KRONİK ÜRTİKERDE İKİNCİ KUŞAK ANTİHİSTAMİNLERİN YÜKSEK DOZ KULLANIMI

Year 2018, Volume: 3 Issue: 3, 80 - 91, 28.03.2018

Cemal Bilaç Zülküf Arslan

Abstract

Ürtiker tüm toplumlarda sık
görülen, aniden ortaya çıkıp aynı gün içinde kendiliğinden kaybolan kaşıntılı
ve ödemli plaklar ve/veya anjioödem ile karakterize bir deri hastalığıdır. Klinik
olarak altı haftadan kısa süren durumlar için “akut ürtiker” (AÜ), altı hafta
ya da daha uzun süren klinik durumlar için ise kronik ürtiker (KÜ) tanımı
kullanılır. H1 reseptör blokerleri tedavinin başlıca ilaçlarını
oluşturmaktadır. Güncel rehberler, tedaviye standart dozda antihistamin ilaç
ile başlanmasını önermektedir. Bununla birlikte yetersiz yanıt olması
durumunda, standart dozun dört katına kadar bir doz artışı önermektedirler. Bu makalede,
kronik ürtikerde ikinci kuşak antihistaminlerin yüksek dozda kullanımının etkinliği
ve yan etkileri ile ilgili literatürde yer alan bilgiler derlenmiştir.

Keywords

Ürtiker; Histamin H1 antagonistleri

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