Öz
Amaç: D vitamini, bazı gıdalarda bulunan ve güneş ışığına maruz kalan öncülerinden sentezlenebilen yağda çözünen bir vitamindir. Serum 25-hidroksi vitamin D (25-OH Vit D) konsantrasyonunun Vitamin D seviyesinin en iyi göstergesi olduğu bilinmektedir. D vitamininin ana kaynağı güneş ışığına maruz kalan ciltten sentez edilmesidir. Çalışmada Van'da hastanemize başvuran hastaların D vitamini düzeylerini geriye yönelik taradık. 25-OH vit D düzeylerinin yaş, cinsiyet ve mevsimsel farklılıkları arasındaki ilişkiyi araştırdık.
Yöntem: Yüzüncü Yıl Üniversitesi Tıp Fakültesi Dursun Odabaş Tıp Merkezine başvuran 01.01.2013 - 01.01.2014 tarihleri arasında 25-OH vit D düzeyleri tespit edilen kriterleri sağlayan sonuçlar dahil edildi.
Bulgular: Erkeklerin yaş ortalaması (n = 306) 46.65 ± 16.62, kadınlarda (n = 1613) 43.58 ± 15.03 olarak bulundu. Erkeklerde ortalama 25-OH vit D 18.95 ± 7.93 ng / mL ve kadınlarda 14.79 ± 9.42 ng / ml olarak bulundu. Erkeklerin 25-OH D vitamini düzeyleri kadınlardan anlamlı derecede yüksek bulundu (p <0.05). Mevsime göre 25-OH D vitamini seviyeleri analiz edildiğinde, yaz mevsimi için 25-OH Vitamin D ortalaması kış mevsimine ya da Sonbahar-İlkbahar aylarına göre anlamlı olarak yüksekti (p = 0,006).
Sonuç: Her ne kadar Van, konumu itibariyle en çok güneş alan şehirler arasında olsa da, tüm mevsimler ve yaş gruplarına göre vitamin D düzeylerini düşük olduğunu düşünüyoruz. Bu bulgulara göre, Van ilindeki ve çevresindeki vitamin D eksikliğinin düzelmesi için hem beslenme desteğinin hem de D vitamini desteğinin önemli olduğu sonucuna vardık.
Anahtar Kelimeler
Kaynakça
- 1. Holick MF. Vitamin D deficiency. The New England journal of medicine. 2007 Jul 19;357(3):266-81. PMID: 17634462.
- 2. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Therapeutic advances in endocrinology and metabolism. 2013 Aug;4(4):122-8. PubMed PMID: 23997931. PMCID: 3755528.
- 3. Pilz S, Gaksch M, O'Hartaigh B, Tomaschitz A, Marz W. The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? Archives of toxicology. 2013 Dec;87(12):2083-103. PMID: 24173581.
- 4. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem. 2007 Mar;103(3-5):708-11. PMID: 17368188
- 5. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Jama-J Am Med Assoc. 2006 Dec 20;296(23):2832-8. PMID: 17179460
- 6. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics. 2005 Jan-Feb;40(1):53-60. PMID: 15531023.
- 7. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem 2010;121(1-2):297-300. PMID: 20197091
- 8. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72 ': evidence of deficiency. J Perinatol. 2007 Sep;27(9):568-71. PMID: 17625571
- 9. Huotari A, Herzig KH. Vitamin D and living in northern latitudes - An endemic risk area for vitamin D deficiency. Int J Circumpol Heal. 2008 Jun;67(2-3):164-78. PMID: 18767337
- 10. Aslan A, Karakoyun O, Güler E, Aydin S, Gök MV, Akkurt S. [Evaluation of bone mineral density, osteoporosis prevalence and regional risk factors in Turkish women living in Kastamonu: KASTÜRKOS study]. Eklem Hastalik Cerrahisi. 2012;23(2):62-7. Turkish. PMID: 22765482
- 11. Gülcü A, Özen Ö. The Bone Mineral Density Values of Women in Alanya and Regional Turkish Community: Cross-sectional Comparative Study. Acta Medica Alanya 2018;2(2):111-115. DOI:10.30565/medalanya.426939
- 12. EIE. Güneş enerjisi potansiyel atlası: Yenilenebilir Enerji Genel Müdürlüğü; 2014.
