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Year 2021, Volume: 2 Issue: 3, 136 - 145, 22.09.2021

Damla Çınar Sedanur Sarı Hüseyin Alkan Kübra Buket Ay Enes Borcaktepe Ahmet Yiğit Duyum Sude Sevcan Filikçi Eren Gençer Çağla Senem Serhat Soylu Şeyma Tuna Rabia Tuncer Mehmet Emin Yazıcı Emre Altıntaş Murat Gül

Abstract

References

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  • 2. Paulis G, Romano G, Paulis A. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie’s disease: a retrospective analysis of 309 cases. Res Rep Urol. 2016;8:95-103.
  • 3. Sasso F, Gulino G, Falabella R, D’Addessi A, Sacco E, D’Onofrio A et al. Peyronie’s disease: lights and shadows. Urol Int. 2007;78(1):1-9.
  • 4. Patel DP, Christensen MB, Hotaling JM, Pastuszak AW. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie’s disease. World J Urol. 2020;38(2):253-261.
  • 5. Armağan A, Soyupek S, Hoşcan B. Peyronie hastalığının medikal tedavisindeki yenilikler. Androloji Bülteni. 2004;6(17):93-98
  • 6. Hussein AA, Alwaal A, Lue TF. All about Peyronie’s disease. Asian J Urol. 2015;2(2):70-78.
  • 7. Hellstrom WJ, Bivalacqua TJ. Peyronie’s disease: etiology, medical, and surgical therapy. J Androl. 2000;21(3):347-54.
  • 8. Mynderse LA, Monga M. Oral therapy for Peyronie’s disease. Int J Impot Res. 2002;14(5):340-4.
  • 9. Akkus E, Yıldırım Ö. Peyronie hastalığı. In: Doğan HS, editor. Ürolojik Cerrahi Kitabı. İstanbul:Galenos; 2020. p. 289-319
  • 10. Prieto Castro RM, Leva Vallejo ME, Regueiro Lopez JC, Anglada Curado FJ, Alvarez Kindelan J, Requena Tapia MJ. Combined treatment with vitamin E and colchicine in the early stages of Peyronie’s disease. BJU Int. 2003;91(6):522-4.
  • 11. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J et al. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie’s fibrotic plaque and in its rat model. Nitric Oxide. 2002;7(4):262-76.
  • 12. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie’s fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003;9(4):229-44.
  • 13. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie’s disease. BJU Int. 2006;97(3):625-33.
  • 14. Ozturk U, Yesil S, Goktug HN, Gucuk A, Tuygun C, Sener NC et al. Effects of sildenafil treatment on patients with Peyronie’s disease and erectile dysfunction. Ir J Med Sci. 2014;183(3):449-53.
  • 15. Chung E, Deyoung L, Brock GB. The role of PDE5 inhibitors in penile septal scar remodeling: assessment of clinical and radiological outcomes. J Sex Med. 2011;8(5):1472-7.
  • 16. Palmieri A, Imbimbo C, Creta M, Verze P, Fusco F, Mirone V. Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie’s disease and erectile dysfunction: results from a prospective randomized trial. Int J Androl. 2012;35(2):190-5.
  • 17. Bremer J. Carnitine--metabolism and functions. Physiol Rev. 1983;63(4):1420-80.
  • 18. Yafi FA, Pinsky MR, Sangkum P, Hellstrom WJ. Therapeutic advances in the treatment of Peyronie’s disease. Andrology. 2015;3(4):650-60.
  • 19. Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in theoral therapy of Peyronie’s disease: a preliminary report. BJU Int. 2001;88(1):63-7.
  • 20. Cavallini G, Biagiotti G, Koverech A, Vitali G. Oral propionyl-lcarnitine and intraplaque Verapamil in the therapy of advanced and resistant Peyronie’s disease. BJU Int. 2002;89(9):895-900.
  • 21. Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized study. Int J Impot Res. 2010;22(5):298-309
  • 22. Amasyalı AS. Peyronie hastalığının medikal tedavisinde neler değişti: 2015 güncelleme. Androloji bülteni.2015;17(62): 169-173169-173.
  • 23. Russo GI, Cacciamani G, Cocci A, Kessler TM, Morgia G, Serefoglu EC, et al. Comparative Effectiveness of Intralesional Therapy for Peyronie’s Disease in Controlled Clinical Studies: A Systematic Review and Network Meta-Analysis. J Sex Med. 2019 Feb;16(2):289-299.
  • 24. Levine LA. Peyronie’s disease: A contemporary review of non-surgical treatment. Arab J Urol. 2013;11(3):278-83.
  • 25. Weidner W, Hauck EW, Schnitker J; Peyronie’s Disease Study Group of Andrological Group of German Urologists. Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie’s disease: a prospective, placebo-controlled, randomized study. Eur Urol. 2005;47(4):530-5; discussion 535-6
  • 26. Hellstrom WJ. Medical management of Peyronie’s disease. J Androl. 2009 Jul-Aug;30(4):397-405.
  • 27. Roy J, Carrier S. Acute hepatitis associated with treatment of Peyronie’s disease with potassium para-aminobenzoate (Potaba). J Sex Med. 2008;5(12):2967-9
  • 28. Shaw EJ, Mitchell GC, Tan RB, Sangkum P, Hellstrom WJ. The nonsurgical treatment of peyronie disease: 2013 update. World J Mens Health. 2013;31(3):183-92.
  • 29. Chung E, Ralph D, Kagioglu A, Garaffa G, Shamsodini A, Bivalacqua T, Glina S, Hakim L, Sadeghi-Nejad H, Broderick G. Evidence- Based Management Guidelines on Peyronie’s Disease. J Sex Med. 2016;13(6):905-23
  • 30. El-Sakka AI, Salabas E, Dinçer M, Kadioglu A. The pathophysiology of Peyronie’s disease. Arab J Urol. 2013;11(3):272-7.
  • 31. Randhawa K, Shukla CJ. Non-invasive treatment in the management of Peyronie’s disease. Ther Adv Urol. 2019;11:1756287218823671.
  • 32. Asali M, Asali M. Intralesional injection of the calcium channel blocker Verapamil in Peyronie’s disease: A critical review. Arch Ital Urol Androl. 2020;92(3).
  • 33. Martin DJ, Badwan K, Parker M, Mulhall JP. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunicaalbuginea. J Urol. 2002;168(6):2483-5.
  • 34. Kokab A, Wylie K, Allen P, Shetty A, Davies-South D. Structured Self- Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease. Adv Urol. 2014;957013.
  • 35. Hatzimouratidis, K., F. Giuliano, I. Moncada, A. Muneer and A. Salonia. EAU guidelines on erectile dysfunction , premature ejaculation, penile curvature and priapism. 2017. Available at https://uroweb. org/wp-content/uploads/16-Malpdf. Accessed May 20, 2021
  • 36. Zemtsov A, Gaddis M, Montalvo-Lugo VM. Moisturizing and cosmetic properties of emu oil: a pilot double blind study. Australas J Dermatol. 1996;37(3):159-61.
  • 37. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003;167(12):1600-19.
  • 38. Kouoh F, Gressier B, Dine T, Luyckx M, Brunet C, Ballester L, Cazin JC. Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists? Cardiovasc Drugs Ther. 2002;16(6):515-20.
  • 39. Twidwell J, Levine L. Topical treatment for acute phase Peyronie’s disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. Int J Impot Res. 2016;28(2):41-5.
  • 40. Riedl CR, Sternig P, Gallé G, Langmann F, Vcelar B, Vorauer K et al. Liposomal recombinant human superoxide dismutase for the treatment of Peyronie’s disease: a randomized placebo-controlled double-blind prospective clinical study. Eur Urol. 2005;48(4):656-61.
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Non-Surgical Treatment Options for Peyronie’s Disease

