Sesame
oil (SO) is a component of the traditional health food in India as well as in
oriental countries and has long been thought to possess the ability to prevent
various diseases. We examined the protective effects of sesame oil against
acute gastric mucosal damage induced in rats by nonsteroidal anti-inflammatory
drug indomethacin (IND). We also intended to determine the relation between
antiulcer effect of SO and its antioxidant properties by biochemical
evaluation. In this study a total of 5 rat groups were used for ulcer
experiment. Antiulcer effects of SO have been investigated on 24 hour fasted 5
rat groups with indomethacine (IND)-induced ulcer model in the presence of
positive (Famotidine, FAM), negative (untreated IND group) and intact control
groups. In ulcer experiments, two doses of SO exerted significant
anti-ulcerogenic effects. In gastric tissues, sesame oil administration
decreased the level of LPO and activities of CAT, GR, MPO which were increased
after IND application. Furthermore, SO increased the level of GSH which
decreased in ulcerous stomach tissues when compared to healthy rat group. We
determined that SO has anti-ulcerative effect and this effect are related to
antioxidative properties of sesame oil.
Primary Language | English |
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Subjects | Food Engineering |
Journal Section | Article |
Authors | |
Publication Date | December 29, 2018 |
Published in Issue | Year 2018 Volume: 2 Issue: 2 |
Eurasian Journal of Food Science and Technology (EJFST) e-ISSN: 2667-4890 Web: https://dergipark.org.tr/en/pub/ejfst e-mail: foodsciencejournal@gmail.com