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Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri

Year 2018, Volume: 1 Issue: 1, 1 - 7, 15.05.2018

Abstract

Amaç: İlerleyen yaş ile birlikte kişilerde görülen
komorbidite sayısı artmaktadır. Morbidite ve mortalite
artışına yol açan komorbiditeleri öngörebilmek ve
önleyebilmek için sebeplerini saptamak önemlidir. Son
yıllarda çok sayıda kronik hastalık ile ilişkisi araştırılan
parametrelerden biri de ürik asittir. Bu çalışmanın
amacı, ileri yaşta sık görülen kronik hastalıklar ile
serum ürik asit düzeyleri arasındaki ilişkileri
değerlendirmektir.
Metod: Geriatri kliniğine ayaktan başvuran ve ayrıntılı
geriatrik değerlendirme yapılan 971 hasta çalışmaya
dahil edildi. Tüm hastalar komorbiditeler açısından
sorgulandı. Serum ürik asit düzeyi erkeklerde ≥ 7,0
mg/dL ve kadınlarda ≥ 5,7 mg/dL hiperürisemi olarak
kabul edildi.
Bulgular: 971 hastadan 609’unun (%62,6) ürik asit
düzeyi normal, 364’ünün (%37,4) ürik asit düzeyi
yüksek saptandı. Ürik asit düzeyi ile cinsiyet, eğitim
seviyesi, medeni durum, noktüri, ağrı, diüretik
kullanımı ve kullanılan ilaç sayısı arasında anlamlı ilişki
saptandı (p<0,05). Ürik asit ile unutkanlık, üriner
inkontinans, düşme, denge bozukluğu, uyku
bozuklukları arasında anlamlı ilişki saptanmadı
(p>0,05). Charlson komorbidite indeksi ürik asit düzeyi
yüksek bireylerde artmış idi (p<0,05). Hastalar
komorbid hastalıklar açısından sorgulandığında,
hipertansiyon, kalp yetmezliği, diyabet, kronik
obstruktif akciğer hastalığı görülme sıklığı
hiperürisemili bireylerde artmış iken (p<0,001),
demans ürik asit düzeyi ile ters ilişkili idi (p<0,05).
Koroner arter hastalığı, periferik arter hastalığı,
serebrovasküler hastalık, tiroid hastalığı, osteoporoz,
depresyon ve hiperlipidemi sıklığı ise her iki grupta da
benzerdi (p>0,05).
Sonuç: Bu bulgular, serum ürik asit düzeyinin geriatrik
olgularda hipertansiyon, kalp yetmezliği, diyabet,
demans, kronik obstruktif akciğer hastalığı ve Charlson
komorbidite indeksi ile ilişkili olduğunu
göstermektedir. Ancak, bu ilişkilerin net olarak
aydınlatılabilmesi için, longitudinal çalışmalara ihtiyaç
duyulmaktadır.

