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Resveratrol in rheumatologic diseases: A narrative review

Year 2024, Volume: 29 Issue: 1, 94 - 99, 27.01.2024
https://doi.org/10.21673/anadoluklin.1376477

Abstract

Resveratrol (3,5,4′-trihydroxystilbene) was first isolated from Veratrum grandiflorum by Takaoka in 1939; it is a natural polyphenol contained in plants such as grapes, strawberries, and blueberries. Many studies show that resveratrol modulates apoptosis and improves mitochondrial function by suppressing oxidative stress and inhibiting the inflammatory response. Rheumatological diseases are a heterogeneous group that includes autoimmune disease groups including systemic vasculitis such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), Takayasu arteritis (TA), and inflammatory arthritis such as spondyloarthritis, gouty arthritis, and osteoarthritis. The main goal of the treatment of rheumatological diseases is the suppression of inflammation. The aim of this review is to summarize recent experimental and randomized controlled clinical studies on the use and effects of resveratrol in rheumatological diseases. Resveratrol has been shown to be effective against many rheumatological diseases in experimental animal models. Although there are few studies on resveratrol in the rheumatological patient group, its use has been recommended as a supplement to traditional treatments. More studies are needed to evaluate the effectiveness, drug interactions, and side effects of resveratrol in rheumatological diseases.

Ethical Statement

Derleme olduğu için etik kurul onayı alınmamıştır.

Supporting Institution

Yoktur.

Thanks

Yoktur.

References

  • Takaoka M. Takaoka M. Resveratrol, a new phenolic compound, from Veratrum grandiflorum. J Chem Soc Jpn. 1939;60:1090–100.
  • Ginés C, Cuesta S, Kireev R, et al. Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice. Exp Gerontol. 2017;90:61-70.
  • Calabrese EJ, Mattson MP, Calabrese V. Resveratrol commonly displays hormesis: occurrence and biomedical significance. Hum Exp Toxicol. 2010;29(12):980–1015.
  • Posadino AM, Cossu A, Giordo R, et al. Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death. Food Chem Toxicol. 2015;1;78:10–6.
  • Oz B, Yildirim A, Yolbas S, et al. Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model. Biofactors. 2019;45(1):69–74.
  • Genovese T, Impellizzeri D, D’Amico R, et al. Resveratrol Inhibition of the WNT/β-Catenin Pathway following Discogenic Low Back Pain. Int J Mol Sci. 2022;23(8):4092.
  • Hussain SA, Marouf BH, Ali ZS, Ahmmad RS. Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study. Clin Interv Aging. 2018;13:1621-30.
  • Yao Q, Wu Q, Xu X, et al. Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling. Drug Des Devel Ther. 2020;14:5337-48.
  • Molnar V, Matišić V, Kodvanj I, et al. Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis. Int J Mol Sci. 2021;22(17):9208.
  • Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21(1):16-21.
  • Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167-75.
  • Yang S, Sun M, Zhang X. Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials. Front Pharmacol. 2022;13:921003.
  • Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int. 2021;41(5):863-77.
  • Riveiro-Naveira RR, Valcárcel-Ares MN, Almonte-Becerril M, et al. Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model. Rheumatology (Oxford). 2016;55(10):1889-900.
  • Lomholt S, Mellemkjaer A, Iversen MB, Pedersen SB, Kragstrup TW. Resveratrol displays anti-inflammatory properties in an ex vivo model of immune mediated inflammatory arthritis. BMC Rheumatol. 2018;2:27.
  • Khojah HM, Ahmed S, Abdel-Rahman MS, Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol. 2018;37(8):2035-42.
  • Chen H, Zheng S, Wang Y, et al. The effect of resveratrol on the recurrent attacks of gouty arthritis. Clin Rheumatol. 2016;35(5):1189-95.
  • Fan W, Chen S, Wu X, Zhu J, Li J. Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes. J Inflamm Res. 2021;14:3523-36.
  • Yang QB, He YL, Zhong XW, Xie WG, Zhou JG. Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. Inflammopharmacology. 2019;27(1):47-56.
  • Ding MH, Xu PG, Wang Y, Ren BD, Zhang JL. Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota. Immunol Invest. 2023;52(2):194-209.
  • Kjær TN, Thorsen K, Jessen N, Stenderup K, Pedersen SB. Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS One. 2015;10(5):e0126599.
  • Mackensen A, Müller F, Mougiakakos D, et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2022;28(10):2124-32.
  • Wang ZL, Luo XF, Li MT, et al. Resveratrol possesses protective effects in a pristane-induced lupus mouse model. PLoS One. 2014;9(12):e114792.
  • Voloshyna I, Teboul I, Littlefield MJ, et al. Resveratrol counters systemic lupus erythematosus-associated atherogenicity by normalizing cholesterol efflux. Exp Biol Med (Maywood). 2016;241(14):1611-9.
  • Sanchez-Alvarez C, Crowson CS, Koster MJ, Warrington KJ. Prevalence of Takayasu Arteritis: A Population-based Study. J Rheumatol. 2021;48(6):952.
  • Shi G, Hua M, Xu Q, Ren T. Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial. Immunobiology. 2017;222(2):164-8.

