Case Report
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TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS

Year 2023, Volume: 86 Issue: 4, 402 - 405, 01.12.2023
https://doi.org/10.26650/IUITFD.1281081

Abstract

Transient benign hyperphosphatasemia (TBH) is a benign condition characterized by transiently elevated serum alkaline phosphatase (ALP) levels by 3-50 times normal values. It can sometimes be seen in connection with different clinical disorders such as respiratory tract infections, gastrointestinal diseases, congenital metabolic disorders, malignancies, congenital anomalies, anemia, and neurological disorders. In this report, we describe three children who had TBH after rotavirus-associated gastroenteritis and in whom there was no evidence of liver or bone disease. We aim to raise awareness and draw attention to TBH in this case report.

Project Number

yok

References

  • 1. Lowe D, Sanvictores T, John S. Alkaline phosphatase. StatPearls Publishing: Treasure Island, FL, USA. 2022. google scholar
  • 2. Çiçek G, Özen EU. Karaciğer histolojisi ve embriyolojisi. In: Anılır E, Önal Z, İbrişim D, editors. Hepatoloji. Ankara: Akademisyen Kitabevi; 2020. p. 15-28. google scholar
  • 3. Çakır BÇ, Kırsaçlıoğlu CT, Tartıcı EK, Demirel F. Transient hyperphosphatasemia in infants and children: a retrospective study of 43 cases. J Contemp Med 2017;7(2):138-42. [CrossRef] google scholar
  • 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child 1985;139(7):736-40. [CrossRef] google scholar
  • 5. Dursun F, Kirmizibekmez H. A case series of benign transient hyperphosphatasemia from a pediatric endocrinology reference health facility in Turkey. Pan African Medical Journal. 2018;30(1). [CrossRef] google scholar
  • 6. Banerjee S, Mehta R, Thu M, Narwal S, Moukarzel AA. Rotavirus infection and diarrhea resulting in transient hyperphosphatasemia with no evidence of liver or bone disease. J Pediatr Gastroenterol Nutr 1998;27(4):488. [CrossRef] google scholar
  • 7. Erat T, Atar M, Kontbay T. Transient benign hyperphosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab 2021;34(3):385-7. [CrossRef] google scholar
  • 8. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013;57(2):167-71. [CrossRef] google scholar
  • 9. Behülovâ D, Bzduch V, Holesovâ D, Vasilenkovâ A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000;46(11):1868-9. [CrossRef] google scholar
  • 10. Shkalim Zemer V, Hoshen M, Levinsky Y, Richenberg Y, Yosef N, Oberman B, et al. Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr 2023: 182(7):3211-6. [CrossRef] google scholar
  • 11. Suzuki M, Okazaki T, Nagai T, Törö K, Setonyi P Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002;33(3):215-8. [CrossRef] google scholar
  • 12. Chu AS, Rothschild JG. Update on benign transient hyperphosphatasemia: recognizing an underappreciated condition. Clin Pediatr. 2016;55(6):564-6. [CrossRef] google scholar
  • 13. Huh SY, Feldman HA, Cox JE, Gordon CM. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009;124(2):703-9. [CrossRef] google scholar
  • 14. Gallo S, Comeau K, Sharma A, Vanstone CA, Agellon S, Mitchell J, et al. Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada. Clin Biochem 2014;47(15):27-32. [CrossRef] google scholar
  • 15. Schonhaut BL, Rocha RA. Benign transient hyperphosphatasaemia in infants: clinical series. Rev Chil Pediatr 2017;88(1):169-75. google scholar
  • 16. Ridefelt P, Gustafsson J, Aldrimer M, Hellberg D. Alkaline phosphatase in healthy children: reference intervals and prevalence of elevated levels. Horm Res Paediatr 2014;82(6):399-404. [CrossRef] google scholar
  • 17. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011;24(5-6):351-3. [CrossRef] google scholar

ROTAVİRÜS GASTROENTERİTİNE BAĞLI GEÇİCİ BENİGN HİPERFOSFATAZEMİ

Year 2023, Volume: 86 Issue: 4, 402 - 405, 01.12.2023
https://doi.org/10.26650/IUITFD.1281081

Abstract

Geçici benign hiperfosfatazemi (TBH), serum alkalen fosfataz (ALP) düzeylerinin normalin 3-50 katı kadar geçici olarak yükselmesi ile karakterize ve bazen de gastrointestinal hastalıklar, solunum yolu enfeksiyonları, doğumsal anomaliler, doğumsal metabolik bozukluklar, anemi, maligniteler, nörolojik bozukluklar gibi farklı klinik bozukluklarla birlikte görülebilmektedir. Bu çalışmada, karaciğer veya kemik hastalığı olmayan, rotavirüs ile ilişkili gastroenterit sonrası TBH'li üç çocuk sunuldu. Bu olguların sunulması ile TBH konusuna dikkat çekilmesi ve farkındalık yaratılması amaçlandı.

