The Relationship Between Capsaicin in Chili Pepper and Cancer: A Comprehensive Insight

Year 2024, Volume: 14 Issue: 1, 273 - 282, 28.03.2024

Nevin Şanlıer , Esra Irmak , Zeynep Bengisu Ejder

https://doi.org/10.33808/clinexphealthsci.1218885

Cited By: 1

Abstract

Capsicum plant consists of savage and tame types, and there is a substance named the capsaicin that causes burning sensation of the bitter peppers. Capsaicin has many effects in the body. In addition to its antioxidant and anti-inflammatory properties, it has benefits such as cancer prevention, reducing blood pressure, having analgesic effects in the body. There are different capsaicinoids such as dihydrocapsaicin, nordroydrocapsaicin, homocapsaicin in nature. These capsaicinoids provide anti cancer activities by interacting with key signal molecules. Capsaicin can suppress the growth of cancer cells by changing the expression of the relevant genes of cancer cells. In summary, the capsaicin
ensures anticancer activity by suppressing the proliferation, growth in cancer cells and to induce apoptosis which inhibit the metastasis. This situation can provide promising new treatment approaches in common and fatal cancer species today. This article revises the relationship between capsaicin and different types of cancer, anti cancer effect of capsaicin. Therewithal, studies examining the treatment of different cancer cells with various doses of capsaicin are included. Capsaicin can suppress the growth of cancer cells by changing the expression of the relevant genes of cancer cells.

Keywords

capsaicin, cancer, TRPV1, anticancer, chili pepper

Supporting Institution

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Thanks

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