Romatolojik hastalıklarda resveratrol: Geleneksel derleme

Year 2024, Volume: 29 Issue: 1, 94 - 99, 27.01.2024
https://doi.org/10.21673/anadoluklin.1376477

Abstract

Resveratrol (RE; (3,5,4′-trihydroxystilbene)) ilk olarak 1939’da Takaoka tarafından Veratrum grandiflorum’dan izole edilen; üzüm, çilek ve yaban mersini gibi bitkilerde bulunan doğal bir polifenoldür. Birçok çalışma resveratrolün oksidatif stresi baskılayıp, inflamatuar yanıtı azaltarak, mitokondriyal fonksiyonları iyileştirdiğini ve apoptozu modüle ettiğini göstermiştir. Romatolojik hastalıklar sistemik lupus eritematozus (SLE), sistemik skleroz (SSc), romatoid artrit (RA), Takayasu arteriti (TA) gibi sistemik vaskülitleri de içeren otoimmun hastalıklar grubu ile spondiloartritler, gut, osteoartrit gibi inflamatuvar artritleri de içeren heterojen bir hastalık grubudur. Romatolojik hastalıkların tedavisinde ana hedef inflamasyonun baskılanmasıdır. Bu derlemenin amacı, resveratrolün romatolojik hastalıklarda kullanımı ve etkilerine dair yayınlanmış güncel, deneysel ve randomize kontrollü klinik çalışmaları derleyerek son bilgileri özetlemektir. Resveratrolün deney hayvan modellerinde birçok romatolojik hastalığa karşı etkili olduğu gösterilmiştir. Resveratrolün, romatolojik hasta grubunda az sayıda çalışması olmakla birlikte geleneksel tedavilere destek olarak kullanımı önerilmiştir. Resveratrolün romatolojik hastalıklardaki etkinliğini, ilaç etkileşimlerini ve yan etkilerini değerlendirmek için daha fazla çalışmaya ihtiyaç vardır.

