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Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri

Year 2020, Volume: 2 Issue: 3, 158 - 174, 22.12.2020
https://doi.org/10.46413/boneyusbad.792458

Abstract

Turner Sendromu, gonozomlardaki X kromozomlarından birinin tam veya kısmi kaybı ya da 46,XY kromozomlu fetüslerde Y kromozomu kaybı sonucunda gelişen kromozomal bir bozukluktur. Turner Sendromlu olguların yaklaşık %50’sinde 45,X karyotip bulunmaktadır ve bu olguların çoğunda prematür ovaryen yetmezlik durumu mevcut olabilir. Olguların sadece %10’unda spontan pubertel gelişimin tamamlanabildiği ve %2’sinde spontan gebeliğin oluşabildiği bildirilmiştir. Turner Sendromu, üreme sistemi ve diğer sistemler üzerindeki etkileri düşünüldüğünde dikkatli bir şekilde ele alınması gereken önemli bir kromozomal anomalidir. Sendromun tipine bağlı olarak spontan menarş ve gebelik gelişebileceği gibi hormon replasmanı ve/veya yardımcı üreme teknikleri yardımıyla da fertilite sağlanabilmektedir. İnfertilite hemşirelerinin, yardımcı üreme teknikleri ile tedavi gören Turner Sendromlu bireylerin bilgi ihtiyaçlarını gidermeleri ve bireyleri gerekli psikolojik ve psikoseksüel destek alabilecekleri kaynaklara yönlendirmeleri gerekmektedir.