- 13. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001 Aug;22(4):477-501. PMID: 11493580
- 14. van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011 Aug;25(4):671-80. PMID: 21872807.
- 15. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC public health. 2004 Aug 25;4:38. PMID: 15327695.
- 16. Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Hormone research. 2005;64(3):144-8. PMID: 16192739.
- 17. Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. The American journal of clinical nutrition. 1983 Jul;38(1):129-32. PMID: 6602540.
- 18. Aspray TJ, Yan L, Prentice A. Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women. Bone. 2005 Apr;36(4):710-20. PMID: 15780975.
- 19. M'Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A. Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcified tissue international. 1987 Aug;41(2):70-4. PMID: 3115547.
- 20. Haarburger D, Hoffman M, Erasmus RT, Pillay TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol. 2009 Jun;62(6):567-9. PMID: 19213756
- 21. Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizleri H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest. 2000 Mar;23(3):173-7. PMID: 10803475
- 22. Joh H-K, Seung-sik H, Cho B, Lim CS, Jung S-E. Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial. Clinical Nutrition. 2019. DOI: 10.1016/j.clnu.2019.03.021
- 23. Pierret L, Suppa M, Gandini S, Del Marmol V, Gutermuth J. Overview on vitamin D and sunbed use. Journal of the European Academy of Dermatology and Venereology. 2019;33:28-33. DOI: 10.1111/jdv.15316.
- 24. Alamoudi LH, Almuteeri RZ, Al-Otaibi ME, Alshaer DA, Fatani SK, Alghamdi MM, et al. Awareness of Vitamin D Deficiency among the General Population in Jeddah, Saudi Arabia. Journal of Nutrition and Metabolism. 2019;2019. DOI: 10.1155/2019/4138187
Öz
Objectives:
Vitamin D is a fat-soluble vitamin which is found in certain foods and can be
synthesized from its precursors with exposure to sunlight. It is known that
serum 25-hydroxy vitamin D (25-OH Vit D) concentration is the best indicator of
Vitamin D level. Main source of Vitamin D is the synthesis to the skin with
sunlight exposure. In our study we investigated the vitamin D levels of
patients administered to our hospital in Van. We aimed to determine any
significant difference between age, sex and seasonal differences of the 25-OH
vit D levels.
Materials and Method: Patients
admitted to Yuzuncu Yil University Faculty of Medicine Dursun Odabas Medical
Hospital from 01.01.2013 to 01.01.2014 with 25-OH vit D levels were determined
and evaluated [JB1] respectively.
Results: Mean
age for males (n=306) was found as 46.65±16.62 and for females (n=1613) as
43.58±15.03. Mean 25-OH vit D in males was found as 18.95±7.93 ng/mL and in
females it was found as 14.79±9.42 ng/ml. 25-OH vit D levels of males were found
significantly higher than that of females (p<0.05). When 25-OH vit D levels
were analyzed according to season, a mean of 25-OH vit D for the summer season
was found significantly higher than those of the winter or autumn-spring months
(p=0.006). Although Van receives one of the highest amount of sunlight due to
its geographical position, we consider that there exists a deficiency in all
age groups in the society, for all seasons.
Conclusions:
According to these findings we conclude that both nutritional support and
Vitamin D supplementation is important for recovery of vitamin D deficiency in
and around the city of Van.
[JB1]Note
to Draft: unable to validate – please
clarify:
- Detemined could be Identified?
- Respectively: invidualy?
Unclear.
Anahtar Kelimeler
Kaynakça
- 1. Holick MF. Vitamin D deficiency. The New England journal of medicine. 2007 Jul 19;357(3):266-81. PMID: 17634462.
- 2. Kostoglou-Athanassiou I, Athanassiou P, Gkountouvas A, Kaldrymides P. Vitamin D and glycemic control in diabetes mellitus type 2. Therapeutic advances in endocrinology and metabolism. 2013 Aug;4(4):122-8. PubMed PMID: 23997931. PMCID: 3755528.
- 3. Pilz S, Gaksch M, O'Hartaigh B, Tomaschitz A, Marz W. The role of vitamin D deficiency in cardiovascular disease: where do we stand in 2013? Archives of toxicology. 2013 Dec;87(12):2083-103. PMID: 24173581.