References

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  • 2. Tinetti, M.E., et al., Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. Jama, 1995. 273(17): p. 1348-53.
  • 3. Inouye, S.K., et al., Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc, 2007. 55(5): p. 780-91.
  • 4. Fried, L.P., et al., Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001. 56(3): p. M146-56.
  • 5. Soysal, P., et al., Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev, 2016. 31: p. 1-8.
  • 6. Cruz-Jentoft, A.J., et al., Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010. 39(4): p. 412-23.
  • 7. Bulut, E.A., et al., Vitamin B12 deficiency might be related to sarcopenia in older adults. Exp Gerontol, 2017. 95: p. 136-140.
  • 8. Cesari, M., et al., Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci, 2014. 6: p. 192.
  • 9. Cruz-Jentoft, A.J., et al., Nutrition, frailty, and sarcopenia. Aging Clin Exp Res, 2017. 29(1): p. 43-48.
  • 10. Swift, C.G., The role of medical assessment and intervention in the prevention of falls. Age Ageing, 2006. 35 Suppl 2: p. ii65-ii68.
  • 11. Vaughan, C.P., et al., Urinary incontinence in older adults. Mt Sinai J Med, 2011. 78(4): p. 558-70.
  • 12. Ayello, E.A. and C.H. Lyder, Protecting patients from harm: preventing pressure ulcers in hospital patients. Nursing, 2007. 37(10): p. 36-40; quiz 40-1.
  • 13. Tekin, L., L. Ozcakar, and A.T. Isik, Delirium: a critical diagnosis for every member of the rehabilitation team. Rehabil Nurs, 2011. 36(5): p. 214-5.
  • 14. Inouye, S.K., Delirium in older persons. N Engl J Med, 2006. 354(11): p. 1157-65.
  • 15. Parazzini, F., et al., [Urinary incontinence: frequency and diagnostic and therapeutic approach in general practice in Italy]. Arch Ital Urol Androl, 2001. 73(3): p. 160-7.
  • 16. Janssen, I., et al., Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985), 2000. 89(2): p. 465-71.
  • 17. Chien, M.Y., T.Y. Huang, and Y.T. Wu, Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. J Am Geriatr Soc, 2008. 56(9): p. 1710-5.
  • 18. Cesari, M., et al., Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr, 2006. 83(5): p. 1142-8.
  • 19. Selekler K., C.B., Uluc S., Power Of Discrimination Of Montreal Cognitive Assessment (MOCA) Scale In Turkish Patients With Mild Cognitive Impairment And Alzheimer's Disease. Turkish Journal of Geriatrics. 2010; 13 (3) 166-171.
  • 20. Gungen, C., et al., [Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg, 2002. 13(4): p. 273-81.
  • 21. Babacan-Yildiz, G., et al., COST: Cognitive State Test, a brief screening battery for Alzheimer disease in illiterate and literate patients. Int Psychogeriatr, 2013. 25(3): p. 403-12.
  • 22. Lawton, M.P. and E.M. Brody, Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 1969. 9(3): p. 179-86.
  • 23.Tinetti, M.E., Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc, 1986. 34(2): p. 119-26.
  • 24. Guigoz, Y., The Mini Nutritional Assessment (MNA) review of the literature--What does it tell us? J Nutr Health Aging, 2006. 10(6): p. 466-85; discussion 485-7.
  • 25. Durmaz, B., et al., Validity and Reliability of Geriatric Depression Scale - 15 (Short Form) in Turkish older adults. Northern Clinics of Istanbul, 2018. 4(3): p. (inpress). doi: 10.14744/nci.2017.85047
  • 26. Collard, R.M., et al., Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc, 2012. 60(8): p. 1487-92.
  • 27. Eyigor, S., et al., Frailty prevalence and related factors in the older adult-FrailTURK Project. Age (Dordr), 2015. 37(3): p. 9791.
  • 28. Bennett, A., et al., Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs Aging, 2014. 31(3): p. 225-32.
  • 29. Safran, D.G., et al., Prescription drug coverage and seniors: findings from a 2003 national survey. Health Aff (Millwood), 2005. Suppl Web Exclusives: p. W5-152-w5-166.
  • 30. Plassman, B.L., et al., Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology, 2007. 29(1-2): p. 125-32.
  • 31. Roberts, R.O., et al., Urinary incontinence in a community-based cohort: prevalence and healthcare-seeking. J Am Geriatr Soc, 1998. 46(4): p. 467-72.
  • 32. Munch, T., et al., Pain and falls and fractures in community-dwelling older men. Age Ageing, 2015. 44(6): p. 973-9.
  • 33. Naseer, M., H. Forssell, and C. Fagerstrom, Malnutrition, functional ability and mortality among older people aged 60 years: a 7-year longitudinal study. Eur J Clin Nutr, 2016. 70(3): p. 399-404.
  • 34. Blazer, D.G., Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci, 2003. 58(3): p. 249-65.
  • 35. Djernes, J.K., Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand, 2006. 113(5): p. 372-87.
  • 36. Bolt, K. and A. Bergman, Systems biology of aging. Adv Exp M
Year 2018, Volume: 1 Issue: 1, 1 - 7, 15.05.2018

