Review
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Year 2024, Volume: 30 Issue: 2, 205 - 215, 26.03.2024
https://doi.org/10.15832/ankutbd.1349777

Abstract

References

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  • Alphonse P A S & Aluko R E (2015). Anti-carcinogenic and anti-metastatic effects of flax seed lignan secolariciresinol diglucoside (SDG). Discovery Phytomedicine 2: 12-17
  • Bak M J, Gupta S D, Wahler J & Suh N (2016). Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Seminars in Cancer Biology 40-41: 170-191
  • Basu P & Maier C (2018). Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. Biomedicine&Pharmacoyherapy 107: 1648-1666
  • Bernacchia R, Preti R & Vinci G (2014). Chemical Composition and Health Benefits of Flaxseed. Austin Journal of Nutrition and Food Sciences 2 (8):1045
  • Bhimjiyani V H, Borugadda V B, Naik S & Dalai A K (2021). Enrichment of flaxseed ( Linum usitatissimum) oil with carotenoids of sea buckthorn pomace via ultrasound-assisted extraction technique: Enrichment of flaxseed oil with sea buckthorn. Current Research in Food Science 4: 478-488
  • Bigdeli B, Goliaei B, Masoudi-Khoram N, Jooyan N, Nikoofar A, Rouhani M, Haghparast A & Mamashli F (2016). Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicology and Applied Pharmacology 313: 18-194
  • Bowers L W, Lineberger C G, Ford N A, Rossi E L, Punjala A, Camp K K, Kimler B K, Fabian C J & Hursting S D (2019). The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Research and Treatment 173(3): 545-557
  • Božović A, Mandušić V, Todorović L & Krajnović M (2021) Estrogen receptor beta: the promising biomarker and potential target in metastases. International Journal of Molecular Sciencies 22(4):1656
  • Britt K L, Cuzick J & Philips K A (2020). Key steps for effective breast cancer prevention. Nature Reviews Cancer 20 (8): 417-436.
  • Brooks J D & Thompson L U (2005). Mammalian lignans and genistein decrease the activities of aromatase and 17β-hydroxysteroid dehydrogenase in MCF-7 cells. The Journal of Steroid Biochemistry & Molecular Biology 94(5):461-467
  • Buckner A L, Buckner C A, Montaut S & Lafrenie R M (2019). Treatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon 9, 5(8): e02251
  • Calado A, Neves P M, Santos T & Ravasco P (2018). The Effect of Flaxseed in Breast Cancer: A Literature Review. Frontiers in Nutrition 5: 4
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  • Chang V C, Cotterchio M, Boucher B A, Jenkins D J A, Mirea L, McCann S E & Thompson L U (2019) Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutrition and Cancer 71(3): 385-398
  • Chen J, Stavro P M & Thompson L U (2002). Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. Nutrition and Cancer 43(2):187-192
  • Chen J, Hui E, Ip T & Thompson L U (2004). Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (mcf-7) in nude mice. Clinical cancer research 10(22): 7703-7711
  • Chen J, Wang L, Thompson L U (2006). Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. Cancer Letters 234(2): 168-175
  • Chen J, Saggar J K, Corey P & Thompson L U (2009). Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice. The Journal of Nutrition 139(11): 2061-2066