Year 2021, Volume: 2 Issue: 3, 136 - 145, 22.09.2021

Damla Çınar Sedanur Sarı Hüseyin Alkan Kübra Buket Ay Enes Borcaktepe Ahmet Yiğit Duyum Sude Sevcan Filikçi Eren Gençer Çağla Senem Serhat Soylu Şeyma Tuna Rabia Tuncer Mehmet Emin Yazıcı Emre Altıntaş Murat Gül

Abstract

Peyronie’s disease, which occurs with the formation of a fibrous plaque in the tunica albuginea; is a disease that causes some physical problems such as bending and shortening of the penis. There are surgical treatment methods of this disease as well as non-surgical treatment methods. Non-surgical treatment methods, which are grouped under six headings: oral treatments, topical treatments, traction and vacuum treatments, shock wave therapy, intraplate injection treatments, and experimental treatments, can be preferred in cases where the symptoms are not very advanced because they provide advantages in terms of ease of application, accessibility, and cost. Although the only non-surgical treatment method approved by the FDA (U.S. Food and Drug Administration) yet is clostridium collagenase histolikum, which is used in intraplaque injection, studies have shown that other methods also reduce curvature, pain, and plaque volume.

Keywords

Peyronie’s Disease Non-Surgical Treatment Plaque.

