İnsan immun yetmezlik virüsü ile yaşayan kişilerde adrenal bezin morfometrik analizi

Year 2024, Volume: 49 Issue: 1, 159 - 169, 29.03.2024

Ayşe Gül Kabakcı Ferit Kuşcu Ferhat Can Pişkin Yeşim Taşova Memduha Gülhal Bozkır

https://doi.org/10.17826/cumj.1391874

Abstract

Amaç: İnsan immün yetmezlik virüsü (HIV) enfeksiyonunun adrenal bez morfometrisi üzerine etkisini yaş, cinsiyet, vücut ağırlığı, hayatta kalma durumu ve CD4/CD8 parametrelerine göre değerlendirmeyi amaçladık.
Gereç ve Yöntem: Bu çalışmada, 2008 ve 2020 yılları arasında herhangi bir nedenle görüntülemesi olan 160 HIV enfeksiyonu ile yaşayan kişinin BT (130 erkek ve 30 kadın) arşivi tarandı. BT görüntüleri üzerinde planlanan anatomik ölçümler yapıldı. İnsan immün yetmezlik virüsü taşıyan kişilerin yaşları, takip süreleri, vücut ağırlıkları, boyları, CD4 ve CD8 değerleri, kişilerin BT incelemeleri ile eş zamanlı olarak elde edildi. Anatomik ölçüm olarak adrenal bez şekilleri, uzunluğu, corpus kalınlığı, medial kalınlığı, lateral kalınlığı, komşu anatomik yapılara (özefagus, columna vertebralis, vena cava inferior, aorta abdominalis ve diyafragma) uzaklığı değerlendirildi.
Bulgular: Çalışmamıza, yaş ortalaması 40,29±13,19 (erkek: 39,78±12,50, kadın: 42,53±15,88) olan, vücut ağırlığı ve boy uzunluğu sırasıyla kadınlarda, 67,04±18,10 kg ve 157,92±6,21 cm, erkeklerde ise 77.06±12.93 kg ve 171.67±8.97 cm olan HIV enfeksiyonu ile yaşayan kişiler dahil edildi. Anatomik ölçüm olarak adrenal bezin uzunluğu, corpus kalınlığı, medial crus kalınlığı, lateral crus kalınlığı, ösefagus’a, columna vertebralis’e, vena cava inferior’a, aorta abdominalis’e ve diyafragma’ya uzaklığı sırasıyla sağda; 4.77±1.70 cm, 3.59±1.23 mm, 2.76±0.83 mm, 2.79±0.87 mm, 3.21±1.21 cm, 1.45±0.85 cm, 0.92±0.57 cm, 2.41±0.65 cm, 1.57±0.84 cm ve solda; 5.78±2.8 cm, 3.77±1.43 mm, 3.38±1.17 mm, 2.92±1.06 mm, 3.10±1.26 cm, 2.11±0.7 cm, 4.10±0.83 cm, 0.90±0.45 cm, 1.21±0.73 cm olarak bulundu. En yaygın görülen adrenal bez tipi ise Y olarak kaydedildi. Ayrıca CD4 ve CD8 ortalama değerlerini sırasıyla 322,66±309,35 ve 1024,48 ±930,15 olarak bulundu.
Sonuç: HIV’le yaşayan kişilerin adrenal bezine ait bazı anatomik ölçümlerin yaş, cinsiyet, vücut ağırlığı, hayatta kalım durumu ve CD4/CD8 parametrelerinden etkilenebildiğini bulduk.

Keywords

Adrenal bez, adrenal yetmezlik, anatomi, insan immün yetmezlik virüsü

Ethical Statement

Ethical approval were obtained from Cukurova University Medical Faculty, Non-invasive clinical research Ethic Board with conclusion number 115/17.

Supporting Institution

none

Thanks

none

Morphometric analysis of adrenal gland in people living with human immunodeficiency virus

Abstract

Purpose: We aimed to evaluate the effect of Human Immunodeficiency Virus (HIV) infection on adrenal gland morphometry according to age, gender, body weight, survival status and CD4/CD8 parameters.
Materials and Methods: In this study, the CT archives (130 men and 30 women) of 160 people living with HIV infection who had imaging for any reason between 2008 and 2020 were scanned. Ages, years of follow-up, body weights, heights, CD4 and CD8 values of people with human immunodeficiency virus were obtained simultaneously with the CT examinations of the people. Anatomical measurements, adrenal gland shapes, length, corpus thickness, medial thickness, lateral thickness, distance to next anatomical structures (esophagus, vertebral column, vena cava inferior, aorta abdominalis and diaphragm) were evaluated.
Results: In our study, the average age was 40.29±13.19 (male: 39.78±12.50, female: 42.53±15.88), body weight and height were respectively 67.04±18.10 kg 157.92±6.21 cm in women and 77.06±12.93 kg, 171.67±8.97 cm in men, living with HIV infection were included. As anatomical measurements, the length, corpus thickness, medial crus thickness, lateral crus thickness, distance to the esophagus, columna vertebralis, vena cava inferior, aorta abdominalis and diaphragm of the adrenal gland were found respectively on the right; 4.77±1.70 cm, 3.59±1.23 mm, 2.76±0.83 mm, 2.79±0.87 mm, 3.21±1.21 cm, 1.45±0.85 cm, 0.92±0.57 cm, 2.41±0.65 cm, 1.57±0.84 cm and on the left; 5.78±2.8 cm, 3.77±1.43 mm, 3.38±1.17 mm, 2.92±1.06 mm, 3.10±1.26 cm, 2.11±0.7 cm, 4.10±0.83 cm, 0.90±0.45 cm, 1.21±0.73 cm. The most common adrenal gland type was recorded as Y. Additionally, the mean values of CD4 and CD8 were found to be 322.66±309.35 and 1024.48±930.15, respectively.
Conclusion: Some anatomical measurements of the adrenal gland of people living with HIV can be affected by age, gender, body weight, survival status and CD4/CD8 parameters.

Keywords

Adrenal gland, adrenal insufficiency, anatomy, human immunodeficiency virüs

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