Abstract

References

  • 1. Durham. RH, eds. Encyclopedia of Medical Syndromes. New York: Harper and Brothers, 1960
  • 2. Tinetti, M.E., et al., Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. Jama, 1995. 273(17): p. 1348-53.
  • 3. Inouye, S.K., et al., Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc, 2007. 55(5): p. 780-91.
  • 4. Fried, L.P., et al., Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001. 56(3): p. M146-56.
  • 5. Soysal, P., et al., Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev, 2016. 31: p. 1-8.
  • 6. Cruz-Jentoft, A.J., et al., Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010. 39(4): p. 412-23.
  • 7. Bulut, E.A., et al., Vitamin B12 deficiency might be related to sarcopenia in older adults. Exp Gerontol, 2017. 95: p. 136-140.
  • 8. Cesari, M., et al., Sarcopenia and physical frailty: two sides of the same coin. Front Aging Neurosci, 2014. 6: p. 192.
  • 9. Cruz-Jentoft, A.J., et al., Nutrition, frailty, and sarcopenia. Aging Clin Exp Res, 2017. 29(1): p. 43-48.
  • 10. Swift, C.G., The role of medical assessment and intervention in the prevention of falls. Age Ageing, 2006. 35 Suppl 2: p. ii65-ii68.
  • 11. Vaughan, C.P., et al., Urinary incontinence in older adults. Mt Sinai J Med, 2011. 78(4): p. 558-70.
  • 12. Ayello, E.A. and C.H. Lyder, Protecting patients from harm: preventing pressure ulcers in hospital patients. Nursing, 2007. 37(10): p. 36-40; quiz 40-1.
  • 13. Tekin, L., L. Ozcakar, and A.T. Isik, Delirium: a critical diagnosis for every member of the rehabilitation team. Rehabil Nurs, 2011. 36(5): p. 214-5.
  • 14. Inouye, S.K., Delirium in older persons. N Engl J Med, 2006. 354(11): p. 1157-65.
  • 15. Parazzini, F., et al., [Urinary incontinence: frequency and diagnostic and therapeutic approach in general practice in Italy]. Arch Ital Urol Androl, 2001. 73(3): p. 160-7.
  • 16. Janssen, I., et al., Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol (1985), 2000. 89(2): p. 465-71.
  • 17. Chien, M.Y., T.Y. Huang, and Y.T. Wu, Prevalence of sarcopenia estimated using a bioelectrical impedance analysis prediction equation in community-dwelling elderly people in Taiwan. J Am Geriatr Soc, 2008. 56(9): p. 1710-5.
  • 18. Cesari, M., et al., Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. Am J Clin Nutr, 2006. 83(5): p. 1142-8.
  • 19. Selekler K., C.B., Uluc S., Power Of Discrimination Of Montreal Cognitive Assessment (MOCA) Scale In Turkish Patients With Mild Cognitive Impairment And Alzheimer's Disease. Turkish Journal of Geriatrics. 2010; 13 (3) 166-171.
  • 20. Gungen, C., et al., [Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg, 2002. 13(4): p. 273-81.
  • 21. Babacan-Yildiz, G., et al., COST: Cognitive State Test, a brief screening battery for Alzheimer disease in illiterate and literate patients. Int Psychogeriatr, 2013. 25(3): p. 403-12.
  • 22. Lawton, M.P. and E.M. Brody, Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist, 1969. 9(3): p. 179-86.
  • 23.Tinetti, M.E., Performance-oriented assessment of mobility problems in elderly patients. J Am Geriatr Soc, 1986. 34(2): p. 119-26.
  • 24. Guigoz, Y., The Mini Nutritional Assessment (MNA) review of the literature--What does it tell us? J Nutr Health Aging, 2006. 10(6): p. 466-85; discussion 485-7.
  • 25. Durmaz, B., et al., Validity and Reliability of Geriatric Depression Scale - 15 (Short Form) in Turkish older adults. Northern Clinics of Istanbul, 2018. 4(3): p. (inpress). doi: 10.14744/nci.2017.85047
  • 26. Collard, R.M., et al., Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc, 2012. 60(8): p. 1487-92.
  • 27. Eyigor, S., et al., Frailty prevalence and related factors in the older adult-FrailTURK Project. Age (Dordr), 2015. 37(3): p. 9791.
  • 28. Bennett, A., et al., Prevalence and impact of fall-risk-increasing drugs, polypharmacy, and drug-drug interactions in robust versus frail hospitalised falls patients: a prospective cohort study. Drugs Aging, 2014. 31(3): p. 225-32.
  • 29. Safran, D.G., et al., Prescription drug coverage and seniors: findings from a 2003 national survey. Health Aff (Millwood), 2005. Suppl Web Exclusives: p. W5-152-w5-166.
  • 30. Plassman, B.L., et al., Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology, 2007. 29(1-2): p. 125-32.
  • 31. Roberts, R.O., et al., Urinary incontinence in a community-based cohort: prevalence and healthcare-seeking. J Am Geriatr Soc, 1998. 46(4): p. 467-72.
  • 32. Munch, T., et al., Pain and falls and fractures in community-dwelling older men. Age Ageing, 2015. 44(6): p. 973-9.
  • 33. Naseer, M., H. Forssell, and C. Fagerstrom, Malnutrition, functional ability and mortality among older people aged 60 years: a 7-year longitudinal study. Eur J Clin Nutr, 2016. 70(3): p. 399-404.
  • 34. Blazer, D.G., Depression in late life: review and commentary. J Gerontol A Biol Sci Med Sci, 2003. 58(3): p. 249-65.
  • 35. Djernes, J.K., Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand, 2006. 113(5): p. 372-87.
  • 36. Bolt, K. and A. Bergman, Systems biology of aging. Adv Exp M
There are 36 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Özge Dokuzlar