References

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  • Al Alwan, I., Khadora, M., Amir, I., Nasret, G., Omair, A., Brown, L., et al. (2014). Turner Syndrome Genotype and phenotype and their effect on presenting features and timing of Diagnosis. Int J Health Sci, 8 (2), 195-202.
  • Alvaro Mercadal, B., Imbert, R., Demeestere, I., Englert, Y., & Delbaere, A. (2011). Pregnancy outcome after oocyte donation in patients with Turner's syndrome and partial X monosomy. Hum Reprod, 26 (8), 2061-8.
  • Balen, A. H., Harris, S. E., Chambers, E. L., & Picton, H. M. (2010). Conservation of fertility and oocyte genetics in a young woman with mosaic Turner syndrome. BJOG, 117 (2), 238-42.
  • Bernard, V., Donadille, B., Zenaty, D., Courtillot, C., Salenave, S., Brac de la Perriere, A., et al. (2016). Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. Hum Reprod, 31 (4), 782-8.
  • Birkebaek, N. H., Cruger, D., Hansen, J., Nielsen, J., & Bruun-Petersen, G. (2002). Fertility and pregnancy outcome in Danish women with Turner syndrome. Clin Genet, 61 (1), 35-9.
  • Blair, J., Tolmie, J., Hollman, A. S., & Donaldson, M. D. (2001). Phenotype, ovarian function, and growth in patients with 45,X/47,XXX Turner mosaicism: implications for prenatal counseling and estrogen therapy at puberty. J Pediatr, 139 (5), 724-28.
  • Blumenthal, A. L., & Allanson, J. E. (1997). Turner syndrome in a mother and daughter: r(X) and fertility. Clin Genet, 52 (3), 187-91.
  • Bodri, D., Vernaeve, V., Figueras, F., Vidal, R., Guillén, J. J., & Coll, O. (2006). Oocyte donation in patients with Turner's syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy. Hum Reprod, 21 (3), 829-32.
  • Boivin, J. (2003). A review of psychosocial interventions in infertility. Soc Sci Me, 57 (12), 2325-41.
  • Bondy, C. A. (2007). Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab, 92 (1), 10-25.
  • Borgström, B., Hreinsson, J., Rasmussen, C., Sheikhi, M., Fried, G., Keros, V., et al. (2009). Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles. J Clin Endocrinol Metab, 94 (1), 74-80.
  • Broer, S. L., Broekmans, F. J., Laven, J. S., & Fauser, B. C. (2014). Anti-Mullerian hormone: ovarian reserve testing and its potential clinical implications. Hum Reprod Update, 20 (5), 688-701.
  • Bryman, I., Sylven, L., Berntorp, K., Innala, E., Bergstrom, I., Hanson, C., et al. (2011). Pregnancy rate and outcome in Swedish women with Turner syndrome. Fertil Steril, 95 (8), 2507-10.
  • Cadoret, F., Parinaud, J., Bettiol, C., Pienkowski, C., Letur, H., Ohl, J., et al. (2018). Pregnancy outcome in Turner syndrome: A French multi-center study after the 2009 guidelines. Eur J Obstet Gynecol Reprod Biol, 229, 20-25.
  • Costa, T., Lambert, M., Teshima, I., Ray, P. N., Richer, C. L., & Dallaire, L. (1998). Monozygotic twins with 45,X/46,XY mosaicism discordant for phenotypic sex. Am J Med Genet, 75 (1), 40-4.
  • Çeri, Ö., Yılmaz, A., & Soykan, A. (2008). Cinsel işlev bozuklukları. Türkiye Klinikleri J Psychiatry-Special Topics, 1 (2), 71-8.
  • Doğer, E., Çakıroğlu, Y., Ceylan, Y., Ulak, E., Özdamar, Ö., & Çalışkan, E. (2015). Reproductive and obstetric outcomes in mosaic Turner’s Syndrome: a cross-sectional study and review of the literature. Reproduc Biol Endocrinol, 13, 59.
  • Dolega, Z., Jez, W., & Irzyniec, T. (2014). The cohort effect in studies related to differences in psychosocial functioning of women with Turner syndrome. Endokrynol Pol, 65 (4), 287-94.
  • El-Shawarby, S.A., Sharif, F., Conway, G., Serhal, P., & Davies, M. (2010). Oocyte cryopreservation after controlled ovarian hyperstimulation in mosaic Turner syndrome: another fertility preservation option in a dedicated UK clinic. BJOG, 117 (2), 234-7.
  • Elsheikh, M., Dunger, D. B., Conway, G. S., & Wass, J. A. (2002). Turner's syndrome in adulthood. Endocrine Reviews, 23 (1), 120-40.
  • Ford, C. E., Jones, K. W., Polani, P. E., De Almeida, J. C., & Briggs, J. H. (1959). A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome). Lancet, 1 (7075):711-713.
  • Foudila, T., Söderström-Anttila, V., & Hovatta, O. (1999). Turner's syndrome and pregnancies after oocyte donation. Hum Reprod, 14 (2), 532-5.
  • Gil, M. M., Quezada, M. S., Revello, R., Akolekar, R., & Nicolaides, K. H. (2015). Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol, 45 (3), 249-266.
  • Glass, I. A., Rauen, K. A., Chen, E., Parkes, J., Alberston, D. G., Pinkel, D., et al. (2006). Ring chromosome 15: characterization by array CGH. Hum Genet, 118 (5), 611-617.
  • Göngör, İ., & Kızılkaya-Beji, N. (2015). İnfertilite hemşirelerinin gelişen rolleri ve sertifikasyon gereksinimi. F N Hem Derg, 23 (2), 152-9.
  • Gravholt CH. Epidemiological, endocrine and metabolic features in Turner syndrome. Eur J Endocrinol. 2004;151(6):657-87.
  • Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., et al. (2017). Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol, 177 (3), G1-70.
  • Grynberg, M., Bidet, M., Benard, J., Poulain, M., Sonigo, C., Cedrin-Durnerin, I., et al. (2016). Fertility preservation in Turner syndrome. Fertil Steril, 105 (1), 13-19.
  • Gunther, D. F., Eugster, E., Zagar, A. J., Bryant, C. G., Davenport, M. L., & Quigley, C. A. (2004). Ascertainment bias in Turner syndrome: new insights from girls who were diagnosed incidentally in prenatal life. Pediatrics, 114 (3), 640-644.
  • Hadnott, T. N., Gould, H. N., Gharib, A. M., & Bondy, C. A. (2011). Outcomes of spontaneous and assisted pregnancies in Turner syndrome: The U.S. National Institutes of Health experience. Fertil Steril, 95 (7), 2251-6.
  • Hagen, C. P., Aksglaede, L., Sorensen, K., Main, K. M., Boas, M., Cleemann, L., et al. (2010). Serum levels of anti-Mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients. J Clin Endocrinol Metab, 95 (11), 5003-10.
  • Hagen, C. P., Main, K. M., Kjaergaard, S., & Juul, A. (2010). FSH, LH, inhibin B and estradiol levels in Turner syndrome depend on age and karyotype: longitudinal study of 70 Turner girls with or without spontaneous puberty. Hum Reprod, 25 (12), 3134-41.
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Fertility Status in Turner Syndrome and The Roles of The Infertility Nurse

