Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

Cagatay Oltulu; Tugce Yesil Devecioglu; Melek Akinci; Sevcan Gul Akgun Olmez; Serra Vildan Obeidin; Ayfer Beceren

doi:10.33808/clinexphealthsci.563988

Araştırma Makalesi

Yıl 2019, Cilt: 9 Sayı: 2, 166 - 170, 30.06.2019

Cagatay Oltulu Tugce Yesil Devecioglu Melek Akinci Sevcan Gul Akgun Olmez Serra Vildan Obeidin Ayfer Beceren

https://doi.org/10.33808/clinexphealthsci.563988

Cited By: 3

Öz

Kaynakça

1. El-Ebiary AA, Abuelfadl AA, Sarhan NI. Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists. J Appl Toxicol. 2013;33(3):196-201.

Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

Yıl 2019, Cilt: 9 Sayı: 2, 166 - 170, 30.06.2019

Cagatay Oltulu Tugce Yesil Devecioglu Melek Akinci Sevcan Gul Akgun Olmez Serra Vildan Obeidin Ayfer Beceren

https://doi.org/10.33808/clinexphealthsci.563988

Cited By: 3

Öz

Objective: DNA damage that can be caused by workplace exposure to antineoplastic drugs in health workers has been shown in many scientific studies. It is aimed to evaluate whether the risk of genotoxicity in health workers decreases after the regulations and measures taken by national and international health authorities in our work.

Methods: For this purpose, DNA damage was assessed by using alkaline comet technique in lymphocytes isolated from blood samples of health workers (n=29) who were involved in preparing and / or administering antineoplastic agent at Trakya University Health Research and Application Center and compared with the control group (n=30). Also, those who prepare and/or administer antineoplastic agents; (n=16) and manual (n=13) preparations.

Results: As a result of the evaluation, there was no statistically significant difference between health personnel and control group in preparing and / or administering antineoplastic agent (p>0,05, Mann-Whitney U) and there was no difference in the genotoxic risk between preparation forms. Furthermore, when the exposed control group was assessed for DNA damage as smokers and nonsmokers, there was no statistically significant difference in terms of DNA damage (p>0.05).

Conclusion: At the center where our samples were taken, the resulting measures resulted in the control of the risk of genotoxicity due to occupational exposure to antineoplastic agents.

Anahtar Kelimeler

Alkaline Comet Assay, Genotoxicity, Antineoplastic, Occupational exposure, Occupational health safety

Kaynakça

1. El-Ebiary AA, Abuelfadl AA, Sarhan NI. Evaluation of genotoxicity induced by exposure to antineoplastic drugs in lymphocytes of oncology nurses and pharmacists. J Appl Toxicol. 2013;33(3):196-201.

Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Sağlık Kurumları Yönetimi
Bölüm	Articles
Yazarlar	Cagatay Oltulu 0000-0002-6051-3479 Tugce Yesil Devecioglu Bu kişi benim 0000-0002-7157-3442 Melek Akinci Bu kişi benim 0000-0003-3879-4232 Sevcan Gul Akgun Olmez Bu kişi benim 0000-0003-1326-8295 Serra Vildan Obeidin Bu kişi benim 0000-0003-0138-2445 Ayfer Beceren Bu kişi benim 0000-0002-6770-6089
Yayımlanma Tarihi	30 Haziran 2019
Gönderilme Tarihi	27 Nisan 2018
Yayımlandığı Sayı	Yıl 2019 Cilt: 9 Sayı: 2

Kaynak Göster

APA	Oltulu, C., Yesil Devecioglu, T., Akinci, M., Akgun Olmez, S. G., vd. (2019). Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clinical and Experimental Health Sciences, 9(2), 166-170. https://doi.org/10.33808/clinexphealthsci.563988
AMA	Oltulu C, Yesil Devecioglu T, Akinci M, Akgun Olmez SG, Obeidin SV, Beceren A. Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clinical and Experimental Health Sciences. Haziran 2019;9(2):166-170. doi:10.33808/clinexphealthsci.563988
Chicago	Oltulu, Cagatay, Tugce Yesil Devecioglu, Melek Akinci, Sevcan Gul Akgun Olmez, Serra Vildan Obeidin, ve Ayfer Beceren. “Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs”. Clinical and Experimental Health Sciences 9, sy. 2 (Haziran 2019): 166-70. https://doi.org/10.33808/clinexphealthsci.563988.
EndNote	Oltulu C, Yesil Devecioglu T, Akinci M, Akgun Olmez SG, Obeidin SV, Beceren A (01 Haziran 2019) Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clinical and Experimental Health Sciences 9 2 166–170.
IEEE	C. Oltulu, T. Yesil Devecioglu, M. Akinci, S. G. Akgun Olmez, S. V. Obeidin, ve A. Beceren, “Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs”, Clinical and Experimental Health Sciences, c. 9, sy. 2, ss. 166–170, 2019, doi: 10.33808/clinexphealthsci.563988.
ISNAD	Oltulu, Cagatay vd. “Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs”. Clinical and Experimental Health Sciences 9/2 (Haziran 2019), 166-170. https://doi.org/10.33808/clinexphealthsci.563988.
JAMA	Oltulu C, Yesil Devecioglu T, Akinci M, Akgun Olmez SG, Obeidin SV, Beceren A. Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clinical and Experimental Health Sciences. 2019;9:166–170.
MLA	Oltulu, Cagatay vd. “Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs”. Clinical and Experimental Health Sciences, c. 9, sy. 2, 2019, ss. 166-70, doi:10.33808/clinexphealthsci.563988.
Vancouver	Oltulu C, Yesil Devecioglu T, Akinci M, Akgun Olmez SG, Obeidin SV, Beceren A. Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs. Clinical and Experimental Health Sciences. 2019;9(2):166-70.