Esra Ates Bulut

Süleyman Emre Koçyiğit

Publication Date May 15, 2018
Submission Date May 15, 2018
Published in Issue Year 2018 Volume: 1 Issue: 1

Cite

APA Dokuzlar, Ö., Ates Bulut, E., & Koçyiğit, S. E. (2018). Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri. Geriatrik Bilimler Dergisi, 1(1), 1-7.
AMA Dokuzlar Ö, Ates Bulut E, Koçyiğit SE. Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri. JoGS. May 2018;1(1):1-7.
Chicago Dokuzlar, Özge, Esra Ates Bulut, and Süleyman Emre Koçyiğit. “Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri”. Geriatrik Bilimler Dergisi 1, no. 1 (May 2018): 1-7.
EndNote Dokuzlar Ö, Ates Bulut E, Koçyiğit SE (May 1, 2018) Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri. Geriatrik Bilimler Dergisi 1 1 1–7.
IEEE Ö. Dokuzlar, E. Ates Bulut, and S. E. Koçyiğit, “Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri”, JoGS, vol. 1, no. 1, pp. 1–7, 2018.
ISNAD Dokuzlar, Özge et al. “Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri”. Geriatrik Bilimler Dergisi 1/1 (May 2018), 1-7.
JAMA Dokuzlar Ö, Ates Bulut E, Koçyiğit SE. Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri. JoGS. 2018;1:1–7.
MLA Dokuzlar, Özge et al. “Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri”. Geriatrik Bilimler Dergisi, vol. 1, no. 1, 2018, pp. 1-7.
Vancouver Dokuzlar Ö, Ates Bulut E, Koçyiğit SE. Geriatrik Olgularda Serum Ürik Asit Düzeylerinin Komorbid Hastalıklarla İlişkileri. JoGS. 2018;1(1):1-7.

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