, 132, 717-723.
  • Kraujalytė, V., Venskutonis, P.R., Česonienė, L., & Daubaras, R. (2013). Antioxidant properties and polyphenolic compositions of fruits from different European cranberrybush (Viburnum opulus L.) genotypes. Food Chem, 141(4), 695-702.
  • Lim, S.W., Ting, K.N., Bradshaw, T.D., Zeenathul, N.A., Wiart, C., Khoo, T.J., Lim, K.H., & Loh, K.S. (2011). Acalpha wilkesiana extracts induce apoptosisby causing single strand and double strand DNA breaks. Journal of Ethnopharmacology, 138, 616-623.
  • Middleton, J.E., Kandaswami, C., & Theoharides, T.C. (2000). The effects of plant flavanoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 52, 673–751.
  • Moldovan, B., David, L., Chişbora, C., & Cimpoiu, C. (2012). Degradation kinetics of anthocyanins from European Cranberrybush (Viburnum opulus L.) fruit extracts. Molecules, 17, 11655-11666.
  • Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application proliferation and cytotoxicity assay. J.Immunol. Methods, 65, 55-63.
  • Nizamutdinova, I.T., Young, M.K., Chung, J.I.I., Shin, S.C., Jeong, Y., Seo, H.G. Lee, J.H., Chang, K.C., & Kim, H.J. (2009). Anthocyanins from black soybean seed coats stimulate wound healing in fibroblast and keratinocytes and prevent inflammation in endothelial cells. Food and Chemical Toxicology, 47, 2806-2812.
  • Olthof, M.R., Hollman, P.C.H., & Katan, M.B. (2001). Chlorogenic acid and caffeic acid are absorbed in humans. Journal of Nutrition, 131, 66-71.
  • Quchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., & Walsh, K.J. (2004). Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells. Biol. Chem, 274, 1304-1309.
  • Rop, O., Reznicek, V., Valsikova, M., Jurikova, T., Mlcek, J., & Kramarova, D. (2010). Antioxidant properties of european cranberrybush fruit (Viburnum opulus var. edule). Molecules, 15, 4467–4477.
  • Sagdic, O., Aksoy, O., & Ozkan, G. (2006). Evaluation of the antibacterial and antioxidant potentials of cranberry (gilaburu, Viburnum opulus L.) fruit extract. Acta Aliment, Hung, 35, 487-492.
  • Sagdic, O., Ozturk, I., Yapar, N., & Yetim, H. (2014). Diversity and probiotic potentials of lactic acid bacteria isolated from gilaburu, a traditional Turkish fermented European cranberrybush (Viburnum Opulus L.) fruit drink. Food research International, 64, 537-545.
  • Sarıozkan, S., Türk, G., Eken, A., Bayram, L.Ç., Baldemir, A., Dogan, G. (2017). Gilaburu (Viburnum opulus L.) fruit extract alleviates testis and sperm damages induced by taxane-based chemotherapeutics. Biomed Pharmacother, 95, 1284-1294.
  • Sever-Yılmaz, B., Altun, M.L., Orhan-Erdoğan, İ., & Saltan-Çitoğlu, G. (2013). Enzyme inhibitory and antioxidant activities of Viburnum tinus L. Relevant to its neuroprotective potential. Food Chemistry., 141, 582-588.
  • Shen, Y.C., Lin, C.L., Chien, S.C., Khalil, A.T., Ko, C.L., & Wang, C.H. (2004). Vibsane diterpenoids from the leaves and flowers of Viburnum odoratissimum. Journal of Natural Products, 67, 74-77.
  • Shi, H., Dong, L., Jiang, J., Zhao, J., Zhao, G., Dang, X., Lu, X., & Jia, M. (2013). Chlorogenic acid reduced liver inflammation and fibrosis through inhibition of toll-like receptor 4 singaling pathway. Toxicology, 303, 107-114.
  • Singh, N.P., Mccoy, M.T., Tice, R.R., & Schneider, E.L. (1988). A simple technique for quantitation of low levels of DNA damage in individual cells. Exp.Cell Res, 175, 184-191.
  • Soylak, M., Elci, L., Saracoglu, S., & Divrikli, U. (2002). Chemical analysis of fruit juice of European cranberrybush (Viburnum opulus) from Kayseri-Turkey. Asian Journal of Chemistry, 14,135-138.
  • Stavric, B. (1994). Role of chemopreventers in human diet clinical. Biochem. 27, 319–332.
  • Ulger, H., Ertekin, T., Karaca, O., Canoz, O., Nisari, M., Unur, E., & Elmalı, F.(2013). Influence of gilaburu (Viburnum opulus) juice on 1,2-dimethylhydrazine (DMH)-induced colon cancer. Toxicology and Industry Health, 29(9), 824-829.
  • Van, Q., Nay, B.N., Reimer, M., Jones, P.J.H., Fulcher, R.G., & Rempel, C.B. (2009). Anti-inflamatory effect of Innotus obliquus, Polygala senega, and Viburnum trilobum in a cell screening assay. Journal of Ethnopharmacology, 3, 487-493.
  • Velioglu, Y.S., Ekici, L., & Poyrazoglu, E.S. (2006). Phenolic composition of European cranberrybush (Viburnum opulus L.) berries and astringency removal of its commercial juice. International Journal of Food Science and Technology, 41, 1011–1015.
  • Wang, G.F., Shi, L.P., Ren, Y.D., Liu, Q.F., Liu, H.F., Zhang, R.J., Li, Z., Zhu, F.H., He, P.L., Tang, W., Tao, P.Z., Li, C., Zhao, W.M., & Zuo, J.P. (2009). Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro. Antiviral Research, 83(2), 186-190.
  • Waheed, A., Bibi, Y., Nisa, S., Chaudhary, F.M., Sahreen, S., & Zia, M. (2013). Inhibition of human breast and colorectal cancer cells by Viburnum foetens L. extracts in vitro. Asian Pasific Journal of Tropical Disease, 3(1), 32-36.
  • Zayachkivska, O.S., Gzegotsky, M.R., Terletska, O.I., Lutsyk, D.A., Yaschenko, A.M., & Dzhura, O.R. (2006). Influence of Viburnum opulus proanthocyanins on stres induced gastrointestinal mucosal damage. J. Physiol Pharmacol. 57(5), 155-167.
  • Zhao, C., Giusti, M.M., Malik, M., Moyer, M.P., & Magnuson, B.A. (2004). Effects of commercial anthocyanin –rich extract on coonic cancer and non tumorogenic colonic cell growth. Journal of Agricultural and Food Chemistry, 52, 6122-6128.
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Ayşe Tansu Koparal Bu kişi benim 0000-0001-8201-6708