Year 2020, Volume: 2 Issue: 3, 158 - 174, 22.12.2020
https://doi.org/10.46413/boneyusbad.792458

Abstract

Turner Syndrome is a chromosomal disorder that develops as a result of the complete or partial loss of one of the X chromosomes in the gonosomes or the loss of the Y chromosome in fetuses with 46, XY chromosomes. Approximately 50% of the syndromed cases have 45, X karyotype and premature ovarian failure may be present in most of these cases. It has been reported that spontaneous pubertal development can be completed in only 10% of the cases and spontaneous pregnancy can occur in 2%. Turner Syndrome is an important chromosomal abnormality that should be handled carefully considering its effects on the reproductive system and other systems. Depending on the type of the syndrome, spontaneous menarche and pregnancy can develop, as well as fertility can be achieved with the help of hormone replacement and/or assisted reproductive techniques. Infertility nurses need to meet the information needs of individuals with Turner Syndrome who are treated with assisted reproductive techniques and direct them to the resources they can get necessary psychological and psychosexual support.

References

  • Adachi, M., Tachibana, K., Asakura, Y., Muroya, K., & Ogata, T. (2000). Del(X)(p21.1) in a mother and two daughters: genotype-phenotype correlation of Turner features. Hum Genet, 106, 306-10.
  • Al Alwan, I., Khadora, M., Amir, I., Nasret, G., Omair, A., Brown, L., et al. (2014). Turner Syndrome Genotype and phenotype and their effect on presenting features and timing of Diagnosis. Int J Health Sci, 8 (2), 195-202.
  • Alvaro Mercadal, B., Imbert, R., Demeestere, I., Englert, Y., & Delbaere, A. (2011). Pregnancy outcome after oocyte donation in patients with Turner's syndrome and partial X monosomy. Hum Reprod, 26 (8), 2061-8.
  • Balen, A. H., Harris, S. E., Chambers, E. L., & Picton, H. M. (2010). Conservation of fertility and oocyte genetics in a young woman with mosaic Turner syndrome. BJOG, 117 (2), 238-42.
  • Bernard, V., Donadille, B., Zenaty, D., Courtillot, C., Salenave, S., Brac de la Perriere, A., et al. (2016). Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. Hum Reprod, 31 (4), 782-8.
  • Birkebaek, N. H., Cruger, D., Hansen, J., Nielsen, J., & Bruun-Petersen, G. (2002). Fertility and pregnancy outcome in Danish women with Turner syndrome. Clin Genet, 61 (1), 35-9.
  • Blair, J., Tolmie, J., Hollman, A. S., & Donaldson, M. D. (2001). Phenotype, ovarian function, and growth in patients with 45,X/47,XXX Turner mosaicism: implications for prenatal counseling and estrogen therapy at puberty. J Pediatr, 139 (5), 724-28.
  • Blumenthal, A. L., & Allanson, J. E. (1997). Turner syndrome in a mother and daughter: r(X) and fertility. Clin Genet, 52 (3), 187-91.
  • Bodri, D., Vernaeve, V., Figueras, F., Vidal, R., Guillén, J. J., & Coll, O. (2006). Oocyte donation in patients with Turner's syndrome: a successful technique but with an accompanying high risk of hypertensive disorders during pregnancy. Hum Reprod, 21 (3), 829-32.
  • Boivin, J. (2003). A review of psychosocial interventions in infertility. Soc Sci Me, 57 (12), 2325-41.
  • Bondy, C. A. (2007). Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab, 92 (1), 10-25.
  • Borgström, B., Hreinsson, J., Rasmussen, C., Sheikhi, M., Fried, G., Keros, V., et al. (2009). Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles. J Clin Endocrinol Metab, 94 (1), 74-80.
  • Broer, S. L., Broekmans, F. J., Laven, J. S., & Fauser, B. C. (2014). Anti-Mullerian hormone: ovarian reserve testing and its potential clinical implications. Hum Reprod Update, 20 (5), 688-701.
