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The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight

Year 2024, Volume: 14 Issue: 1, 273 - 282, 28.03.2024
https://doi.org/10.33808/clinexphealthsci.1218885

Abstract

Capsicum plant consists of savage and tame types, and there is a substance named the capsaicin that causes burning sensation of the bitter peppers. Capsaicin has many effects in the body. In addition to its antioxidant and anti-inflammatory properties, it has benefits such as cancer prevention, reducing blood pressure, having analgesic effects in the body. There are different capsaicinoids such as dihydrocapsaicin, nordroydrocapsaicin, homocapsaicin in nature. These capsaicinoids provide anti cancer activities by interacting with key signal molecules. Capsaicin can suppress the growth of cancer cells by changing the expression of the relevant genes of cancer cells. In summary, the capsaicin
ensures anticancer activity by suppressing the proliferation, growth in cancer cells and to induce apoptosis which inhibit the metastasis. This situation can provide promising new treatment approaches in common and fatal cancer species today. This article revises the relationship between capsaicin and different types of cancer, anti cancer effect of capsaicin. Therewithal, studies examining the treatment of different cancer cells with various doses of capsaicin are included. Capsaicin can suppress the growth of cancer cells by changing the expression of the relevant genes of cancer cells.

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References

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Year 2024, Volume: 14 Issue: 1, 273 - 282, 28.03.2024
https://doi.org/10.33808/clinexphealthsci.1218885

Abstract

Project Number

-

References

  • Chapa-Oliver AM, Mejía-Teniente L. Capsaicin: From plants to a cancer-suppressing agent. Molecules. 2016;21:931. DOI: 10.3390/molecules21080931
  • Kehie M, Kumaria S, Tandon P. Manipulation of culture strategies to enhance capsaicin biosynthesis in suspension and immobilized cell cultures of Capsicum chinense Jacq. cv. Naga King Chili. Bioprocess Biosyst Eng. 2014;37:1055-1063. DOI: 10.1007/s00449-013-1076-2
  • Srinivasan K. Biological activities of red pepper (Capsicum annuum) and its pungent principle capsaicin: a review. Crit Rev Food Sci Nut. 2016;56:1488-1500. DOI: 10.1080/10408398.2013.772090
  • Lu M, Chen C, Lan Y, Xiao J, Li R, Huang J, Ho CT. Capsaicin—the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems. Food Funct. 2020;11:2848-2860. DOI: 10.1039/D0FO00351D
  • Prasad BCN, Shrivastava R, Ravishankar GA. Capsaicin. Evid-Based-Integrative-Med. 2005;2:147-166. DOI: 10.2165/01197065-20050203000006
  • Wang F, Xue Y, Fu L, Wang Y, He M, Zhao L, Liao X. Extraction, purification, bioactivity and pharmacological effects of capsaicin: a review. Crit Rev Food Sci Nut. 2021;1-29. DOI: 10.1080/10408398.2021.1884840
  • Basith S, Cui M, Hong S, Choi S. Harnessing the therapeutic potential of capsaicin and its analogues in pain and other diseases. Molecules. 2016; 21:966. DOI: 10.3390/molecules21080966
  • Malmberg AB, Bley KR. Turning up the heat on pain: TRPV1 receptors in pain and inflammation. Springer Science & Business Media; 2005.
  • Friedman JR, Nolan NA, Brown KC, Miles SL, Akers AT, Colclough KW, Dasgupta P. Anticancer activity of natural and synthetic capsaicin analogs. J Pharmacol Exp Ther. 2018;364:462-473. DOI: 10.1124/jpet.117.243691
  • Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Mantyh PW. Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain. J Neurosci. 2005;25:3126-3131. DOI: 10.1523/JNEUROSCI.3815-04.2005
  • Zhang S, Wang D, Huang J, Hu Y, Xu Y. Application of capsaicin as a potential new therapeutic drug in human cancers. J Clin Pharm Ther. 2020;45:16-28. DOI: 10.1111/jcpt.13039
  • Sung H, Ferlay J, Siegel RL, Laversanne M. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209-249. DOI: 10.3322/caac.21660
  • Clark R, Lee SH. Anticancer properties of capsaicin against human cancer. Anticancer Res. 2016;36:837-843.
  • Fernandes ES, Cerqueira ARA, Soares AG, Costa SK. Capsaicin and its role in chronic diseases. Adv Exp Med Biol. 2016;91-125. DOI: 10.1007/978-3-319-41342-6_5
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  • Arzuman L, Beale P, Yu JQ, Huq F. Synthesis of tris (quinoline) monochloroplatinum (II) chloride and its activity alone and in combination with capsaicin and curcumin in human ovarian Cancer cell lines. Anticancer Res. 2016;36(6):2809-2818.
  • Vendrely V, Peuchant E, Buscail E, Moranvillier I, Rousseau B, Bedel A, Brillac A, de Verneuil H, Moreau-Gaudry F, Dabernat S. Resveratrol and capsaicin used together as food complements reduce tumor growth and rescue full efficiency of low dose gemcitabine in a pancreatic cancer model. Cancer Lett. 2017;390:91-102. DOI: 10.1016/j.canlet.2017.01.002
  • Silva R, Vilas-Boas V, Carmo H, Dinis-Oliveira RJ, Carvalho F, de Lourdes Bastos M, Remião F. Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy. Pharmacol Ther. 2015;149:1-123. DOI: 10.1016/j.pharmthera.2014.11.013
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There are 88 citations in total.