References

  • 1. Ory J, MacDonald L, Langille G. Noninvasive Treatment Options for Peyronie’s Disease. Sex Med Rev. 2020;8(4):603-614.
  • 2. Paulis G, Romano G, Paulis A. Prevalence, psychological impact, and risk factors of erectile dysfunction in patients with Peyronie’s disease: a retrospective analysis of 309 cases. Res Rep Urol. 2016;8:95-103.
  • 3. Sasso F, Gulino G, Falabella R, D’Addessi A, Sacco E, D’Onofrio A et al. Peyronie’s disease: lights and shadows. Urol Int. 2007;78(1):1-9.
  • 4. Patel DP, Christensen MB, Hotaling JM, Pastuszak AW. A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie’s disease. World J Urol. 2020;38(2):253-261.
  • 5. Armağan A, Soyupek S, Hoşcan B. Peyronie hastalığının medikal tedavisindeki yenilikler. Androloji Bülteni. 2004;6(17):93-98
  • 6. Hussein AA, Alwaal A, Lue TF. All about Peyronie’s disease. Asian J Urol. 2015;2(2):70-78.
  • 7. Hellstrom WJ, Bivalacqua TJ. Peyronie’s disease: etiology, medical, and surgical therapy. J Androl. 2000;21(3):347-54.
  • 8. Mynderse LA, Monga M. Oral therapy for Peyronie’s disease. Int J Impot Res. 2002;14(5):340-4.
  • 9. Akkus E, Yıldırım Ö. Peyronie hastalığı. In: Doğan HS, editor. Ürolojik Cerrahi Kitabı. İstanbul:Galenos; 2020. p. 289-319
  • 10. Prieto Castro RM, Leva Vallejo ME, Regueiro Lopez JC, Anglada Curado FJ, Alvarez Kindelan J, Requena Tapia MJ. Combined treatment with vitamin E and colchicine in the early stages of Peyronie’s disease. BJU Int. 2003;91(6):522-4.
  • 11. Vernet D, Ferrini MG, Valente EG, Magee TR, Bou-Gharios G, Rajfer J et al. Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie’s fibrotic plaque and in its rat model. Nitric Oxide. 2002;7(4):262-76.
  • 12. Valente EG, Vernet D, Ferrini MG, Qian A, Rajfer J, Gonzalez-Cadavid NF. L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie’s fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003;9(4):229-44.
  • 13. Ferrini MG, Kovanecz I, Nolazco G, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie’s disease. BJU Int. 2006;97(3):625-33.
  • 14. Ozturk U, Yesil S, Goktug HN, Gucuk A, Tuygun C, Sener NC et al. Effects of sildenafil treatment on patients with Peyronie’s disease and erectile dysfunction. Ir J Med Sci. 2014;183(3):449-53.
  • 15. Chung E, Deyoung L, Brock GB. The role of PDE5 inhibitors in penile septal scar remodeling: assessment of clinical and radiological outcomes. J Sex Med. 2011;8(5):1472-7.
  • 16. Palmieri A, Imbimbo C, Creta M, Verze P, Fusco F, Mirone V. Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie’s disease and erectile dysfunction: results from a prospective randomized trial. Int J Androl. 2012;35(2):190-5.
  • 17. Bremer J. Carnitine--metabolism and functions. Physiol Rev. 1983;63(4):1420-80.
  • 18. Yafi FA, Pinsky MR, Sangkum P, Hellstrom WJ. Therapeutic advances in the treatment of Peyronie’s disease. Andrology. 2015;3(4):650-60.
  • 19. Biagiotti G, Cavallini G. Acetyl-L-carnitine vs tamoxifen in theoral therapy of Peyronie’s disease: a preliminary report. BJU Int. 2001;88(1):63-7.
  • 20. Cavallini G, Biagiotti G, Koverech A, Vitali G. Oral propionyl-lcarnitine and intraplaque Verapamil in the therapy of advanced and resistant Peyronie’s disease. BJU Int. 2002;89(9):895-900.
  • 21. Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized study. Int J Impot Res. 2010;22(5):298-309
  • 22. Amasyalı AS. Peyronie hastalığının medikal tedavisinde neler değişti: 2015 güncelleme. Androloji bülteni.2015;17(62): 169-173169-173.
  • 23. Russo GI, Cacciamani G, Cocci A, Kessler TM, Morgia G, Serefoglu EC, et al. Comparative Effectiveness of Intralesional Therapy for Peyronie’s Disease in Controlled Clinical Studies: A Systematic Review and Network Meta-Analysis. J Sex Med. 2019 Feb;16(2):289-299.
  • 24. Levine LA. Peyronie’s disease: A contemporary review of non-surgical treatment. Arab J Urol. 2013;11(3):278-83.