- 4. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, et al. Vitamin D and prevention of breast cancer: Pooled analysis. J Steroid Biochem. 2007 Mar;103(3-5):708-11. PMID: 17368188
- 5. Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Jama-J Am Med Assoc. 2006 Dec 20;296(23):2832-8. PMID: 17179460
- 6. Atli T, Gullu S, Uysal AR, Erdogan G. The prevalence of Vitamin D deficiency and effects of ultraviolet light on Vitamin D levels in elderly Turkish population. Archives of gerontology and geriatrics. 2005 Jan-Feb;40(1):53-60. PMID: 15531023.
- 7. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem 2010;121(1-2):297-300. PMID: 20197091
- 8. Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32 degrees 72 ': evidence of deficiency. J Perinatol. 2007 Sep;27(9):568-71. PMID: 17625571
- 9. Huotari A, Herzig KH. Vitamin D and living in northern latitudes - An endemic risk area for vitamin D deficiency. Int J Circumpol Heal. 2008 Jun;67(2-3):164-78. PMID: 18767337
- 10. Aslan A, Karakoyun O, Güler E, Aydin S, Gök MV, Akkurt S. [Evaluation of bone mineral density, osteoporosis prevalence and regional risk factors in Turkish women living in Kastamonu: KASTÜRKOS study]. Eklem Hastalik Cerrahisi. 2012;23(2):62-7. Turkish. PMID: 22765482
- 11. Gülcü A, Özen Ö. The Bone Mineral Density Values of Women in Alanya and Regional Turkish Community: Cross-sectional Comparative Study. Acta Medica Alanya 2018;2(2):111-115. DOI:10.30565/medalanya.426939
- 12. EIE. Güneş enerjisi potansiyel atlası: Yenilenebilir Enerji Genel Müdürlüğü; 2014.
- 13. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001 Aug;22(4):477-501. PMID: 11493580
- 14. van Schoor NM, Lips P. Worldwide vitamin D status. Best practice & research Clinical endocrinology & metabolism. 2011 Aug;25(4):671-80. PMID: 21872807.
- 15. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC public health. 2004 Aug 25;4:38. PMID: 15327695.
- 16. Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Hormone research. 2005;64(3):144-8. PMID: 16192739.
- 17. Sedrani SH, Elidrissy AW, El Arabi KM. Sunlight and vitamin D status in normal Saudi subjects. The American journal of clinical nutrition. 1983 Jul;38(1):129-32. PMID: 6602540.
- 18. Aspray TJ, Yan L, Prentice A. Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women. Bone. 2005 Apr;36(4):710-20. PMID: 15780975.
- 19. M'Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A. Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcified tissue international. 1987 Aug;41(2):70-4. PMID: 3115547.
- 20. Haarburger D, Hoffman M, Erasmus RT, Pillay TS. Relationship between vitamin D, calcium and parathyroid hormone in Cape Town. J Clin Pathol. 2009 Jun;62(6):567-9. PMID: 19213756
- 21. Alagol F, Shihadeh Y, Boztepe H, Tanakol R, Yarman S, Azizleri H, et al. Sunlight exposure and vitamin D deficiency in Turkish women. J Endocrinol Invest. 2000 Mar;23(3):173-7. PMID: 10803475
- 22. Joh H-K, Seung-sik H, Cho B, Lim CS, Jung S-E. Effect of sun exposure versus oral vitamin D supplementation on serum 25-hydroxyvitamin D concentrations in young adults: A randomized clinical trial. Clinical Nutrition. 2019. DOI: 10.1016/j.clnu.2019.03.021
- 23. Pierret L, Suppa M, Gandini S, Del Marmol V, Gutermuth J. Overview on vitamin D and sunbed use. Journal of the European Academy of Dermatology and Venereology. 2019;33:28-33. DOI: 10.1111/jdv.15316.
- 24. Alamoudi LH, Almuteeri RZ, Al-Otaibi ME, Alshaer DA, Fatani SK, Alghamdi MM, et al. Awareness of Vitamin D Deficiency among the General Population in Jeddah, Saudi Arabia. Journal of Nutrition and Metabolism. 2019;2019. DOI: 10.1155/2019/4138187
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 23 Ağustos 2019 |
| Gönderilme Tarihi | 26 Eylül 2018 |
| Kabul Tarihi | 17 Ağustos 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 3 Sayı: 2 |
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