  • Chhillar H, Chopra P & Ashfaq M A (2021). Lignans from linseed (Linum usitatissimum L.) and its allied species: Retrospect, introspect and prospect. Critical Reviews in Food Science and Nutrition 61(16): 2719-2741
  • Daniel A R, Hagan C R & Lange C A (2011). Progesterone receptor action: defining a role in breast cancer. Expert Review of Endocrinology &Metabolism 6(3): 359-369
  • da Luz F A C, Araújo B J & de Araújo R A (2022). The current staging and classification systems of breast cancer and their pitfalls: is it possible to integrate the complexity of this neoplasm into a unified staging system? Critical Reviews in Oncology/Hematology 178: 103781
  • Das S, Kulkarni S, Singh Y, Kumar P & Thareja S (2022). Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview. Journal of Molecular Structure 1270: 133853
  • Di Y, De Silva F, Krol E S & Alcorn J (2018). Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. Nutrition and Cancer 70(2): 306-315
  • Dobrowolska K & Regulska-Ilow B (2021). The legitimacy of using dietary supplement diglycoside secoisolariciresinol (SDG) from flaxseed in cancer. Roczniki Panstwowego Zakladu Higieny 72(1): 9-20
  • Duffy C, Perez K & Partridge A (2007). Implications of phytoestrogen intake for breast cancer. CA: A Cancer Journal for Clinicians 57 (5): 260-277
  • Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, Ji X, Liu W, Huang B, Luo W, Liu B, Lei Y, Du S, Vuppalapati A, Luu H H, Haydon R C, He T C & Ren G (2018). Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes&Diseases 5(2): 77-106
  • Fuentes N & Silveyra P (2019). Estrogen receptor signaling mechanisms. Advances in Protein Chemistry and Structural Biology 116: 135-170
  • Global Cancer Observatory. http://gco.iarc.fr [accessed November 07, 2023]
  • Gorzkiewicz J, Bartosz G & Sadowska-Bartosz I (2021). The Potential Effects of Phytoestrogens: The Role in Neuroprotection. Molecules 26(10): 2954
  • Goyal A, Sharma V, Sihag M K, Tomar S K, Arora S, Sabikhi L & Singh A K (2015). Development and physico-chemical characterization of microencapsulated flaxseed oil powder: A functional ingredient for omega-3 fortification. Powder Technology 286: 527-537
  • Goyal A, Sharma V, Upadhyay N, Gill S & Sihag M (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology 51(9): 1633-1653
  • Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G & Costantini S (2017). Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. International Journal of Oncology 50(2): 468-476
  • He Q, Hu H, Yang F, Song D, Zhang X & Dai X (2023). Advances in chimeric antigen receptor T cells therapy in the treatment of breast cancer. Biomedicine&Pharmacotherapy 162: 114609
  • Helferich W G, Andrade J E & Hoagland M S (2008). Phytoestrogens and breast cancer: a complex story. Inflammopharmacology 16(5): 219-226
  • Hilton H N, Clarke C L, Graham J D (2018). Estrogen and progesterone signalling in the normal breast and its implications for cancer development. Molecular and Cellular Endocrinology 466: 2-14
  • Hu T, Linghu K, Huang S, Battino M, Georgiev M, Zengin G, Li D, Deng Y, Wang Y T & Cao H (2019). Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells. Food and chemical toxicology 127:188-196
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A Mini Review on Components of Flax Seed and Their Effects on Breast Cancer