  • 25. Weidner W, Hauck EW, Schnitker J; Peyronie’s Disease Study Group of Andrological Group of German Urologists. Potassium paraaminobenzoate (POTABA) in the treatment of Peyronie’s disease: a prospective, placebo-controlled, randomized study. Eur Urol. 2005;47(4):530-5; discussion 535-6
  • 26. Hellstrom WJ. Medical management of Peyronie’s disease. J Androl. 2009 Jul-Aug;30(4):397-405.
  • 27. Roy J, Carrier S. Acute hepatitis associated with treatment of Peyronie’s disease with potassium para-aminobenzoate (Potaba). J Sex Med. 2008;5(12):2967-9
  • 28. Shaw EJ, Mitchell GC, Tan RB, Sangkum P, Hellstrom WJ. The nonsurgical treatment of peyronie disease: 2013 update. World J Mens Health. 2013;31(3):183-92.
  • 29. Chung E, Ralph D, Kagioglu A, Garaffa G, Shamsodini A, Bivalacqua T, Glina S, Hakim L, Sadeghi-Nejad H, Broderick G. Evidence- Based Management Guidelines on Peyronie’s Disease. J Sex Med. 2016;13(6):905-23
  • 30. El-Sakka AI, Salabas E, Dinçer M, Kadioglu A. The pathophysiology of Peyronie’s disease. Arab J Urol. 2013;11(3):272-7.
  • 31. Randhawa K, Shukla CJ. Non-invasive treatment in the management of Peyronie’s disease. Ther Adv Urol. 2019;11:1756287218823671.
  • 32. Asali M, Asali M. Intralesional injection of the calcium channel blocker Verapamil in Peyronie’s disease: A critical review. Arch Ital Urol Androl. 2020;92(3).
  • 33. Martin DJ, Badwan K, Parker M, Mulhall JP. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunicaalbuginea. J Urol. 2002;168(6):2483-5.
  • 34. Kokab A, Wylie K, Allen P, Shetty A, Davies-South D. Structured Self- Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease. Adv Urol. 2014;957013.
  • 35. Hatzimouratidis, K., F. Giuliano, I. Moncada, A. Muneer and A. Salonia. EAU guidelines on erectile dysfunction , premature ejaculation, penile curvature and priapism. 2017. Available at https://uroweb. org/wp-content/uploads/16-Malpdf. Accessed May 20, 2021
  • 36. Zemtsov A, Gaddis M, Montalvo-Lugo VM. Moisturizing and cosmetic properties of emu oil: a pilot double blind study. Australas J Dermatol. 1996;37(3):159-61.
  • 37. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003;167(12):1600-19.
  • 38. Kouoh F, Gressier B, Dine T, Luyckx M, Brunet C, Ballester L, Cazin JC. Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists? Cardiovasc Drugs Ther. 2002;16(6):515-20.
  • 39. Twidwell J, Levine L. Topical treatment for acute phase Peyronie’s disease utilizing a new gel, H-100: a randomized, prospective, placebo-controlled pilot study. Int J Impot Res. 2016;28(2):41-5.
  • 40. Riedl CR, Sternig P, Gallé G, Langmann F, Vcelar B, Vorauer K et al. Liposomal recombinant human superoxide dismutase for the treatment of Peyronie’s disease: a randomized placebo-controlled double-blind prospective clinical study. Eur Urol. 2005;48(4):656-61.
  • 41. Canadian Agency for Drugs and Technologies in Health Rapid Response Reports. The use of the electromotive drug administration system in patients with overactive bladder: A review of the clinical effectiveness, safety, and cost-effectiveness. Ottawa (ON). 2014. Available at https://www.ncbi.nlm.nih.gov/books/NBK253337/. Accessed May 22, 2021
  • 42. Mehrsai AR, Namdari F, Salavati A, Dehghani S, Allameh F, Pourmand G. Comparison of transdermal electromotive administration of Verapamil and dexamethasone versus intra-lesional injection for Peyronie’s disease. Andrology. 2013;1(1):129-32.
  • 43. Valenzuela R, Ziegelmann M, Tokar S, Hillelsohn J. The use of penile traction therapy in the management of Peyronie’s disease: current evidence and future prospects. Ther Adv Urol. 2019;11:1756287219838139.
  • 44. Scroppo FI, Mancini M, Maggi M, Colpi GM. Can an external penis stretcher reduce Peyronie’s penile curvature? Int J Impot Res. 2001;13(4)
  • 45. Levine LA, Newell M, Taylor FL. Penile traction therapy for treatment of Peyronie’s disease: a single-center pilot study. J Sex Med. 2008;5(6):1468-73.
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There are 69 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section REVIEW ARTICLE
Authors

