Case Report
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A case of primary Ewing sarcoma presenting with a vulvar mass

Year 2023, Volume: 3 Issue: 2, 52 - 55, 30.12.2023

Abstract

Ewing sarcoma/Primitive Neuroectodermal Tumor (ES/PNET) is a high-grade malignant neoplasm that often arises from the skeletal system. Primary extraosseous ES/PNET is a condition that rarely affects the female genital system. Few cases of primary vulvar and vaginal ES have been published to date. In this article, an 11-year-old case of primary ES, one of the youngest cases in the literature, originating from the labium majus and treated successfully with multidisciplinary treatment, is presented.

References

  • Ewing J. The Classic: Diffuse endothelioma of bone. Proceedings of the New York Pathological Society. 1921;12:17. Clin Orthop Relat Res. 2006;450:25-7.
  • Lessnick SL, Grohar PJ, DuBois SG, Hogendoorn PCW, Davidson D, Laack NN et al. Ewing Sarcoma. In Pizzo and Poplack’s Pediatric Oncology, 8th ed. (Eds SM Blaney, LJ Helman, PC Adamson):747-69 Philadelphia: Wolters Kluwer. 2021.
  • Rud NP, Reiman HM, Pritchard DJ, Frassica FJ, Smithson WA. Extraosseous Ewing’s sarcoma. A study of 42 cases. Cancer. 1989;64:1548–53.
  • Cesari M, Righi A, Cevolani L, Palmerini E, Vanel D, Donati DM et al. Ewing sarcoma in patients over 40 years of age: a prospective analysis of 31 patients treated at a single institution. Tumori J. 2016;102:481–7.
  • Applebaum MA, Worch J, Matthay KK, Goldsby R, Neuhaus J, West DC et al. Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer. 2011;117:3027–32.
  • Ghandour M, Semaan K, Saad E, Horsch A, Abdallah R, Semaan D. Clinicodemographic characteristics of extraosseous ewing sarcoma: A comparative meta-analysis of pediatric and adult patients. J Orthop. 2023;44:86-92.
  • Ghandour M, Lehner B, Klotz M, Geisbüsch A, Bollmann J, Renkawitz T et al. Extraosseous Ewing sarcoma in children: a systematic review and meta-analysis of clinicodemographic characteristics. Children (Basel). 2022;9:1859.
  • Yang J, Guo Q, Yang Y, Zhang J, Lang J, Shi H. Primary vulvar Ewing sarcoma/primitive neuroectodermal tumor: a report of one case and review of the literature. J Pediatr Adolesc Gynecol. 2012;25:e93-7.
  • Halil S, Kucuk M, Arvas M, Aydin O, Calay ZZ. Peripheral primitive neuroectodermal tumor (PNET) of the vulva: a case report. Eur J Gynaecol Oncol. 2011;32:117-8.
  • Tanaka K, Ozaki T. New TNM classification (AJCC eighth edition) of bone and soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group. Jpn J Clin Oncol. 2019;49:103-7.
  • Juergens C, Weston C, Lewis I, Whelan J, Paulussen M, Oberlin O et al. Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. Pediatr Blood Cancer. 2006;47:22-9.
  • Özkan A, Bayram İ, Sezgin G, Mirioğlu A, Küpeli S. Efficacy of replacing actinomycin-D with carboplatin in Ewing sarcoma consolidation treatment: Single-center experience. J Bone Oncol. 2022;35:100435.
  • Tunitsky-Bitton E, Uy-Kroh MJ, Michener C, Tarr ME. Primary Ewing sarcoma presenting as a vulvar mass in an adolescent: case report and review of literature. J Pediatr Adolesc Gynecol. 2015;28:e179-83.
  • El Housheimi A, Khalil A, Khalifeh D, Berjawi G, Seoud M, Tabbarah A et al. Primary vulvar Ewing sarcoma/peripheral primitive neuroectodermal tumor with pelvic lymph nodes metastasis: A case report and review of literature. J Obstet Gynaecol Res. 2020;46:2185-92.
  • Tunitsky E, Goldman HB, Ridgeway B. Periurethral mass: a rare and puzzling entity. Obstet Gynecol. 2012;120:1459-64.
  • Zizi-Sermpetzoglou A, Petrakopoulou N, Tepelenis N, Savvaidou V, Vasilakaki T. Intravascular T-cell lymphoma of the vulva, CD30 positive: a case report. Eur J Gynaecol Oncol. 2009;30:586-8.
  • Diniz da Costa AT, Coelho AM, Lourenço AV, Bernardino M, Ribeirinho AL, Jorge CC. Primary breast cancer of the vulva: a case report. J Low Genit Tract Dis. 2012;16:155-7.
  • Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T et al. Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t (11;22) translocation breakpoints. Genes Chromosomes Cancer. 1992;5:271-7.
  • Friedman DN, Chastain K, Chou JF, Moskowitz CS, Adsuar R, Wexler LH et al. Morbidity and mortality after treatment of Ewing sarcoma: A single-institution experience. Pediatr Blood Cancer. 2017;64:e26562.
  • Raciborska A, Bilska K, Drabko K, Chaber R, Sobol G, Pogorzała M et al. Validation of a multi-modal treatment protocol for Ewing sarcoma--a report from the polish pediatric oncology group. Pediatr Blood Cancer. 2014;61:2170-4.
  • Esiashvili N, Goodman M, Marcus Jr RB. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol. 2008;30:425-30.