Details

Primary Language English
Subjects Nutritional Science
Journal Section Review
Authors

Nevin Şanlıer 0000-0001-5937-0485

Esra Irmak 0000-0001-5602-9468

Zeynep Bengisu Ejder 0000-0001-7231-8497

Project Number -
Early Pub Date March 23, 2024
Publication Date March 28, 2024
Submission Date December 14, 2022
Published in Issue Year 2024 Volume: 14 Issue: 1

Cite

APA Şanlıer, N., Irmak, E., & Ejder, Z. B. (2024). The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight. Clinical and Experimental Health Sciences, 14(1), 273-282. https://doi.org/10.33808/clinexphealthsci.1218885
AMA Şanlıer N, Irmak E, Ejder ZB. The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight. Clinical and Experimental Health Sciences. March 2024;14(1):273-282. doi:10.33808/clinexphealthsci.1218885
Chicago Şanlıer, Nevin, Esra Irmak, and Zeynep Bengisu Ejder. “The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight”. Clinical and Experimental Health Sciences 14, no. 1 (March 2024): 273-82. https://doi.org/10.33808/clinexphealthsci.1218885.
EndNote Şanlıer N, Irmak E, Ejder ZB (March 1, 2024) The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight. Clinical and Experimental Health Sciences 14 1 273–282.
IEEE N. Şanlıer, E. Irmak, and Z. B. Ejder, “The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight”, Clinical and Experimental Health Sciences, vol. 14, no. 1, pp. 273–282, 2024, doi: 10.33808/clinexphealthsci.1218885.
ISNAD Şanlıer, Nevin et al. “The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight”. Clinical and Experimental Health Sciences 14/1 (March 2024), 273-282. https://doi.org/10.33808/clinexphealthsci.1218885.
JAMA Şanlıer N, Irmak E, Ejder ZB. The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight. Clinical and Experimental Health Sciences. 2024;14:273–282.
MLA Şanlıer, Nevin et al. “The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight”. Clinical and Experimental Health Sciences, vol. 14, no. 1, 2024, pp. 273-82, doi:10.33808/clinexphealthsci.1218885.
Vancouver Şanlıer N, Irmak E, Ejder ZB. The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight. Clinical and Experimental Health Sciences. 2024;14(1):273-82.

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