Kedilerde Uzun Kemik Kırıklarının İyileşmesinde Otolog Trombositten Zengin Plazmanın (PRP) Terapötik Etkisinin Değerlendirilmesi

Year 2025, Volume: 22 Issue: 1, 36 - 44, 18.04.2025

Nail Deniz Yaşrın , İrem Ergin

https://doi.org/10.32707/ercivet.1610440

Abstract

Bu çalışmada, kedilerde uzun kemik kırıklarının iyileşmesi üzerine trombositten zengin plazmanın (PRP) klinik ve radyografik etkileri değerlendirildi. Çalışma iki gruptan oluştu: kontrol grubu (n= 11) ve PRP grubu (n= 11). Kontrol grubunda sadece osteosentez yapılırken, PRP grubuna osteosentez bölgesine jelatin sünger ile kombine edilen PRP uygulandı. Klinik ve radyografik değerlendirmeler 0. (preoperatif), 15. ve 30. (postoperatif) günlerde yapıldı. Klinik değerlendirme topallık skorlamasını içerirken, radyografik değerlendirme Hammer skalasına göre kırık iyileşmesi, kırık redüksiyonu, intramedüller pin konumlandırması ve kallus oluşumuna odaklandı. Her iki grupta da 15. ve 30. günlerde topallık skorlamasında anlamlı bir azalma gözlendi. 15. ve 30. günlerde gruplar arasında istatistiksel olarak anlamlı bir fark saptanmasa da, PRP grubunda daha düşük skorlama elde edildi. Gruplar arasında postoperatif 15. ve 30. gün zaman noktalarında kallus oluşumu ve kırık hattı skorlarında istatistiksel olarak anlamlı bir fark gözlenmedi. Ancak, kaynama skoru incelendiğinde, iki zaman dilimi arasında gözlenen farkın istatistiksel olarak anlamlı olduğu, PRP grubunda 15. günde daha belirgin bir etki olduğu bulundu. Sonuç olarak, çalışma sırasında herhangi bir komplikasyon gözlenmedi. PRP’nin, kedilerde uzun kemik diafiz kırıklarının genel klinik iyileşme sürecini önemli ölçüde değiştirmezken, erken dönemde, yangı fazında iyileşmeyi hızlandırdığı ve topallamayı azalttığı görüldü.

Keywords

Büyüme faktörü, felin, intramedullar pin, kallus, trombosit

Ethical Statement

Bu çalışma Ankara Üniversitesi Hayvan Deneyleri Yerel Etik Kurulunun 04.03.2020 tarihli toplantısında 2020-5-34 karar no ile onaylanmıştır.

Supporting Institution

Bu çalışma Ankara Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü tarafından desteklenmiştir (proje no: 147).

Evaluating the Therapeutic Impact of Autologous Platelet-Rich Plasma (PRP) on Long Bone Fracture Healing in Cats

Abstract

This study evaluated the clinical and radiographic effects of platelet-rich plasma (PRP) on the healing of long bone fractures in cats. It featured a control group (n= 11) and a PRP group (n= 11). In the control group, only osteosynthesis was performed, whereas the PRP group received a combination of PRP and a gelatin sponge applied to the osteosynthesis site. Clinical and radiographic evaluations were conducted on days 0 (preoperative), 15 and 30 (postoperative). Clinical evaluation included lameness scoring, while radiographic assessment focused on fracture healing according to the Hammer scale, fracture reduction, intramedullary pin positioning, and callus formation. A significant reduction in lameness scores was observed on the 15th and 30th days in both groups. Although no statistically significant differences were detected between the groups on days 15, and 30, the PRP Group demonstrated lower scores. Based on the evaluations performed using the Hammer scale, no statistically significant differences were observed between the groups in callus formation and fracture line scores at the postoperative time points of days 15 and 30. However, upon examining the union score, the difference observed between the two time periods was found to be statistically significant, with a more pronounced effect in the PRP group on day 15. In conclusion, no complications were observed during the study. While PRP did not significantly alter the overall clinical healing process of long bone diaphyseal fractures in cats, it was found to accelerate early healing and reduce lameness.

Keywords

Callus, feline, growth factor, intramedullary pinning, platelets

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