Vulvada kitle ile başvuran primer Ewing sarkom olgusu

Year 2023, Volume: 3 Issue: 2, 52 - 55, 30.12.2023

Abstract

Ewing sarkomu/Primitif Nöroektodermal tümör (ES/PNET), sıklıkla iskelet sisteminden gelişen, yüksek dereceli malign bir neoplazmdır. Primer ekstraosseöz ES/PNET, kadın genital sistemini nadiren etkileyen bir durumdur. Bugüne kadar az sayıda primer vulvar ve vajinal ES vakası yayınlanmıştır. Bu yazıda, labium majus bölgesinden kaynaklanan ve multidisipliner tedavi ile başarılı bir şekilde tedavi edilen literatürün en genç vakalarından biri olan 11 yaşında bir primer ES olgusu sunulmuştur.

References

  • Ewing J. The Classic: Diffuse endothelioma of bone. Proceedings of the New York Pathological Society. 1921;12:17. Clin Orthop Relat Res. 2006;450:25-7.
  • Lessnick SL, Grohar PJ, DuBois SG, Hogendoorn PCW, Davidson D, Laack NN et al. Ewing Sarcoma. In Pizzo and Poplack’s Pediatric Oncology, 8th ed. (Eds SM Blaney, LJ Helman, PC Adamson):747-69 Philadelphia: Wolters Kluwer. 2021.
  • Rud NP, Reiman HM, Pritchard DJ, Frassica FJ, Smithson WA. Extraosseous Ewing’s sarcoma. A study of 42 cases. Cancer. 1989;64:1548–53.
  • Cesari M, Righi A, Cevolani L, Palmerini E, Vanel D, Donati DM et al. Ewing sarcoma in patients over 40 years of age: a prospective analysis of 31 patients treated at a single institution. Tumori J. 2016;102:481–7.
  • Applebaum MA, Worch J, Matthay KK, Goldsby R, Neuhaus J, West DC et al. Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer. 2011;117:3027–32.
  • Ghandour M, Semaan K, Saad E, Horsch A, Abdallah R, Semaan D. Clinicodemographic characteristics of extraosseous ewing sarcoma: A comparative meta-analysis of pediatric and adult patients. J Orthop. 2023;44:86-92.
  • Ghandour M, Lehner B, Klotz M, Geisbüsch A, Bollmann J, Renkawitz T et al. Extraosseous Ewing sarcoma in children: a systematic review and meta-analysis of clinicodemographic characteristics. Children (Basel). 2022;9:1859.
  • Yang J, Guo Q, Yang Y, Zhang J, Lang J, Shi H. Primary vulvar Ewing sarcoma/primitive neuroectodermal tumor: a report of one case and review of the literature. J Pediatr Adolesc Gynecol. 2012;25:e93-7.
  • Halil S, Kucuk M, Arvas M, Aydin O, Calay ZZ. Peripheral primitive neuroectodermal tumor (PNET) of the vulva: a case report. Eur J Gynaecol Oncol. 2011;32:117-8.
  • Tanaka K, Ozaki T. New TNM classification (AJCC eighth edition) of bone and soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group. Jpn J Clin Oncol. 2019;49:103-7.