  • Bryman, I., Sylven, L., Berntorp, K., Innala, E., Bergstrom, I., Hanson, C., et al. (2011). Pregnancy rate and outcome in Swedish women with Turner syndrome. Fertil Steril, 95 (8), 2507-10.
  • Cadoret, F., Parinaud, J., Bettiol, C., Pienkowski, C., Letur, H., Ohl, J., et al. (2018). Pregnancy outcome in Turner syndrome: A French multi-center study after the 2009 guidelines. Eur J Obstet Gynecol Reprod Biol, 229, 20-25.
  • Costa, T., Lambert, M., Teshima, I., Ray, P. N., Richer, C. L., & Dallaire, L. (1998). Monozygotic twins with 45,X/46,XY mosaicism discordant for phenotypic sex. Am J Med Genet, 75 (1), 40-4.
  • Çeri, Ö., Yılmaz, A., & Soykan, A. (2008). Cinsel işlev bozuklukları. Türkiye Klinikleri J Psychiatry-Special Topics, 1 (2), 71-8.
  • Doğer, E., Çakıroğlu, Y., Ceylan, Y., Ulak, E., Özdamar, Ö., & Çalışkan, E. (2015). Reproductive and obstetric outcomes in mosaic Turner’s Syndrome: a cross-sectional study and review of the literature. Reproduc Biol Endocrinol, 13, 59.
  • Dolega, Z., Jez, W., & Irzyniec, T. (2014). The cohort effect in studies related to differences in psychosocial functioning of women with Turner syndrome. Endokrynol Pol, 65 (4), 287-94.
  • El-Shawarby, S.A., Sharif, F., Conway, G., Serhal, P., & Davies, M. (2010). Oocyte cryopreservation after controlled ovarian hyperstimulation in mosaic Turner syndrome: another fertility preservation option in a dedicated UK clinic. BJOG, 117 (2), 234-7.
  • Elsheikh, M., Dunger, D. B., Conway, G. S., & Wass, J. A. (2002). Turner's syndrome in adulthood. Endocrine Reviews, 23 (1), 120-40.
  • Ford, C. E., Jones, K. W., Polani, P. E., De Almeida, J. C., & Briggs, J. H. (1959). A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome). Lancet, 1 (7075):711-713.
  • Foudila, T., Söderström-Anttila, V., & Hovatta, O. (1999). Turner's syndrome and pregnancies after oocyte donation. Hum Reprod, 14 (2), 532-5.
  • Gil, M. M., Quezada, M. S., Revello, R., Akolekar, R., & Nicolaides, K. H. (2015). Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol, 45 (3), 249-266.
  • Glass, I. A., Rauen, K. A., Chen, E., Parkes, J., Alberston, D. G., Pinkel, D., et al. (2006). Ring chromosome 15: characterization by array CGH. Hum Genet, 118 (5), 611-617.
  • Göngör, İ., & Kızılkaya-Beji, N. (2015). İnfertilite hemşirelerinin gelişen rolleri ve sertifikasyon gereksinimi. F N Hem Derg, 23 (2), 152-9.
  • Gravholt CH. Epidemiological, endocrine and metabolic features in Turner syndrome. Eur J Endocrinol. 2004;151(6):657-87.
  • Gravholt, C. H., Andersen, N. H., Conway, G. S., Dekkers, O. M., Geffner, M. E., Klein, K. O., et al. (2017). Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting. Eur J Endocrinol, 177 (3), G1-70.
  • Grynberg, M., Bidet, M., Benard, J., Poulain, M., Sonigo, C., Cedrin-Durnerin, I., et al. (2016). Fertility preservation in Turner syndrome. Fertil Steril, 105 (1), 13-19.
  • Gunther, D. F., Eugster, E., Zagar, A. J., Bryant, C. G., Davenport, M. L., & Quigley, C. A. (2004). Ascertainment bias in Turner syndrome: new insights from girls who were diagnosed incidentally in prenatal life. Pediatrics, 114 (3), 640-644.
  • Hadnott, T. N., Gould, H. N., Gharib, A. M., & Bondy, C. A. (2011). Outcomes of spontaneous and assisted pregnancies in Turner syndrome: The U.S. National Institutes of Health experience. Fertil Steril, 95 (7), 2251-6.
  • Hagen, C. P., Aksglaede, L., Sorensen, K., Main, K. M., Boas, M., Cleemann, L., et al. (2010). Serum levels of anti-Mullerian hormone as a marker of ovarian function in 926 healthy females from birth to adulthood and in 172 Turner syndrome patients. J Clin Endocrinol Metab, 95 (11), 5003-10.
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There are 73 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section REVIEW ARTICLE
Authors

