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Year 2023, Volume: 3 Issue: 1, 13 - 25, 08.01.2023

Abstract

References

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  • Usul E, San I, Bekgoz B, Sahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark Med. 2020;14(13):1207-15. doi: 10.2217/bmm-2020-0317.
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  • Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84:106504 doi: 10.1016/j.intimp.2020.106504.
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  • Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. Oncotarget. 2017;8(34):57489-94. doi: 10.18632/oncotarget.15423.
  • Yu S, Arima H, Bertmar C, Clarke S, Herkes G, Krause M. Neutrophil to lymphocyte ratio and early clinical outcomes in patients with acute ischemic stroke. J Neurol Sci. 2018;387:115-8. doi: 10.1016/j.jns.2018.02.002.
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  • Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 2020;127:104362. doi: 10.1016/j.jcv.2020.104362.
  • Grillet F, Behr J, Calame P, Aubry S, Delabrousse E. Acute pulmonary embolism associated with COVID-19 pneumonia detected with pulmonary CT angiography. Radiology. 2020;296(3):E186-E188. doi: 10.1148/ radiol.2020201544.
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Significance of laboratory biomarkers in monitoring patients with COVID-19 pneumonia

Year 2023, Volume: 3 Issue: 1, 13 - 25, 08.01.2023

Abstract

Clinical and laboratory parameters are useful tools to improve success rates in the management of COVID-19 patients. Indices such as NLR, PLR, MHR, SII, AIP and CAR may indicate poor prognosis in predicting poor prognosis in COVID-19. It was aimed to identify such parameters of disease progression in COVID-19 patients by examining demographic data, comorbid conditions, some biochemical and hematological parameters. A retrospective analysis was performed for patients admitted to intensive care unit or pulmonary diseases department or treated on an outpatient basis due to a diagnosis of COVID-19. Patients with positive PCR test and thoracic CT compatible with COVID-19 pneumonia were included in the study. A control group was formed from volunteers of similar age and gender. The study population was divided into four groups as follows: patients admitted to intensive care unit (ICU group); patients admitted to chest diseases department (Inpatient Group); patients treated on an outpatient basis (Outpatient Group); and controls (Control Group). There were 61, 201, and 30 patients in the ICU, inpatient, and outpatient groups, respectively. A total of 96 subjects served as controls. Study groups were comparable with respect to gender distribution. ICU patients had higher NLR, PLR, AIP, SII, and CAR, and lower LMR as compared to other groups. NLR, SII, AIP, and CAR emerged as predictors of ICU admission, while MHR was predictive of inpatient treatment. Certain clinical and laboratory parameters may be useful tools for improving the success of COVID-19 management. High NLR, SII, AIP, CAR, and MHR values may indicate low prognosis in COVID-19 patients.

References

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  • Karatas MB, Canga Y, Ozcan KS, Ipek G, Gungor B, et al. Monocyte to high-density lipoprotein ratio as a new prognostic marker in patients with STEMI undergoing primary percutaneous coronary intervention. American J Emerg Med. 2016;34(2):240-4. doi: 10.1016/j.ajem.2015.10.049.
  • Dizman GT, Metan G, Ceylan CMA, Altunay H, Uzun M, et al. A COVID-19 First evaluation clinic at a university hospital in Turkey. Turkish J Med Sci. 2022;52:1-10. doi: 10.3906/sag-2104-152.
  • Sorokin AV, Karathanasis SK, Yang ZH, Freeman L, Kotani K, Remaley AT. COVID-19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches. FASEB J. 2020; 34(8):9843-53. doi: 10.1096/fj.202001451.
  • Li B, Li W, Li X, Zhou H. Inflammation: A novel therapeutic target/direction in atherosclerosis. Curr Pharm Design. 2017; 23 (8):1216-27. doi: 10.2 174/1381612822666161230142931.
  • Fois AG, Paliogiannis P, Scano V, Cau S, Babudieri S, et al. The systemic inflammation index on admission predicts in-hospital mortality in COVID-19 patients. Molecules. 2020;5(23):5725. doi: 10.3390/molecules25235725.
  • de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14(5):R192. doi: 10.1186/ cc9309.
  • Nalbant A, Kaya T, Varim C, Yaylaci S, Tamer A, et al. Can the neutrophil/lymphocyte ratio (NLR) have a role in the diagnosis of coronavirus 2019 disease (COVID-19)? Revis Assoc Méd Brasileira. 2020;66(6):746-51. doi: 10.1590/1806-9282.66.6.746.
  • Sun S, Cai X, Wang H, He G, Lin Y, et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clin Chim Acta. 2020; 507: 174-180. doi: 10.1016/j. cca.2020.04.024.
  • Ertem AG, Yayla C, Acar B, Kirbas O, Unal S, et al. Relation between lymphocyte to monocyte ratio and short-term mortality in patients with acute pulmonary embolism. Clin Resp J. 2018;12(2):580- 6. doi: 10.1111/crj.12565.
  • Yayla Ç, Akboğa MK, Yayla KG, Ertem AG, Efe TH, et al. A novel marker of inflammation in patients with slow coronary flow: lymphocyte-tomonocyte ratio. Biomark Med. 2016;10(5):485-93. doi: 10.2217/bmm-2016-0022.
  • Lattanzi S, Cagnetti C, Provinciali L, Silvestrini M. Neutrophil-to-lymphocyte ratio and neurological deterioration following acute cerebral hemorrhage. Oncotarget. 2017;8(34):57489-94. doi: 10.18632/oncotarget.15423.
  • Yu S, Arima H, Bertmar C, Clarke S, Herkes G, Krause M. Neutrophil to lymphocyte ratio and early clinical outcomes in patients with acute ischemic stroke. J Neurol Sci. 2018;387:115-8. doi: 10.1016/j.jns.2018.02.002.
  • Dotsenko O, Chaturvedi N, Thom SAM, Wright AR, Mayet J, et al. Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. J Throm Haemost. 2007;5(10):2036-42. doi: 10.1111/j.1538- 7836.2007.02711.x.
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  • Giannis D, Ziogas IA, Gianni P. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. J Clin Virol. 2020;127:104362. doi: 10.1016/j.jcv.2020.104362.
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There are 61 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Hasan Ölmez This is me 0000-0003-4153-9953

Mustafa Tosun This is me 0000-0002-5204-2099

Publication Date January 8, 2023
Published in Issue Year 2023 Volume: 3 Issue: 1

Cite

Vancouver Ölmez H, Tosun M. Significance of laboratory biomarkers in monitoring patients with COVID-19 pneumonia. Health Sci. Q. 2023;3(1):13-25.