Year 2024, Volume: 30 Issue: 2, 205 - 215, 26.03.2024
https://doi.org/10.15832/ankutbd.1349777

Abstract

Breast cancer is recognized as one of the most common cancers worldwide that can lead to death. Alternative treatment options are needed due to drug resistance caused by current treatment methods such as chemotherapy, inclusion of healthy cells in the target, and possible side effects. In this context, there is great interest in natural compounds and their active metabolites. One of these is flaxseed (FS), which is one of the most studied foods to be associated with breast cancer. FS is a functional food with high nutritional value. FS components (fatty acids, fiber, and lignans) and especially the basic lignan structure in FS content, secoisolariciresinol diglucoside (SDG) and its metabolites enterolactone (ENL) and enterodiol (END) have beneficial effects on breast cancer progression. This review aimed to develop a perspective for further research on this type of cancer in the future by giving some general information about FS and its components and evaluating some studies showing potential effects on breast cancer.

References

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  • Alphonse P A S & Aluko R E (2015). Anti-carcinogenic and anti-metastatic effects of flax seed lignan secolariciresinol diglucoside (SDG). Discovery Phytomedicine 2: 12-17
  • Bak M J, Gupta S D, Wahler J & Suh N (2016). Role of dietary bioactive natural products in estrogen receptor-positive breast cancer. Seminars in Cancer Biology 40-41: 170-191
  • Basu P & Maier C (2018). Phytoestrogens and breast cancer: In vitro anticancer activities of isoflavones, lignans, coumestans, stilbenes and their analogs and derivatives. Biomedicine&Pharmacoyherapy 107: 1648-1666
  • Bernacchia R, Preti R & Vinci G (2014). Chemical Composition and Health Benefits of Flaxseed. Austin Journal of Nutrition and Food Sciences 2 (8):1045
  • Bhimjiyani V H, Borugadda V B, Naik S & Dalai A K (2021). Enrichment of flaxseed ( Linum usitatissimum) oil with carotenoids of sea buckthorn pomace via ultrasound-assisted extraction technique: Enrichment of flaxseed oil with sea buckthorn. Current Research in Food Science 4: 478-488
  • Bigdeli B, Goliaei B, Masoudi-Khoram N, Jooyan N, Nikoofar A, Rouhani M, Haghparast A & Mamashli F (2016). Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicology and Applied Pharmacology 313: 18-194
  • Bowers L W, Lineberger C G, Ford N A, Rossi E L, Punjala A, Camp K K, Kimler B K, Fabian C J & Hursting S D (2019). The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth. Breast Cancer Research and Treatment 173(3): 545-557
  • Božović A, Mandušić V, Todorović L & Krajnović M (2021) Estrogen receptor beta: the promising biomarker and potential target in metastases. International Journal of Molecular Sciencies 22(4):1656
  • Britt K L, Cuzick J & Philips K A (2020). Key steps for effective breast cancer prevention. Nature Reviews Cancer 20 (8): 417-436.
  • Brooks J D & Thompson L U (2005). Mammalian lignans and genistein decrease the activities of aromatase and 17β-hydroxysteroid dehydrogenase in MCF-7 cells. The Journal of Steroid Biochemistry & Molecular Biology 94(5):461-467
  • Buckner A L, Buckner C A, Montaut S & Lafrenie R M (2019). Treatment with flaxseed oil induces apoptosis in cultured malignant cells. Heliyon 9, 5(8): e02251
  • Calado A, Neves P M, Santos T & Ravasco P (2018). The Effect of Flaxseed in Breast Cancer: A Literature Review. Frontiers in Nutrition 5: 4
  • Cancer Today, Global Cancer Observatory. https://gco.iarc.fr/today/data/factsheets/populations/792-turkey-fact–sheets.pdf [accessed November 07, 2023]
  • Ceccarelli I, Bioletti L, Peparini S, Solomita E, Ricci C, Casini I, Miceli E & Aloisi A M (2022). Estrogens and phytoestrogens in body functions. Nuroscience and Biobehavioral Reviews 132: 648-663
  • Chang V C, Cotterchio M, Boucher B A, Jenkins D J A, Mirea L, McCann S E & Thompson L U (2019) Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutrition and Cancer 71(3): 385-398
  • Chen J, Stavro P M & Thompson L U (2002). Dietary flaxseed inhibits human breast cancer growth and metastasis and downregulates expression of insulin-like growth factor and epidermal growth factor receptor. Nutrition and Cancer 43(2):187-192