Damla Çınar This is me 0000-0003-4720-9592

Sedanur Sarı This is me 0000-0003-4720-9592

Hüseyin Alkan This is me 0000-0001-9927-8595

Kübra Buket Ay This is me 0000-0002-3876-2700

Enes Borcaktepe This is me 0000-0003-4756-7795

Ahmet Yiğit Duyum 0000-0002-0232-0089

Sude Sevcan Filikçi This is me 0000-0002-2123-2498

Eren Gençer This is me 0000-0002-6808-4795

Çağla Senem This is me 0000-0001-6239-8323

Serhat Soylu This is me 0000-0001-9392-8825

Şeyma Tuna This is me 0000-0002-6848-6612

Rabia Tuncer This is me 0000-0002-5417-9574

Mehmet Emin Yazıcı This is me 0000-0001-7825-931X

Emre Altıntaş This is me 0000-0002-6797-3937

Murat Gül 0000-0002-6657-6227

Publication Date September 22, 2021
Submission Date June 13, 2021
Published in Issue Year 2021 Volume: 2 Issue: 3

Cite

APA Çınar, D., Sarı, S., Alkan, H., Ay, K. B., et al. (2021). Non-Surgical Treatment Options for Peyronie’s Disease. Archives of Current Medical Research, 2(3), 136-145.
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