Meryem Öngen 0000-0001-8708-3336

Fatma Başar 0000-0003-4288-9111

Publication Date December 22, 2020
Submission Date September 9, 2020
Acceptance Date November 2, 2020
Published in Issue Year 2020 Volume: 2 Issue: 3

Cite

APA Öngen, M., & Başar, F. (2020). Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi, 2(3), 158-174. https://doi.org/10.46413/boneyusbad.792458
AMA Öngen M, Başar F. Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. December 2020;2(3):158-174. doi:10.46413/boneyusbad.792458
Chicago Öngen, Meryem, and Fatma Başar. “Turner Sendromunda Fertilite Durumu Ve İnfertilite Hemşiresinin Rolleri”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi 2, no. 3 (December 2020): 158-74. https://doi.org/10.46413/boneyusbad.792458.
EndNote Öngen M, Başar F (December 1, 2020) Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 2 3 158–174.
IEEE M. Öngen and F. Başar, “Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri”, Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi, vol. 2, no. 3, pp. 158–174, 2020, doi: 10.46413/boneyusbad.792458.
ISNAD Öngen, Meryem - Başar, Fatma. “Turner Sendromunda Fertilite Durumu Ve İnfertilite Hemşiresinin Rolleri”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi 2/3 (December 2020), 158-174. https://doi.org/10.46413/boneyusbad.792458.
JAMA Öngen M, Başar F. Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2020;2:158–174.
MLA Öngen, Meryem and Fatma Başar. “Turner Sendromunda Fertilite Durumu Ve İnfertilite Hemşiresinin Rolleri”. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri Ve Araştırmaları Dergisi, vol. 2, no. 3, 2020, pp. 158-74, doi:10.46413/boneyusbad.792458.
Vancouver Öngen M, Başar F. Turner Sendromunda Fertilite Durumu ve İnfertilite Hemşiresinin Rolleri. Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi. 2020;2(3):158-74.

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