References

  • Takaoka M. Takaoka M. Resveratrol, a new phenolic compound, from Veratrum grandiflorum. J Chem Soc Jpn. 1939;60:1090–100.
  • Ginés C, Cuesta S, Kireev R, et al. Protective effect of resveratrol against inflammation, oxidative stress and apoptosis in pancreas of aged SAMP8 mice. Exp Gerontol. 2017;90:61-70.
  • Calabrese EJ, Mattson MP, Calabrese V. Resveratrol commonly displays hormesis: occurrence and biomedical significance. Hum Exp Toxicol. 2010;29(12):980–1015.
  • Posadino AM, Cossu A, Giordo R, et al. Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death. Food Chem Toxicol. 2015;1;78:10–6.
  • Oz B, Yildirim A, Yolbas S, et al. Resveratrol inhibits Src tyrosine kinase, STAT3, and Wnt signaling pathway in collagen induced arthritis model. Biofactors. 2019;45(1):69–74.
  • Genovese T, Impellizzeri D, D’Amico R, et al. Resveratrol Inhibition of the WNT/β-Catenin Pathway following Discogenic Low Back Pain. Int J Mol Sci. 2022;23(8):4092.
  • Hussain SA, Marouf BH, Ali ZS, Ahmmad RS. Efficacy and safety of co-administration of resveratrol with meloxicam in patients with knee osteoarthritis: a pilot interventional study. Clin Interv Aging. 2018;13:1621-30.
  • Yao Q, Wu Q, Xu X, et al. Resveratrol Ameliorates Systemic Sclerosis via Suppression of Fibrosis and Inflammation Through Activation of SIRT1/mTOR Signaling. Drug Des Devel Ther. 2020;14:5337-48.
  • Molnar V, Matišić V, Kodvanj I, et al. Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis. Int J Mol Sci. 2021;22(17):9208.
  • Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21(1):16-21.
  • Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med. 2018;52(3):167-75.
  • Yang S, Sun M, Zhang X. Protective Effect of Resveratrol on Knee Osteoarthritis and its Molecular Mechanisms: A Recent Review in Preclinical and Clinical Trials. Front Pharmacol. 2022;13:921003.
  • Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int. 2021;41(5):863-77.
  • Riveiro-Naveira RR, Valcárcel-Ares MN, Almonte-Becerril M, et al. Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model. Rheumatology (Oxford). 2016;55(10):1889-900.
  • Lomholt S, Mellemkjaer A, Iversen MB, Pedersen SB, Kragstrup TW. Resveratrol displays anti-inflammatory properties in an ex vivo model of immune mediated inflammatory arthritis. BMC Rheumatol. 2018;2:27.
  • Khojah HM, Ahmed S, Abdel-Rahman MS, Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol. 2018;37(8):2035-42.
  • Chen H, Zheng S, Wang Y, et al. The effect of resveratrol on the recurrent attacks of gouty arthritis. Clin Rheumatol. 2016;35(5):1189-95.
  • Fan W, Chen S, Wu X, Zhu J, Li J. Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes. J Inflamm Res. 2021;14:3523-36.
  • Yang QB, He YL, Zhong XW, Xie WG, Zhou JG. Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients. Inflammopharmacology. 2019;27(1):47-56.
  • Ding MH, Xu PG, Wang Y, Ren BD, Zhang JL. Resveratrol Attenuates Ankylosing Spondylitis in Mice by Inhibiting the TLR4/NF-κB/NLRP3 Pathway and Regulating Gut Microbiota. Immunol Invest. 2023;52(2):194-209.
  • Kjær TN, Thorsen K, Jessen N, Stenderup K, Pedersen SB. Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS One. 2015;10(5):e0126599.
  • Mackensen A, Müller F, Mougiakakos D, et al. Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus. Nat Med. 2022;28(10):2124-32.
  • Wang ZL, Luo XF, Li MT, et al. Resveratrol possesses protective effects in a pristane-induced lupus mouse model. PLoS One. 2014;9(12):e114792.
  • Voloshyna I, Teboul I, Littlefield MJ, et al. Resveratrol counters systemic lupus erythematosus-associated atherogenicity by normalizing cholesterol efflux. Exp Biol Med (Maywood). 2016;241(14):1611-9.
  • Sanchez-Alvarez C, Crowson CS, Koster MJ, Warrington KJ. Prevalence of Takayasu Arteritis: A Population-based Study. J Rheumatol. 2021;48(6):952.
  • Shi G, Hua M, Xu Q, Ren T. Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial. Immunobiology. 2017;222(2):164-8.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Pharmacology and Pharmaceutical Sciences (Other), Rheumatology and Arthritis
Journal Section REVİEW
Authors

Tuba Demirci Yıldırım 0000-0003-3186-0591

Publication Date January 27, 2024
Submission Date October 16, 2023
Acceptance Date November 23, 2023
Published in Issue Year 2024 Volume: 29 Issue: 1

Cite

Vancouver Demirci Yıldırım T. Romatolojik hastalıklarda resveratrol: Geleneksel derleme. Anatolian Clin. 2024;29(1):94-9.

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.