  • Juergens C, Weston C, Lewis I, Whelan J, Paulussen M, Oberlin O et al. Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. Pediatr Blood Cancer. 2006;47:22-9.
  • Özkan A, Bayram İ, Sezgin G, Mirioğlu A, Küpeli S. Efficacy of replacing actinomycin-D with carboplatin in Ewing sarcoma consolidation treatment: Single-center experience. J Bone Oncol. 2022;35:100435.
  • Tunitsky-Bitton E, Uy-Kroh MJ, Michener C, Tarr ME. Primary Ewing sarcoma presenting as a vulvar mass in an adolescent: case report and review of literature. J Pediatr Adolesc Gynecol. 2015;28:e179-83.
  • El Housheimi A, Khalil A, Khalifeh D, Berjawi G, Seoud M, Tabbarah A et al. Primary vulvar Ewing sarcoma/peripheral primitive neuroectodermal tumor with pelvic lymph nodes metastasis: A case report and review of literature. J Obstet Gynaecol Res. 2020;46:2185-92.
  • Tunitsky E, Goldman HB, Ridgeway B. Periurethral mass: a rare and puzzling entity. Obstet Gynecol. 2012;120:1459-64.
  • Zizi-Sermpetzoglou A, Petrakopoulou N, Tepelenis N, Savvaidou V, Vasilakaki T. Intravascular T-cell lymphoma of the vulva, CD30 positive: a case report. Eur J Gynaecol Oncol. 2009;30:586-8.
  • Diniz da Costa AT, Coelho AM, Lourenço AV, Bernardino M, Ribeirinho AL, Jorge CC. Primary breast cancer of the vulva: a case report. J Low Genit Tract Dis. 2012;16:155-7.
  • Zucman J, Delattre O, Desmaze C, Plougastel B, Joubert I, Melot T et al. Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t (11;22) translocation breakpoints. Genes Chromosomes Cancer. 1992;5:271-7.
  • Friedman DN, Chastain K, Chou JF, Moskowitz CS, Adsuar R, Wexler LH et al. Morbidity and mortality after treatment of Ewing sarcoma: A single-institution experience. Pediatr Blood Cancer. 2017;64:e26562.
  • Raciborska A, Bilska K, Drabko K, Chaber R, Sobol G, Pogorzała M et al. Validation of a multi-modal treatment protocol for Ewing sarcoma--a report from the polish pediatric oncology group. Pediatr Blood Cancer. 2014;61:2170-4.
  • Esiashvili N, Goodman M, Marcus Jr RB. Changes in incidence and survival of Ewing sarcoma patients over the past 3 decades: surveillance epidemiology and end results data. J Pediatr Hematol Oncol. 2008;30:425-30.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Pediatric Hematology and Oncology
Journal Section Case Report
Authors

Ezgi Ada Kaya 0009-0006-8318-1477

Ayşe Özkan 0000-0003-1181-8169

Publication Date December 30, 2023
Submission Date November 15, 2023
Acceptance Date December 8, 2023
Published in Issue Year 2023 Volume: 3 Issue: 2

Cite

AMA Kaya EA, Özkan A. Vulvada kitle ile başvuran primer Ewing sarkom olgusu. Çukurova Tıp Öğrenci Derg. December 2023;3(2):52-55.