Supporting Institution

yok

Project Number

yok

References

  • 1. Lowe D, Sanvictores T, John S. Alkaline phosphatase. StatPearls Publishing: Treasure Island, FL, USA. 2022. google scholar
  • 2. Çiçek G, Özen EU. Karaciğer histolojisi ve embriyolojisi. In: Anılır E, Önal Z, İbrişim D, editors. Hepatoloji. Ankara: Akademisyen Kitabevi; 2020. p. 15-28. google scholar
  • 3. Çakır BÇ, Kırsaçlıoğlu CT, Tartıcı EK, Demirel F. Transient hyperphosphatasemia in infants and children: a retrospective study of 43 cases. J Contemp Med 2017;7(2):138-42. [CrossRef] google scholar
  • 4. Kraut JR, Metrick M, Maxwell NR, Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child 1985;139(7):736-40. [CrossRef] google scholar
  • 5. Dursun F, Kirmizibekmez H. A case series of benign transient hyperphosphatasemia from a pediatric endocrinology reference health facility in Turkey. Pan African Medical Journal. 2018;30(1). [CrossRef] google scholar
  • 6. Banerjee S, Mehta R, Thu M, Narwal S, Moukarzel AA. Rotavirus infection and diarrhea resulting in transient hyperphosphatasemia with no evidence of liver or bone disease. J Pediatr Gastroenterol Nutr 1998;27(4):488. [CrossRef] google scholar
  • 7. Erat T, Atar M, Kontbay T. Transient benign hyperphosphatasemia due to COVID-19: the first case report. J Pediatr Endocrinol Metab 2021;34(3):385-7. [CrossRef] google scholar
  • 8. Gualco G, Lava SA, Garzoni L, Simonetti GD, Bettinelli A, Milani GP, et al. Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr 2013;57(2):167-71. [CrossRef] google scholar
  • 9. Behülovâ D, Bzduch V, Holesovâ D, Vasilenkovâ A, Ponec J. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000;46(11):1868-9. [CrossRef] google scholar
  • 10. Shkalim Zemer V, Hoshen M, Levinsky Y, Richenberg Y, Yosef N, Oberman B, et al. Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr 2023: 182(7):3211-6. [CrossRef] google scholar
  • 11. Suzuki M, Okazaki T, Nagai T, Törö K, Setonyi P Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002;33(3):215-8. [CrossRef] google scholar
  • 12. Chu AS, Rothschild JG. Update on benign transient hyperphosphatasemia: recognizing an underappreciated condition. Clin Pediatr. 2016;55(6):564-6. [CrossRef] google scholar
  • 13. Huh SY, Feldman HA, Cox JE, Gordon CM. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009;124(2):703-9. [CrossRef] google scholar
  • 14. Gallo S, Comeau K, Sharma A, Vanstone CA, Agellon S, Mitchell J, et al. Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada. Clin Biochem 2014;47(15):27-32. [CrossRef] google scholar
  • 15. Schonhaut BL, Rocha RA. Benign transient hyperphosphatasaemia in infants: clinical series. Rev Chil Pediatr 2017;88(1):169-75. google scholar
  • 16. Ridefelt P, Gustafsson J, Aldrimer M, Hellberg D. Alkaline phosphatase in healthy children: reference intervals and prevalence of elevated levels. Horm Res Paediatr 2014;82(6):399-404. [CrossRef] google scholar
  • 17. Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011;24(5-6):351-3. [CrossRef] google scholar
There are 17 citations in total.

Details

Primary Language English
Subjects Health Services and Systems (Other)
Journal Section Case Reports
Authors

Yasin Akkuş 0000-0001-9782-7458

Muharrem Çiçek 0000-0002-8619-2722

Melek Elma 0000-0002-8687-4950

Selen Baran Özmen 0000-0001-6495-0273

Özlem Kalaycık Şengül 0000-0001-9594-5231

Project Number yok
Publication Date December 1, 2023
Submission Date April 20, 2023
Published in Issue Year 2023 Volume: 86 Issue: 4

Cite

APA Akkuş, Y., Çiçek, M., Elma, M., Baran Özmen, S., et al. (2023). TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS. Journal of Istanbul Faculty of Medicine, 86(4), 402-405. https://doi.org/10.26650/IUITFD.1281081
AMA Akkuş Y, Çiçek M, Elma M, Baran Özmen S, Kalaycık Şengül Ö. TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS. İst Tıp Fak Derg. December 2023;86(4):402-405. doi:10.26650/IUITFD.1281081
Chicago Akkuş, Yasin, Muharrem Çiçek, Melek Elma, Selen Baran Özmen, and Özlem Kalaycık Şengül. “TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS”. Journal of Istanbul Faculty of Medicine 86, no. 4 (December 2023): 402-5. https://doi.org/10.26650/IUITFD.1281081.
EndNote Akkuş Y, Çiçek M, Elma M, Baran Özmen S, Kalaycık Şengül Ö (December 1, 2023) TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS. Journal of Istanbul Faculty of Medicine 86 4 402–405.
IEEE Y. Akkuş, M. Çiçek, M. Elma, S. Baran Özmen, and Ö. Kalaycık Şengül, “TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS”, İst Tıp Fak Derg, vol. 86, no. 4, pp. 402–405, 2023, doi: 10.26650/IUITFD.1281081.
ISNAD Akkuş, Yasin et al. “TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS”. Journal of Istanbul Faculty of Medicine 86/4 (December 2023), 402-405. https://doi.org/10.26650/IUITFD.1281081.
JAMA Akkuş Y, Çiçek M, Elma M, Baran Özmen S, Kalaycık Şengül Ö. TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS. İst Tıp Fak Derg. 2023;86:402–405.
MLA Akkuş, Yasin et al. “TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS”. Journal of Istanbul Faculty of Medicine, vol. 86, no. 4, 2023, pp. 402-5, doi:10.26650/IUITFD.1281081.
Vancouver Akkuş Y, Çiçek M, Elma M, Baran Özmen S, Kalaycık Şengül Ö. TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS. İst Tıp Fak Derg. 2023;86(4):402-5.

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