Yayımlanma Tarihi 1 Temmuz 2019
Gönderilme Tarihi 21 Şubat 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 9 Sayı: 2

Kaynak Göster

APA Koparal, A. T. (2019). In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines. Anadolu Journal of Educational Sciences International, 9(2), 549-571. https://doi.org/10.18039/ajesi.577253
AMA Koparal AT. In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines. AJESI. Temmuz 2019;9(2):549-571. doi:10.18039/ajesi.577253
Chicago Koparal, Ayşe Tansu. “In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines”. Anadolu Journal of Educational Sciences International 9, sy. 2 (Temmuz 2019): 549-71. https://doi.org/10.18039/ajesi.577253.
EndNote Koparal AT (01 Temmuz 2019) In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines. Anadolu Journal of Educational Sciences International 9 2 549–571.
IEEE A. T. Koparal, “In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines”, AJESI, c. 9, sy. 2, ss. 549–571, 2019, doi: 10.18039/ajesi.577253.
ISNAD Koparal, Ayşe Tansu. “In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines”. Anadolu Journal of Educational Sciences International 9/2 (Temmuz 2019), 549-571. https://doi.org/10.18039/ajesi.577253.
JAMA Koparal AT. In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines. AJESI. 2019;9:549–571.
MLA Koparal, Ayşe Tansu. “In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines”. Anadolu Journal of Educational Sciences International, c. 9, sy. 2, 2019, ss. 549-71, doi:10.18039/ajesi.577253.
Vancouver Koparal AT. In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines. AJESI. 2019;9(2):549-71.

Cited By

Extraction method affects seed oil yield, composition, and antioxidant properties of European cranberrybush (Viburnum opulus)
Industrial Crops and Products
https://doi.org/10.1016/j.indcrop.2021.113632
Importance of edible wild plants in world food security: The case of Turkey
International Journal of Agricultural Science and Food Technology
https://doi.org/10.17352/2455-815X.000165
Effects of Non-Thermal Treatment on Gilaburu Vinegar (Viburnum opulus L.): Polyphenols, Amino Acid, Antimicrobial, and Anticancer Properties
Biology
https://doi.org/10.3390/biology11060926
Valorization of European Cranberry Bush (Viburnum opulus L.) Berry Pomace Extracts Isolated with Pressurized Ethanol and Water by Assessing Their Phytochemical Composition, Antioxidant, and Antiproliferative Activities
Foods
Lijana Dienaitė
https://doi.org/10.3390/foods9101413
Organic cherry laurel ( Prunus laurocerasus ) vinegar enriched with bioactive compounds with ultrasound technology using artificial neural network (ANN) and response surface methodology (RSM): Antidiabetic, antihypertensive, cytotoxic activities, volatile profile and optical microstructure
Journal of Food Processing and Preservation
Seydi Yıkmış
https://doi.org/10.1111/jfpp.15883
Screening of different fruit extracts from Viburnum opulus L. as inhibitors of key enzymes linked to type 2 diabetes and antioxidants: a comparative evaluation
Journal of Food Measurement and Characterization
Leyla Paşayeva
https://doi.org/10.1007/s11694-021-01007-4
Potential probiotic lactic acid bacteria isolated from fermented gilaburu and shalgam beverages
LWT
Perihan Kubra Akman
https://doi.org/10.1016/j.lwt.2021.111705
Genus Viburnum: Therapeutic Potentialities and Agro-Food-Pharma Applications
Oxidative Medicine and Cellular Longevity
Javad Sharifi-Rad
https://doi.org/10.1155/2021/3095514
Viburnum opulus L.—A Review of Phytochemistry and Biological Effects
Nutrients
Dominika Kajszczak
https://doi.org/10.3390/nu12113398
Cytotoxic, genotoxic and apoptotic effects of Viburnum opulus on colon cancer cells: an in vitro study
Turkish Journal of Biochemistry
Kubra Bozali
https://doi.org/10.1515/tjb-2020-0182
 Kapak Resmi İndir

Creative Commons License
AJESI’de yayınlanan makalelerde bu lisans kullanılmaktadır.

Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Sherpa Romeo kayıtlıdır.