  • Chen J, Hui E, Ip T & Thompson L U (2004). Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (mcf-7) in nude mice. Clinical cancer research 10(22): 7703-7711
  • Chen J, Wang L, Thompson L U (2006). Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice. Cancer Letters 234(2): 168-175
  • Chen J, Saggar J K, Corey P & Thompson L U (2009). Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice. The Journal of Nutrition 139(11): 2061-2066
  • Chhillar H, Chopra P & Ashfaq M A (2021). Lignans from linseed (Linum usitatissimum L.) and its allied species: Retrospect, introspect and prospect. Critical Reviews in Food Science and Nutrition 61(16): 2719-2741
  • Daniel A R, Hagan C R & Lange C A (2011). Progesterone receptor action: defining a role in breast cancer. Expert Review of Endocrinology &Metabolism 6(3): 359-369
  • da Luz F A C, Araújo B J & de Araújo R A (2022). The current staging and classification systems of breast cancer and their pitfalls: is it possible to integrate the complexity of this neoplasm into a unified staging system? Critical Reviews in Oncology/Hematology 178: 103781
  • Das S, Kulkarni S, Singh Y, Kumar P & Thareja S (2022). Selective Estrogen Receptor Modulators (SERMs) for the treatment of ER+ breast cancer: An overview. Journal of Molecular Structure 1270: 133853
  • Di Y, De Silva F, Krol E S & Alcorn J (2018). Flaxseed Lignans Enhance the Cytotoxicity of Chemotherapeutic Agents against Breast Cancer Cell Lines MDA-MB-231 and SKBR3. Nutrition and Cancer 70(2): 306-315
  • Dobrowolska K & Regulska-Ilow B (2021). The legitimacy of using dietary supplement diglycoside secoisolariciresinol (SDG) from flaxseed in cancer. Roczniki Panstwowego Zakladu Higieny 72(1): 9-20
  • Duffy C, Perez K & Partridge A (2007). Implications of phytoestrogen intake for breast cancer. CA: A Cancer Journal for Clinicians 57 (5): 260-277
  • Feng Y, Spezia M, Huang S, Yuan C, Zeng Z, Zhang L, Ji X, Liu W, Huang B, Luo W, Liu B, Lei Y, Du S, Vuppalapati A, Luu H H, Haydon R C, He T C & Ren G (2018). Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis. Genes&Diseases 5(2): 77-106
  • Fuentes N & Silveyra P (2019). Estrogen receptor signaling mechanisms. Advances in Protein Chemistry and Structural Biology 116: 135-170
  • Global Cancer Observatory. http://gco.iarc.fr [accessed November 07, 2023]
  • Gorzkiewicz J, Bartosz G & Sadowska-Bartosz I (2021). The Potential Effects of Phytoestrogens: The Role in Neuroprotection. Molecules 26(10): 2954
  • Goyal A, Sharma V, Sihag M K, Tomar S K, Arora S, Sabikhi L & Singh A K (2015). Development and physico-chemical characterization of microencapsulated flaxseed oil powder: A functional ingredient for omega-3 fortification. Powder Technology 286: 527-537
  • Goyal A, Sharma V, Upadhyay N, Gill S & Sihag M (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of Food Science and Technology 51(9): 1633-1653
  • Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G & Costantini S (2017). Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. International Journal of Oncology 50(2): 468-476
  • He Q, Hu H, Yang F, Song D, Zhang X & Dai X (2023). Advances in chimeric antigen receptor T cells therapy in the treatment of breast cancer. Biomedicine&Pharmacotherapy 162: 114609
  • Helferich W G, Andrade J E & Hoagland M S (2008). Phytoestrogens and breast cancer: a complex story. Inflammopharmacology 16(5): 219-226
  • Hilton H N, Clarke C L, Graham J D (2018). Estrogen and progesterone signalling in the normal breast and its implications for cancer development. Molecular and Cellular Endocrinology 466: 2-14
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There are 87 citations in total.

Details

Primary Language English
Subjects Agricultural Engineering (Other)
Journal Section Makaleler
Authors

İrem Bayar 0000-0002-9363-5085

Senem Akkoç 0000-0002-1260-9425

Publication Date March 26, 2024
Submission Date August 25, 2023
Acceptance Date November 16, 2023
Published in Issue Year 2024 Volume: 30 Issue: 2

Cite

APA Bayar, İ., & Akkoç, S. (2024). A Mini Review on Components of Flax Seed and Their Effects on Breast Cancer. Journal of Agricultural Sciences, 30(2), 205-215. https://doi.org/10.15832/ankutbd.1349777

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